World's Best Scientists 2026 revealed!
Paul M. P. van Bergen en Henegouwen

Paul M. P. van Bergen en Henegouwen

D-Index & Metrics

Biology and Biochemistry

D-Index
63
Citations
11769
World Ranking
10404
National Ranking
271

Overview

Paul M. P. van Bergen en Henegouwen is affiliated with Utrecht University in the Netherlands. Their research spans several fields within medicine and molecular biology, with prominent subfields of study including molecular biology, radiology, nuclear medicine and imaging, biomedical engineering, pulmonary and respiratory medicine, and oncology.

The primary topics of their work focus on monoclonal and polyclonal antibodies research, glycosylation and glycoproteins research, advanced biosensing techniques and applications, photodynamic therapy research studies, cell adhesion molecules research, HER2/EGFR in cancer research, and nanoplatforms for cancer theranostics.

Their recent papers include the following:

  • Nanobody-targeted photodynamic therapy induces significant tumor regression of trastuzumab-resistant HER2-positive breast cancer, after a single treatment session (2020, Journal of Controlled Release)
  • Homogeneous tumor targeting with a single dose of HER2-targeted albumin-binding domain-fused nanobody-drug conjugates results in long-lasting tumor remission in mice (2021, Theranostics)
  • Acute cellular and vascular responses to photodynamic therapy using EGFR-targeted nanobody-photosensitizer conjugates studied with intravital optical imaging and magnetic resonance imaging (2020, Theranostics)
  • Implications for tetraspanin-enriched microdomain assembly based on structures of CD9 with EWI-F (2020, Life Science Alliance)
  • Site-specific functionality and tryptophan mimicry of lipidation in tetraspanin CD9 (2020, FEBS Journal)

Frequent coauthors collaborating with Paul M. P. van Bergen en Henegouwen include:

  • Katerina T. Xenaki
  • Sabrina Oliveira
  • Sofia Doulkeridou
  • Vida Mashayekhi
  • Piet Gros

Their research has been regularly published in venues such as Theranostics, Journal of Controlled Release, bioRxiv (Cold Spring Harbor Laboratory), Scientific Reports, and Life Science Alliance.

These research outputs contribute primarily to the fields of medicine and biochemistry, genetics, and molecular biology, reflecting an interdisciplinary approach centered around cancer research, imaging technologies, and molecular targeting strategies.

Best Publications

  • Efficient inhibition of EGFR signaling and of tumour growth by antagonistic anti-EFGR Nanobodies.

    Rob C. Roovers;Toon Laeremans;Lieven Huang;Severine De Taeye

  • The epidermal growth factor.

    Johannes Boonstra;Philip Rijken;Bruno Humbel;Fons Cremers

  • Amphiregulin Enhances Regulatory T Cell-Suppressive Function via the Epidermal Growth Factor Receptor

    Dietmar M.W. Zaiss;Jorg van Loosdregt;Andrea Gorlani;Cornelis P.J. Bekker

  • A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K–Akt signalling

    Lara Fallon;Catherine M.L. Bélanger;Amadou T. Corera;Maria Kontogiannea

  • A biparatopic anti-EGFR nanobody efficiently inhibits solid tumour growth

    Rob C. Roovers;Maria J.W.D. Vosjan;Toon Laeremans;Rachid el Khoulati

  • Nanobody-based cancer therapy of solid tumors

    Marta Kijanka;Bram Dorresteijn;Sabrina Oliveira;Paul M P van Bergen en Henegouwen

  • ErbB1 dimerization is promoted by domain co-confinement and stabilized by ligand binding

    Shalini T Low-Nam;Keith A Lidke;Patrick J Cutler;Rob C Roovers

  • The blood-brain barrier transmigrating single domain antibody: mechanisms of transport and antigenic epitopes in human brain endothelial cells.

