World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
55
Citations
14168
World Ranking
14855
National Ranking
6213

Overview

Laurent Vergnes is affiliated with the University of California, Los Angeles in the United States. Their research portfolio spans multiple areas within biochemistry, genetics, molecular biology, and medicine, focusing particularly on molecular biology, physiology, cancer research, biochemistry, and genetics as prominent subfields.

The scientist's main research topics include adipose tissue and metabolism, mitochondrial function and pathology, lipid metabolism and biosynthesis, peroxisome proliferator-activated receptors, RNA research and splicing, RNA modifications and cancer, and interferon and immune responses.

Vergnes has published extensively in several venues, with frequent contributions to bioRxiv (Cold Spring Harbor Laboratory), Nature Metabolism, Nature, Nature Communications, and Scientific Reports. These publications reflect a focus on molecular and cellular mechanisms underlying metabolic and physiological processes.

Several notable recent papers illustrate Laurent Vergnes's research interests and areas of contribution:

  • A novel approach to measure mitochondrial respiration in frozen biological samples (2020, The EMBO Journal)
  • Creatine kinase B controls futile creatine cycling in thermogenic fat (2021, Nature)
  • X chromosome dosage of histone demethylase KDM5C determines sex differences in adiposity (2020, Journal of Clinical Investigation)
  • Estrogen receptor α controls metabolism in white and brown adipocytes by regulating Polg1 and mitochondrial remodeling (2020, Science Translational Medicine)
  • Sex differences in heart mitochondria regulate diastolic dysfunction (2022, Nature Communications)

Collaborations with other researchers form an important part of Vergnes's scientific output. Frequent coauthors include Karen Reue, Aldons J. Lusis, Orian S. Shirihai, Carrie B. Wiese, and Rebeca Acín-Pérez.

Best Publications

  • Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

    Kenichi Shimada;Timothy R. Crother;Justin Karlin;Jargalsaikhan Dagvadorj

  • The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR

    Randall M. Chin;Xudong Fu;Melody Y. Pai;Laurent Vergnes

  • Sterol regulatory element–binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity

    Yoko Kidani;Heidi Elsaesser;M Benjamin Hock;M Benjamin Hock;Laurent Vergnes

  • Metabolic state of glioma stem cells and nontumorigenic cells

    Erina Vlashi;Chann Lagadec;Laurent Vergnes;Tomoo Matsutani

  • UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells

    Jin Zhang;Ivan Khvorostov;Jason S. Hong;Yavuz Oktay

  • Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling

    Autumn G. York;Kevin J. Williams;Joseph P. Argus;Quan D. Zhou

  • Lamin B1 is required for mouse development and nuclear integrity.

    Laurent Vergnes;Miklós Péterfy;Martin O. Bergo;Stephen G. Young

  • Measuring energy metabolism in cultured cells, including human pluripotent stem cells and differentiated cells

    Jin Zhang;Esther Nuebel;Dona R R Wisidagama;Kiyoko Setoguchi

  • Cholesterol and cholate components of an atherogenic diet induce distinct stages of hepatic inflammatory gene expression.

    Laurent Vergnes;Laurent Vergnes;Jack Phan;Jack Phan;Merav Strauss;Sherrie Tafuri

  • Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons.

    Catherine Coffinier;Hea-Jin Jung;Chika Nobumori;Sandy Chang

  • 2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling.

    Xudong Fu;Randall M. Chin;Laurent Vergnes;Heejun Hwang

  • An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity.

    Kevin J. Williams;Joseph P. Argus;Yue Zhu;Moses Q. Wilks

  • Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females

    Vicent Ribas;Brian G. Drew;Zhenqi Zhou;Jennifer Phun

  • Paraoxonase 2 deficiency alters mitochondrial function and exacerbates the development of atherosclerosis.

    Asokan Devarajan;Noam Bourquard;Susan Hama;Mohamad Navab

  • Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis

    Haruko Nakano;Itsunari Minami;Daniel Braas;Herman Pappoe

  • Antioxidative and Antiatherosclerotic Effects of Human Apolipoprotein A-IV in Apolipoprotein E–Deficient Mice

    Maria A. Ostos;Mariangela Conconi;Laurent Vergnes;Nadine Baroukh

  • Succinate dehydrogenase inhibition leads to epithelial-mesenchymal transition and reprogrammed carbon metabolism

    Paul-Joseph P Aspuria;Sophia Y Lunt;Sophia Y Lunt;Leif Väremo;Laurent Vergnes

  • Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity.

    Laurent Vergnes;Anne P. Beigneux;Ryan Davis;Steven M. Watkins

  • Biologic evaluation of curcumin and structural derivatives in cancer chemoprevention model systems

    Stefan Gafner;Sang-Kook Lee;Muriel Cuendet;Sophie Barthélémy

  • Erratum: UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells (EMBO Journal (2011) 30 (4860-4873) DOI:10.1038/emboj.2011.401)

    Jin Zhang;Ivan Khvorostov;Jason S. Hong;Yavuz Oktay

Frequent Co-Authors

Karen Reue
Karen Reue University of California, Los Angeles
Aldons J. Lusis
Aldons J. Lusis University of California, Los Angeles
Peter Tontonoz
Peter Tontonoz University of California, Los Angeles
Stephen G. Young
Stephen G. Young University of California, Los Angeles
Loren G. Fong
Loren G. Fong University of California, Los Angeles
Michael A. Teitell
Michael A. Teitell University of California, Los Angeles
Beth Y. Karlan
Beth Y. Karlan University of California, Los Angeles
Srinivasa T. Reddy
Srinivasa T. Reddy University of California, Los Angeles
Margarete Mehrabian
Margarete Mehrabian University of California, Los Angeles
Xia Yang
Xia Yang University of California, Los Angeles

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring Biology and Biochemistry opens doors to diverse online degree programs and exciting career options in health and science. If you’re interested in nutrition, there are best online registered dietitian programs designed for those who want to become licensed dietitians and nutrition experts.

For nursing professionals, furthering your education can be cost-effective and flexible. Many pursue the cheapest rn to bsn online programs to expand their qualifications and improve career prospects.

If your interests lie in management, there are fast online master's in healthcare management options, ideal for advancing into leadership positions in health organizations.

For those drawn to mental health, pursuing psych np programs can prepare you for rewarding roles as psychiatric nurse practitioners.

With these online options, students can advance their careers while balancing personal and professional commitments—all while staying connected to the biological sciences.

Best Scientists Citing Laurent Vergnes

Trending Scientists