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Chemistry

D-Index
59
Citations
12786
World Ranking
10113
National Ranking
269

Overview

Gary D. Brayer is affiliated with the University of British Columbia in Canada and works primarily in the field of medicine, with a focused expertise in hematology. Their research interests include mechanisms of blood coagulation and thrombosis, hemophilia treatment and research, and platelet disorders and treatments.

The scientist has contributed to academic literature with works published in venues such as UNC Libraries. One notable publication is:

  • Expression and characterization of human factor IX. Factor IXthr-397 and factor IXval-397., 2021, UNC Libraries

Frequent collaborators in their research include:

  • Nobuko Hamaguchi
  • Paul S. Charifson
  • Lee G. Pedersen
  • Kenneth J. Smith
  • Darrel W. Stafford

Their scholarly output predominantly covers the following main fields and subfields:

  • Medicine
  • Hematology

Within these areas, their research topics focus on:

  • Blood Coagulation and Thrombosis Mechanisms
  • Hemophilia Treatment and Research
  • Platelet Disorders and Treatments

Best Publications

  • High-resolution three-dimensional structure of horse heart cytochrome c.

    Gordon W. Bushnell;Gordon V. Louie;Gary D. Brayer

  • High-resolution refinement of yeast iso-1-cytochrome c and comparisons with other eukaryotic cytochromes c

    Gordon V. Louie;Gary D. Brayer

  • The structure of human pancreatic alpha-amylase at 1.8 A resolution and comparisons with related enzymes.

    Gary D. Brayer;Yaoguang Luo;Stephen G. Withers

  • Oxidation state-dependent conformational changes in cytochrome c

    Albert M. Berghuis;Gary D. Brayer

  • Structure of human salivary alpha-amylase at 1.6 A resolution: implications for its role in the oral cavity.

    Narayanan Ramasubbu;Venugopalan Paloth;Yaoguang Luo;Gary D. Brayer

  • High-resolution study of the three-dimensional structure of horse heart metmyoglobin.

    Stephen V. Evans;Gary D. Brayer

  • Subsite mapping of the human pancreatic alpha-amylase active site through structural, kinetic, and mutagenesis techniques.

    Gary D. Brayer;Gary Sidhu;Robert Maurus;Edwin H. Rydberg

  • Two high-resolution crystal structures of the recombinant N-lobe of human transferrin reveal a structural change implicated in iron release.

    Ross T. A. MacGillivray;Stanley A. Moore;Jie Chen;Bryan F. Anderson

  • Hydrogen bonding and catalysis: a novel explanation for how a single amino acid substitution can change the pH optimum of a glycosidase

    Manish D. Joshi;Gary Sidhu;Isabelle Pot;Gary D. Brayer

  • Structures of product and inhibitor complexes of Streptomyces griseus protease A at 1.8 A resolution. A model for serine protease catalysis.

    M.N.G. James;A.R. Sielecki;G.D. Brayer;L.T.J. Delbaere

  • Crystal and molecular structure of paclitaxel (taxol).

    Donald Mastropaolo;Arthur Camerman;Yuogang Luo;Gary D. Brayer

  • Characterization of human blood coagulation factor XII cDNA. Prediction of the primary structure of factor XII and the tertiary structure of beta-factor XIIa.

    D E Cool;C J Edgell;G V Louie;M J Zoller

  • The Search for Novel Human Pancreatic α‐Amylase Inhibitors: High‐Throughput Screening of Terrestrial and Marine Natural Product Extracts

    Chris A. Tarling;Kate Woods;Ran Zhang;Harry C. Brastianos

  • Refined structure of alpha-lytic protease at 1.7 A resolution. Analysis of hydrogen bonding and solvent structure.

    Masao Fujinaga;Louis T.J. Delbaere;Gary D. Brayer;Michael N.G. James

  • Sugar ring distortion in the glycosyl-enzyme intermediate of a family G/11 xylanase.

    Gary Sidhu;Stephen G. Withers;Nham T. Nguyen;Lawrence P. McIntosh

  • Alternative catalytic anions differentially modulate human alpha-amylase activity and specificity

    Robert Maurus;Anjuman Begum;Leslie K Williams;Jason R Fredriksen

  • Refined structure of the gene 5 DNA binding protein from bacteriophage fd.

    Gary D. Brayer;Alexander McPherson

  • A myoglobin variant with a polar substitution in a conserved hydrophobic cluster in the heme binding pocket.

    R Maurus;C M Overall;R Bogumil;Y Luo

  • The amylase inhibitor montbretin A reveals a new glycosidase inhibition motif.

    Leslie K Williams;Xiaohua Zhang;Sami Caner;Christina Tysoe

  • Yeast iso-1-cytochrome c. A 2•8 Å resolution three-dimensional structure determination

    Gordon V. Louie;Wendy L.B. Hutcheon;Gary D. Brayer

  • Dissecting the electrostatic interactions and pH-dependent activity of a family 11 glycosidase.

    Manish D. Joshi;Gary Sidhu;Jens E. Nielsen;Gary D. Brayer

Frequent Co-Authors

Stephen G. Withers
Stephen G. Withers University of British Columbia
Dieter Brömme
Dieter Brömme University of British Columbia
Raymond J. Andersen
Raymond J. Andersen University of British Columbia
michael smith
michael smith Royal Geographical Society
Christopher M. Overall
Christopher M. Overall University of British Columbia
Michael E. P. Murphy
Michael E. P. Murphy University of British Columbia
Buford L. Nichols
Buford L. Nichols Baylor College of Medicine
Bruce R. Hamaker
Bruce R. Hamaker Purdue University West Lafayette
Michael N. G. James
Michael N. G. James University of Alberta
Alexander McPherson
Alexander McPherson University of California, Irvine

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