    Abedelnasser Abulrob;Hein Sprong;Paul Van Bergen en Henegouwen;Danica Stanimirovic

  • Targeting tumors with nanobodies for cancer imaging and therapy

    Sabrina Oliveira;Raimond Heukers;Jirawas Sornkom;Robbert J Kok

  • Antibody or Antibody Fragments : Implications for Molecular Imaging and Targeted Therapy of Solid Tumors

    Katerina T. Xenaki;Sabrina Oliveira;Paul M. P. van Bergen en Henegouwen

  • Structural Evaluation of EGFR Inhibition Mechanisms for Nanobodies/VHH Domains.

    Karl R. Schmitz;Atrish Bagchi;Rob C. Roovers;Paul M.P. van Bergen en Henegouwen

  • Rapid visualization of human tumor xenografts through optical imaging with a near-infrared fluorescent anti-epidermal growth factor receptor nanobody.

    Sabrina Oliveira;Guus A.M.S. van Dongen;Marijke Stigter-van Walsum;Rob C. Roovers

  • Resolving bundled microtubules using anti-tubulin nanobodies

    Marina Mikhaylova;Bas M C Cloin;Kieran Finan;Robert van den Berg

  • Homo-FRET Imaging Enables Quantification of Protein Cluster Sizes with Subcellular Resolution

    Arjen N. Bader;Erik G. Hofman;Jarno Voortman;Paul M.P. van Bergen en Henegouwen

  • Protein Kinase Cζ Is a Negative Regulator of Protein Kinase B Activity

    Robert P. Doornbos;Marga Theelen;Paul C.J. van der Hoeven;Wim J. van Blitterswijk

  • Association and Colocalization of Eps15 with Adaptor Protein-2 and Clathrin

    Sanne van Delft;Christopher Schumacher;Willem Hage;Arie J. Verkleij

  • Integrated fluorescence and transmission electron microscopy.

    Alexandra V. Agronskaia;Jack A. Valentijn;Linda F. van Driel;Chris T.W.M. Schneijdenberg

  • EGFR Dynamics Change during Activation in Native Membranes as Revealed by NMR

    Mohammed Kaplan;Siddarth Narasimhan;Cecilia de Heus;Deni Mance

  • Downregulation of EGFR by a novel multivalent nanobody-liposome platform

    Sabrina Oliveira;Raymond M. Schiffelers;Joris van der Veeken;Roy van der Meel

  • EGF induces coalescence of different lipid rafts

    Erik G. Hofman;Mika O. Ruonala;Arjen N. Bader;Dave van den Heuvel

Frequent Co-Authors

Arie J. Verkleij
Arie J. Verkleij Utrecht University
Johannes Boonstra
Johannes Boonstra Utrecht University
Paul J. van Diest
Paul J. van Diest Utrecht University
Casper C. Hoogenraad
Casper C. Hoogenraad Utrecht University
Henk M.W. Verheul
Henk M.W. Verheul Radboud University
Tanja D. de Gruijl
Tanja D. de Gruijl Vrije Universiteit Amsterdam
Willem P.Th.M. Mali
Willem P.Th.M. Mali Utrecht University
Raymond M. Schiffelers
Raymond M. Schiffelers Utrecht University
Lukas C. Kapitein
Lukas C. Kapitein Utrecht University
Wim E. Hennink
Wim E. Hennink Utrecht University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Expanding your studies in Biology and Biochemistry opens doors to many dynamic career paths. Many students look to specialized online degrees and certificate programs to enhance their qualifications, flexibility, and career options.

For those interested in movement science, an online kinesiology degree can lead to roles in sports, fitness, and rehabilitation. Healthcare professionals may pursue advanced practice certificates, such as pmhnp online programs to focus on psychiatric and mental health care.

If you're looking for accelerated qualification, a 12-month fnp program online enables you to quickly become a Family Nurse Practitioner, applying your science background to primary care. Alternatively, those passionate about nutrition can explore a dietician degree online to work in wellness, clinical health, or food science.

Online degrees provide flexibility and diversity in career advancement. Consider your interests and future goals to choose the best pathway in life sciences or healthcare.

Best Scientists Citing Paul M. P. van Bergen en Henegouwen

Trending Scientists

Recently Published Articles