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Biology and Biochemistry

D-Index
81
Citations
28652
World Ranking
3825
National Ranking
13

Overview

Miguel P. Soares is affiliated with the Instituto Gulbenkian de Ciência in Portugal. Their research spans several intersecting areas in biomedical sciences, focusing on molecular biology, immunology, and public health.

The scientist's main fields of study include Medicine and Biochemistry, Genetics, and Molecular Biology. Subfields of emphasis cover Molecular Biology, Immunology, Public Health, Environmental and Occupational Health, Genetics, and Epidemiology.

The research topics addressed in Soares's work highlight several key areas:

  • Heme Oxygenase-1 and Carbon Monoxide
  • Immune cells in cancer
  • Mosquito-borne diseases and control
  • Hemoglobinopathies and Related Disorders
  • Malaria Research and Control
  • Immune responses and vaccinations
  • Sepsis Diagnosis and Treatment

Soares has published frequently in venues such as bioRxiv (Cold Spring Harbor Laboratory), FEBS Journal, SSRN Electronic Journal, The EMBO Journal, and Cell Reports. These outlets reflect a mix of preprint repositories and peer-reviewed journals in molecular biology and immunology.

Among the recent papers authored or co-authored by Soares are the following:

  • "M. tuberculosis Reprograms Hematopoietic Stem Cells to Limit Myelopoiesis and Impair Trained Immunity," 2020, Cell
  • "Heme catabolism by tumor-associated macrophages controls metastasis formation," 2021, Nature Immunology
  • "Trained innate immunity, long-lasting epigenetic modulation, and skewed myelopoiesis by heme," 2021, Proceedings of the National Academy of Sciences
  • "Heme oxygenase-1 orchestrates the immunosuppressive program of tumor-associated macrophages," 2020, JCI Insight
  • "Reframing sepsis immunobiology for translation: towards informative subtyping and targeted immunomodulatory therapies," 2024, The Lancet Respiratory Medicine

Collaboration is an important aspect of Soares's career, with frequent co-authors including Sílvia Cardoso, Sebastian Weis, Elisa Jentho, Rui Martins, and Susana Ramos. These collaborations span a range of projects likely contributing to the scientist's multidisciplinary research output.

Best Publications

  • Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway

    Leo E. Otterbein;Leo E. Otterbein;Fritz H. Bach;Jawed Alam;Miguel P. Soares

  • Disease Tolerance as a Defense Strategy

    Ruslan Medzhitov;David S. Schneider;Miguel P. Soares

  • Heme oxygenase-1: unleashing the protective properties of heme

    Leo E. Otterbein;Miguel P. Soares;Kenichiro Yamashita;Fritz H. Bach

  • Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis.

    Sophie Brouard;Leo E. Otterbein;Josef Anrather;Edda Tobiasch

  • Mechanisms of Cell Protection by Heme Oxygenase-1

    Raffaella Gozzelino;Viktoria Jeney;Miguel P. Soares

  • Expression of heme oxygenase-1 can determine cardiac xenograft survival

    M. P. Soares;Y. Lin;J. Anrather;E. Csizmadia

  • Different faces of the heme-heme oxygenase system in inflammation

    Frank A. D. T. G. Wagener;Hans-Dieter Volk;Dean Willis;Nader G. Abraham

  • Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria

    Ana Pamplona;Ana Pamplona;Ana Ferreira;József Balla;Viktória Jeney

  • Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury

    Leo E Otterbein;Brian S Zuckerbraun;Manabu Haga;Fang Liu

  • Carbon Monoxide Generated by Heme Oxygenase-1 Suppresses the Rejection of Mouse-to-Rat Cardiac Transplants

    K. Sato;J. Balla;L. Otterbein;R. N. Smith

  • Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis

    Monika Bambouskova;Laurent Gorvel;Vicky Lampropoulou;Alexey Sergushichev

  • Heme Oxygenase-1 Modulates the Expression of Adhesion Molecules Associated with Endothelial Cell Activation

    Miguel P. Soares;Mark P. Seldon;Isabel Pombo Gregoire;Tatiana Vassilevskaia

  • A central role for free heme in the pathogenesis of severe sepsis.

    Rasmus Larsen;Raffaella Gozzelino;Viktória Jeney;László Tokaji

  • Heme Oxygenase-1-derived Carbon Monoxide Requires the Activation of Transcription Factor NF-κB to Protect Endothelial Cells from Tumor Necrosis Factor-α-mediated Apoptosis

    Sophie Brouard;Pascal O. Berberat;Edda Tobiasch;Mark P. Seldon

  • Gut Microbiota Elicits a Protective Immune Response against Malaria Transmission

    Bahtiyar Yilmaz;Silvia Portugal;Tuan M. Tran;Raffaella Gozzelino

  • Sickle hemoglobin confers tolerance to Plasmodium infection.

    Ana Ferreira;Ivo Marguti;Ingo Bechmann;Ingo Bechmann;Viktória Jeney

  • Heme oxygenase–1 and carbon monoxide suppress autoimmune neuroinflammation

    Ângelo A. Chora;Paulo Fontoura;Andreia Cunha;Teresa F. Pais

  • Macrophages and Iron Metabolism

    Miguel P. Soares;Iqbal Hamza

  • Heme oxygenase-1 affords protection against noncerebral forms of severe malaria

    Elsa Seixas;Raffaella Gozzelino;Ângelo Chora;Ana Ferreira

  • Bilirubin: a natural inhibitor of vascular smooth muscle cell proliferation.

    Robert Ollinger;Martin Bilban;Anna Erat;Alberto Froio

Frequent Co-Authors

Fritz H. Bach
Fritz H. Bach Harvard Medical School
Leo E. Otterbein
Leo E. Otterbein Beth Israel Deaconess Medical Center
Josef Anrather
Josef Anrather Cornell University
Hervé Bazin
Hervé Bazin Université Catholique de Louvain
Simon C. Robson
Simon C. Robson Beth Israel Deaconess Medical Center
Augustine M. K. Choi
Augustine M. K. Choi Cornell University
Anny Usheva
Anny Usheva Brown University
Wayne W. Hancock
Wayne W. Hancock University of Pennsylvania
Anupam Agarwal
Anupam Agarwal University of Alabama at Birmingham
Gabriel Núñez
Gabriel Núñez University of Michigan–Ann Arbor

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