World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
57
Citations
13765
World Ranking
13681
National Ranking
5799

Overview

Diane E. Handy is affiliated with Brigham and Women's Hospital in the United States. Their research spans multiple areas within biochemistry, genetics, molecular biology, and medicine, focusing significantly on the molecular mechanisms underlying health and disease.

Their recent publications include the following:

  • The role of glutathione peroxidase-1 in health and disease, 2022, Free Radical Biology and Medicine
  • Selenium, a Micronutrient That Modulates Cardiovascular Health via Redox Enzymology, 2021, Nutrients
  • Comprehensive network medicine-based drug repositioning via integration of therapeutic efficacy and side effects, 2022, npj Systems Biology and Applications
  • A Type 2 Deiodinase-Dependent Increase in Vegfa Mediates Myoblast-Endothelial Cell Crosstalk During Skeletal Muscle Regeneration, 2020, Thyroid
  • Integration of circulating microRNAs and transcriptome signatures identifies early-pregnancy biomarkers of preeclampsia, 2023, Clinical and Translational Medicine

The scientist's frequent co-authors include:

  • Joseph Loscalzo
  • Rui-Sheng Wang
  • Jacob Joseph
  • Farzaneh Firoozbakht
  • Maria L. Elkjaer

Research is published across various venues, notably:

  • Free Radical Biology and Medicine
  • Nutrients
  • npj Systems Biology and Applications
  • Thyroid
  • Clinical and Translational Medicine

Their work covers multiple fields and subfields, including:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine
  • Molecular Biology
  • Pharmacology
  • Computational Theory and Mathematics
  • Cancer Research
  • Nutrition and Dietetics

Main topics of research addressed by Diane E. Handy are:

  • Computational Drug Discovery Methods
  • Selenium in Biological Systems
  • Bioinformatics and Genomic Networks
  • Cancer, Hypoxia, and Metabolism
  • Pharmacogenetics and Drug Metabolism
  • Organoselenium and organotellurium chemistry
  • Redox biology and oxidative stress

Best Publications

  • Glutathione Peroxidase-1 in Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities

    Edith Lubos;Joseph Loscalzo;Diane E. Handy

  • Epigenetic Modifications Basic Mechanisms and Role in Cardiovascular Disease

    Diane E. Handy;Rita Castro;Joseph Loscalzo

  • NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism

    Wusheng Xiao;Rui-Sheng Wang;Diane E. Handy;Joseph Loscalzo

  • Redox regulation of mitochondrial function.

    Diane E. Handy;Joseph Loscalzo

  • Network-based approach to prediction and population-based validation of in silico drug repurposing

    Feixiong Cheng;Feixiong Cheng;Rishi J. Desai;Diane E. Handy;Ruisheng Wang

  • Role of oxidative stress and nitric oxide in atherothrombosis.

    Edith Lubos;Diane E Handy;Joseph Loscalzo

  • High glucose inhibits glucose-6-phosphate dehydrogenase, leading to increased oxidative stress and β-cell apoptosis

    Zhaoyun Zhang;Chong Wee Liew;Diane E. Handy;Yingyi Zhang

  • Glucose-6-Phosphate Dehydrogenase Modulates Cytosolic Redox Status and Contractile Phenotype in Adult Cardiomyocytes

    Mohit Jain;Daniel A. Brenner;Lei Cui;Chee Chew Lim

  • Selenoprotein Gene Nomenclature

    Vadim N. Gladyshev;Vadim N. Gladyshev;Elias S. Arnér;Marla J. Berry;Regina Brigelius-Flohé

  • Aldosterone inactivates the endothelin-B receptor via a cysteinyl thiol redox switch to decrease pulmonary endothelial nitric oxide levels and modulate pulmonary arterial hypertension.

    Bradley A. Maron;Ying-Yi Zhang;Kevin White;Stephen Y. Chan

  • Elevated Levels of Homocysteine Compromise Blood-Brain Barrier Integrity in Mice.

    Atul F. Kamath;Anil K. Chauhan;Anil K. Chauhan;Anil K. Chauhan;Janka Kisucka;Janka Kisucka;Janka Kisucka;Vandana S. Dole;Vandana S. Dole;Vandana S. Dole

  • Early pregnancy vitamin D status and risk of preeclampsia

    Hooman Mirzakhani;Augusto A. Litonjua;Thomas F. McElrath;George O’Connor

  • Impaired Angiogenesis in Glutathione Peroxidase-1–Deficient Mice Is Associated With Endothelial Progenitor Cell Dysfunction

    Gennaro Galasso;Stephan Schiekofer;Kaori Sato;Rei Shibata

  • Determinants of Human Plasma Glutathione Peroxidase (GPx-3) Expression

    Charlene Bierl;Barbara Voetsch;Richard C. Jin;Diane E. Handy

  • Glutathione peroxidase-1 regulates mitochondrial function to modulate redox-dependent cellular responses.

    Diane E. Handy;Edith Lubos;Yi Yang;John D. Galbraith

  • Both maximal expression of selenoproteins and selenoprotein deficiency can promote development of type 2 diabetes-like phenotype in mice.

    Vyacheslav M. Labunskyy;Byung Cheon Lee;Diane E. Handy;Joseph Loscalzo

  • Role of the α2B-Adrenergic Receptor in the Development of Salt-Induced Hypertension

    Konstantinos P. Makaritsis;Diane E. Handy;Conrado Johns;Brian Kobilka

  • Epigenetic modifications: basic mechanisms and role in cardiovascular disease (2013 Grover Conference series)

    Joseph Loscalzo;Diane E. Handy

  • The Short N-terminal Domains of STIM1 and STIM2 Control the Activation Kinetics of Orai1 Channels

    Yandong Zhou;Salvatore Mancarella;Youjun Wang;Chanyu Yue

  • Erratum: Mechanism of inhibition of Rho-dependent transcription termination by bacteriophage P4 protein Psu (Journal of Biological Chemistry (2006) vol. 281 (26491-26500))

    Bibhusita Pani;Sharmistha Banerjee;Jisha Chalissery;Abishek Muralimohan

Frequent Co-Authors

Joseph Loscalzo
Joseph Loscalzo Harvard Medical School
Haralambos Gavras
Haralambos Gavras Boston University
Ronglih Liao
Ronglih Liao Stanford University
Vadim N. Gladyshev
Vadim N. Gladyshev Brigham and Women's Hospital
Dolph L. Hatfield
Dolph L. Hatfield National Institutes of Health
John E. Coligan
John E. Coligan National Institutes of Health
Bradley A. Carlson
Bradley A. Carlson National Institutes of Health
Clinton T. Baldwin
Clinton T. Baldwin Boston University
Lindsay A. Farrer
Lindsay A. Farrer Boston University
Daniel S. Kohane
Daniel S. Kohane Harvard Medical School

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Studying Biology and Biochemistry opens the door to a wide range of specialized and interdisciplinary career options. For those interested in leadership and management in healthcare settings, online healthcare mba programs offer a flexible way to gain business acumen while deepening your expertise in the life sciences field.

Another growing field is medical billing and coding, crucial for keeping healthcare systems running smoothly. If you’re considering this path, it’s important to compare certification options. Learn about the ccs vs cpc certification to decide which aligns best with your goals.

Earning potential is another key factor. Find out how much do medical coders make based on experience, location, and certification level.

Finally, when mapping out your future, be sure to weigh the job outlook for medical billing and coding, including work environments, salary trends, and potential for professional growth.

Best Scientists Citing Diane E. Handy

Trending Scientists

Recently Published Articles