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Biology and Biochemistry

D-Index
55
Citations
19890
World Ranking
14762
National Ranking
6170

Overview

Lixin Zheng is a researcher affiliated with the National Institutes of Health in the United States. Their work spans multiple fields, primarily focusing on immunology and microbiology, with additional contributions to biochemistry, genetics, molecular biology, and medicine. Zheng's research is distributed across various subfields, including immunology, molecular biology, genetics, infectious diseases, and neurology.

Their main research topics cover several aspects of immune system function and disorders. Key areas of study include:

  • Immune Cell Function and Interaction
  • Immunotherapy and Immune Responses
  • Immunodeficiency and Autoimmune Disorders
  • Immune Response and Inflammation
  • Inflammasome and immune disorders
  • Diabetes and associated disorders
  • T-cell and B-cell Immunology

Zheng has published extensively in reputed scientific venues. Frequent publication outlets include:

  • Nature Immunology
  • Science Advances
  • Vaccines
  • Cell
  • Cell Reports

Their recent papers illustrate diverse research interests and provide insight into specific contributions:

  • "Progress and Prospects on Vaccine Development against SARS-CoV-2," 2020, Vaccines
  • "Mucus sialylation determines intestinal host-commensal homeostasis," 2022, Cell
  • "Characterization of Resident Corneal Plasmacytoid Dendritic Cells and Their Pivotal Role in Herpes Simplex Keratitis," 2020, Cell Reports
  • "CD1d1 intrinsic signaling in macrophages controls NLRP3 inflammasome expression during inflammation," 2020, Science Advances
  • "Injectable host-guest gel nanovaccine for cancer immunotherapy against melanoma," 2022, Materials Today Advances

Collaborations have been a significant part of Zheng's research activity. Frequent co-authors include:

  • Michael J. Lenardo
  • Yikun Yao
  • Ann Y. Park
  • Satoshi Kubo
  • Ping Jiang

In addition to journal articles, Zheng has contributed to the academic literature through book publications. Notably, a book published by Frontiers Media titled Orthodox vs Paradox: The Roles of Glycomics, Genetics and Beyond in Immunity, Immune Disorders and Glycomedicine was released in 2023.

Best Publications

  • Termination of autophagy and reformation of lysosomes regulated by mTOR

    Li Yu;Christina K. McPhee;Christina K. McPhee;Lixin Zheng;Gonzalo A. Mardones;Gonzalo A. Mardones

  • CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation–mediated apoptosis of effector CD4+ T cells

    Pushpa Pandiyan;Lixin Zheng;Satoru Ishihara;Jennifer Reed

  • Induction of apoptosis in mature T cells by tumour necrosis factor.

    Lixin Zheng;Galen Fisher;Robert E. Miller;Jacques Peschon

  • A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling.

    Francis Ka-Ming Chan;Hyung J. Chun;Lixin Zheng;Richard M. Siegel

  • Mature T lymphocyte apoptosis--immune regulation in a dynamic and unpredictable antigenic environment.

    M Lenardo;K M Chan;F Hornung;H McFarland

  • Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency

    Hyung J. Chun;Lixin Zheng;Manzoor Ahmad;Jin Wang;Jin Wang

  • Inherited Human Caspase 10 Mutations Underlie Defective Lymphocyte and Dendritic Cell Apoptosis in Autoimmune Lymphoproliferative Syndrome Type II

    Jin Wang;Lixin Zheng;Adrian Lobito;Francis Ka Ming Chan

  • Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy

    Bernice Lo;Kejian Zhang;Wei Lu;Lixin Zheng

  • A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses.

    Francis Ka Ming Chan;Francis Ka Ming Chan;Joanna L. Shisler;Jacqueline G. Bixby;Martin Felices

  • Membrane Oligomerization and Cleavage Activates the Caspase-8 (FLICE/MACHα1) Death Signal

    David A. Martin;Richard M. Siegel;Lixin Zheng;Michael J. Lenardo

  • Requirement for Caspase-8 in NF-κB Activation by Antigen Receptor

    Helen Su;Nicolas Bidère;Lixin Zheng;Alan Cubre

  • Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis.

    Hyung J. Chun;Ziad A. Ali;Yoko Kojima;Ramendra K. Kundu

  • Ribosomal Protein S3: A KH Domain Subunit in NF-κB Complexes that Mediates Selective Gene Regulation

    Fengyi Wan;D. Eric Anderson;Robert A. Barnitz;Andrew Snow

  • E2 interaction and dimerization in the crystal structure of TRAF6

    Qian Yin;Su Chang Lin;Betty Lamothe;Miao Lu

  • Mg2+ Regulates Cytotoxic Functions of NK and CD8 T Cells in Chronic EBV Infection Through NKG2D

    Benjamin Chaigne-Delalande;Feng-Yen Li;Feng-Yen Li;Geraldine M. O’Connor;Marshall J. Lukacs

  • CD4+CD25+Foxp3+ Regulatory T Cells Promote Th17 Cells In Vitro and Enhance Host Resistance in Mouse Candida albicans Th17 Cell Infection Model

    Pushpa Pandiyan;Heather R. Conti;Lixin Zheng;Alanna C. Peterson

  • NMR structure and mutagenesis of the FADD (Mort1) death-effector domain.

    Matthias Eberstadt;Baohua Huang;Zehan Chen;Robert P. Meadows

  • The death effector domain protein family: regulators of cellular homeostasis

    Michael D Tibbetts;Lixin Zheng;Michael J Lenardo

  • Death-effector Filaments: Novel Cytoplasmic Structures that Recruit Caspases and Trigger Apoptosis

    Richard M. Siegel;David A. Martin;Lixin Zheng;Samuel Y. Ng

  • NRAS mutation causes a human autoimmune lymphoproliferative syndrome

    João B. Oliveira;Nicolas Bidère;Julie E. Niemela;Lixin Zheng

Frequent Co-Authors

Michael J. Lenardo
Michael J. Lenardo National Institute of Allergy and Infectious Diseases
Richard M. Siegel
Richard M. Siegel National Institutes of Health
Sharon E. Straus
Sharon E. Straus University of Toronto
Jin Wang
Jin Wang Houston Methodist
Helen C. Su
Helen C. Su National Institutes of Health
Jennifer M. Puck
Jennifer M. Puck University of California, San Francisco
Stefania Pittaluga
Stefania Pittaluga National Institutes of Health
Francis Ka-Ming Chan
Francis Ka-Ming Chan Duke University
Marcus E. Peter
Marcus E. Peter Northwestern University
Louis M. Staudt
Louis M. Staudt National Institutes of Health

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