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Michael N. G. James

Michael N. G. James

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Chemistry
Canada
2025
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Biology and Biochemistry
Canada
2023

D-Index & Metrics

Chemistry

D-Index
91
Citations
26344
World Ranking
1996
National Ranking
47

Biology and Biochemistry

D-Index
91
Citations
25877
World Ranking
2355
National Ranking
72

Research.com Recognitions

  • 2025 - Research.com Chemistry in Canada Leader Award
  • 2023 - Research.com Biology and Biochemistry in Canada Leader Award
  • 2022 - Research.com Chemistry in Canada Leader Award

Overview

Michael N. G. James is affiliated with the University of Alberta in Canada. Their research spans across several fields related to medicine and biological sciences, with a focus on both clinical and molecular aspects of disease.

The primary fields of study for Michael N. G. James include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Within these disciplines, their work further delves into specific subfields such as:

  • Infectious Diseases
  • Biomedical Engineering
  • Animal Science and Zoology
  • Genetics
  • Neurology

Michael N. G. James has contributed to several research topics, reflecting the breadth of their scientific inquiry. Key topics covered in their research include:

  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 Clinical Research Studies
  • SARS-CoV-2 detection and testing
  • Animal Virus Infections Studies
  • Viral gastroenteritis research and epidemiology
  • Virus-based gene therapy research
  • Parkinson's Disease Mechanisms and Treatments

Their published papers illustrate the diversity of their research interests, with studies appearing in multiple scientific journals. Notable recent publications are:

  • Treatment and prevention strategies for the COVID-19 pandemic: A review of immunotherapeutic approaches for neutralizing SARS-CoV-2 (2021), International Journal of Biological Macromolecules
  • Porcine Epidemic Diarrhea: Causative Agent, Epidemiology, Clinical Characteristics, and Treatment Strategy Targeting Main Protease (2022), Protein and Peptide Letters
  • A Simplified Mathematical Model for Cell Proliferation in a Tissue-Engineering Scaffold (2024), Bulletin of Mathematical Biology
  • Where do we want the glaciological community to be in 2073? Equality, diversity and inclusion challenges and visions from the 2023 Karthaus Summer School (2025), Journal of Glaciology

Michael N. G. James frequently collaborates with other researchers in their field. Prominent co-authors include:

  • Tooba Naz Shamsi
  • Roshani Payoe
  • Taj Mohammad
  • Pravas Kumar Baral
  • Yin Jiang

Their work has been published across multiple journals, highlighting the interdisciplinary nature of their research:

  • International Journal of Biological Macromolecules
  • Protein and Peptide Letters
  • Bulletin of Mathematical Biology
  • Journal of Glaciology

Best Publications

  • Crystal structures of the helix-loop-helix calcium-binding proteins.

    Natalie C. J. Strynadka;Michael N. G. James

  • Structure of the calcium regulatory muscle protein troponin-C at 2.8 Å resolution

    Osnat Herzberg;Michael N. G. James

  • Molecular structure of the acyl-enzyme intermediate in β-lactam hydrolysis at 1.7 Å resolution

    Natalie C. J. Strynadka;Hiroyuki Adachi;Susan E. Jensen;Kathy Johns

  • Structure and refinement of penicillopepsin at 1.8 A resolution.

    Michael N.G. James;Anita R. Sielecki

  • Structural evidence for gene duplication in the evolution of the acid proteases.

    J. Tang;M. N. G. James;I. N. Hsu;J. A. Jenkins

  • Structural comparison of two serine proteinase-protein inhibitor complexes: eglin-c-subtilisin Carlsberg and CI-2-subtilisin Novo.

    Catherine A. McPhalen;Michael N. G. James

  • Picornaviral 3C cysteine proteinases have a fold similar to chymotrypsin-like serine proteinases

    Marc Allaire;Maia M. Chernaia;Bruce A. Malcolm;Michael N. G. James

  • Structure of shiga toxin type 2 (Stx2) from escherichia coli O157:H7

    Marie E. Fraser;Masao Fujinaga;Maia M. Cherney;Angela R. Melton-Celsa

  • Crystal structure of the holotoxin from Shigella dysenteriae at 2.5 A resolution.

    Marie E. Fraser;Maia M. Chernaia;Yuri V. Kozlov;Michael N.G. James

  • Refined crystal structure of troponin C from turkey skeletal muscle at 2·0 Å resolution

    Osnat Herzberg;Michael N.G. James

  • Molecular structure of an aspartic proteinase zymogen, porcine pepsinogen, at 1.8 Å resolution

    Michael N. G. James;Anita R. Sielecki

  • Crystallographic evidence for substrate-assisted catalysis in a bacterial beta-hexosaminidase.

    Brian L. Mark;David J. Vocadlo;Spencer Knapp;Barbara L. Triggs-Raine

  • A model for the Ca2+-induced conformational transition of troponin C. A trigger for muscle contraction.

    O Herzberg;J Moult;M N James

  • Molecular and crystal structures of monoclinic porcine pepsin refined at 1.8 A resolution.

    Anita R. Sielecki;Alexander A. Fedorov;Amechand Boodhoo;Natalia S. Andreeva

  • An algorithm for determining the conformation of polypeptide segments in proteins by systematic search.

    J. Moult;M. N. G. James

  • Calcium-binding sites in proteins: a structural perspective.

    Catherine A. McPhalen;Natalie C.J. Strynadka;Michael N.G. James

  • LYSOZYME REVISITED : CRYSTALLOGRAPHIC EVIDENCE FOR DISTORTION OF AN N-ACETYLMURAMIC ACID RESIDUE BOUND IN SITE D

    Natalie C.J. Strynadka;Michael N.G. James

  • Crystal and molecular structures of the complex of alpha-chymotrypsin with its inhibitor turkey ovomucoid third domain at 1.8 A resolution.

    Masao Fujinaga;Anita R. Sielecki;Randy J. Read;Wojciech Ardelt

  • Structures of product and inhibitor complexes of Streptomyces griseus protease A at 1.8 A resolution. A model for serine protease catalysis.

    M.N.G. James;A.R. Sielecki;G.D. Brayer;L.T.J. Delbaere

  • Crystal Structure of Human β-Hexosaminidase B: Understanding the Molecular Basis of Sandhoff and Tay-Sachs Disease

    Brian L. Mark;Don J. Mahuran;Maia M. Cherney;Dalian Zhao

  • Structure of Shiga toxin type 2 (Stx2) from Escherichia coli O157:H7. VOLUME 279 (2004) PAGES 27511-27517

    Marie E. Fraser;Masao Fujinaga;Maia M. Cherney;Angela R. Melton-Celsa

Frequent Co-Authors

John C. Vederas
John C. Vederas University of Alberta
Natalie C. J. Strynadka
Natalie C. J. Strynadka University of British Columbia
Randy J. Read
Randy J. Read University of Cambridge
Adriano Aguzzi
Adriano Aguzzi University of Zurich
Osnat Herzberg
Osnat Herzberg University of Maryland, College Park
Don J. Mahuran
Don J. Mahuran University of Toronto
Lindsay D. Eltis
Lindsay D. Eltis University of British Columbia
Stephen G. Withers
Stephen G. Withers University of British Columbia
Michael Laskowski
Michael Laskowski Purdue University West Lafayette
Charles F. B. Holmes
Charles F. B. Holmes University of Alberta

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