Neil Upton

Best Publications

• Orexin A activates locus coeruleus cell firing and increases arousal in the rat

  J.J. Hagan;R.A. Leslie;S. Patel;M.L. Evans

  1419
  Citations

• SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist.

  G.A. Kennett;M.D. Wood;F. Bright;B. Trail

  786
  Citations

• The novel brain neuropeptide, orexin-A, modulates the sleep-wake cycle of rats.

  David C. Piper;Neil Upton;Martin I. Smith;A. Jackie Hunter

  513
  Citations

• GSK189254, a Novel H3 Receptor Antagonist That Binds to Histamine H3 Receptors in Alzheimer's Disease Brain and Improves Cognitive Performance in Preclinical Models

  Andrew D. Medhurst;Alan R. Atkins;Isabel J. Beresford;Kim Brackenborough

  421
  Citations

• Characterization of SB‐269970‐A, a selective 5‐HT7 receptor antagonist

  Jim J Hagan;Gary W Price;Phillip Jeffrey;Nigel J Deeks

  348
  Citations

• Epileptogenesis and enhanced prepulse inhibition in GABA(B1)-deficient mice.

  Haydn M. Prosser;Catherine H. Gill;Warren D. Hirst;Evelyn Grau

  333
  Citations

• SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models.

  Warren D. Hirst;Tania O. Stean;Derek C. Rogers;David Sunter

  312
  Citations

• 5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer's disease.

  Neil Upton;Tsu Tshen Chuang;Ann J. Hunter;David J. Virley

  308
  Citations

• SB-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-A in rats

  R. J. Rodgers;J. C. G. Halford;R. L. Nunes de Souza;A. L. Canto de Souza

  286
  Citations

• Characterization of SB-271046 : A potent, selective and orally active 5-HT6 receptor antagonist

  Carol Routledge;Steven M Bromidge;Stephen F Moss;Gary W Price

  212
  Citations

• BACE1 (β-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes

  Steve M Harrison;Alex J Harper;Julie Hawkins;Graham Duddy

  211
  Citations

• Non-cognitive behaviours in an APP/PS1 transgenic model of Alzheimer's disease

  Perdita L. Pugh;Jill C. Richardson;Simon T. Bate;Neil Upton

  183
  Citations

• The 5-HT 6 Receptor Antagonist SB-271046 Reverses Scopolamine-Disrupted Consolidation of a Passive Avoidance Task and Ameliorates Spatial Task Deficits in Aged Rats

  Andrew G Foley;Keith J Murphy;Warren D Hirst;Helen C Gallagher

  162
  Citations

• A simultaneous ERP/fMRI investigation of the P300 aging effect

  Redmond G. O'Connell;Joshua H. Balsters;Sophia M. Kilcullen;William Campbell

  161
  Citations

• The PPARγ agonist pioglitazone is effective in the MPTP mouse model of Parkinson's disease through inhibition of monoamine oxidase B

  L P Quinn;B Crook;M E Hows;M Vidgeon-Hart

  143
  Citations

• GABAB receptor isoforms GBR1a and GBR1b, appear to be associated with pre- and post-synaptic elements respectively in rat and human cerebellum

  Andrew Billinton;Neil Upton;Norman G Bowery

  142
  Citations

• (R)-3,N-dimethyl-N-[1-methyl-3-(4-methyl-piperidin-1-yl) propyl]benzenesulfonamide: the first selective 5-HT7 receptor antagonist.

  Forbes It;Dabbs S;Duckworth Dm;Jennings Aj

  139
  Citations

• Effects of centrally administered orexin-B and orexin-A: a role for orexin-1 receptors in orexin-B-induced hyperactivity.

  D N Jones;J Gartlon;F Parker;S G Taylor

  134
  Citations

• Evidence that orexin-A-evoked grooming in the rat is mediated by orexin-1 (OX1) receptors, with downstream 5-HT2C receptor involvement.

  Mark S. Duxon;Jennifer Stretton;Kathryn Starr;Declan N.C. Jones

  132
  Citations

• Circadian and dark-pulse activation of orexin/hypocretin neurons

  Oliver J Marston;Rhîannan H Williams;Maria M Canal;Rayna E Samuels

  128
  Citations

• Pittsburgh compound B (11C-PIB) and fluorodeoxyglucose (18 F-FDG) PET in patients with Alzheimer disease, mild cognitive impairment, and healthy controls.

  D.P. Devanand;Arthur Mikhno;Gregory H. Pelton;Katrina Cuasay

  125
  Citations

• Evidence implicating a role for orexin-1 receptor modulation of paradoxical sleep in the rat

  M.I Smith;D.C Piper;M.S Duxon;N Upton

  119
  Citations