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Neuroscience

D-Index
79
Citations
32745
World Ranking
1656
National Ranking
810

Overview

Thomas E. Scammell is affiliated with Harvard Medical School in the United States and has a significant body of research primarily focused on the neuroscience of sleep and related disorders. Their work spans several subfields within neuroscience and psychology, emphasizing sleep and wakefulness research as well as circadian rhythms and melatonin regulation.

The scientist has contributed extensively to the study of sleep and related disorders, with main research topics including:

  • Sleep and Wakefulness Research
  • Sleep and related disorders
  • Circadian rhythm and melatonin
  • Neuroscience of respiration and sleep
  • Restless Legs Syndrome Research
  • Regulation of Appetite and Obesity
  • Pain Mechanisms and Treatments

Thomas E. Scammell's research falls under the broader fields of Neuroscience and Psychology, with particular attention to:

  • Cognitive Neuroscience
  • Experimental and Cognitive Psychology
  • Endocrine and Autonomic Systems
  • Genetics
  • Epidemiology

Their published work appears frequently in several key venues, including:

  • SLEEP
  • Zenodo (CERN European Organization for Nuclear Research)
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Sleep Medicine
  • Nature Communications

Notable recent papers include:

  • "Orexin neurons inhibit sleep to promote arousal," 2022, Nature Communications
  • "Oral Orexin Receptor 2 Agonist in Narcolepsy Type 1," 2023, New England Journal of Medicine
  • "Clinical considerations for the diagnosis of idiopathic hypersomnia," 2022, Sleep Medicine Reviews
  • "Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity," 2021, Nature Communications
  • "Defining disrupted nighttime sleep and assessing its diagnostic utility for pediatric narcolepsy type 1," 2020, SLEEP

Their collaborative network includes frequent co-authors such as:

  • Kiran Maski
  • Elda Arrigoni
  • Yves Dauvilliers
  • Cecilia Diniz Behn
  • Roberto De Luca

Best Publications

  • Narcolepsy in orexin knockout mice: Molecular genetics of sleep regulation

    Richard M. Chemelli;Jon T. Willie;Christopher M. Sinton;Joel K. Elmquist

  • Hypothalamic regulation of sleep and circadian rhythms

    Clifford B. Saper;Thomas E. Scammell;Jun Lu

  • The sleep switch: hypothalamic control of sleep and wakefulness

    Clifford B Saper;Thomas C Chou;Thomas E Scammell

  • Sleep State Switching

    Clifford B. Saper;Patrick M. Fuller;Nigel P. Pedersen;Jun Lu

  • Neural Circuitry of Wakefulness and Sleep

    Thomas E. Scammell;Thomas E. Scammell;Elda Arrigoni;Jonathan O. Lipton

  • Fos expression in orexin neurons varies with behavioral state.

    Ivy V. Estabrooke;Marie T. McCarthy;Emily Ko;Thomas C. Chou

  • Melanopsin in cells of origin of the retinohypothalamic tract.

    Joshua J. Gooley;Jun Lu;Thomas C. Chou;Thomas E. Scammell

  • Afferents to the Orexin Neurons of the Rat Brain

    Kyoko Yoshida;Sarah McCormack;Rodrigo A. España;Amanda Crocker

  • Critical Role of Dorsomedial Hypothalamic Nucleus in a Wide Range of Behavioral Circadian Rhythms

    Thomas C. Chou;Thomas E. Scammell;Joshua J. Gooley;Stephanie E. Gaus

  • Regulation of Daily Locomotor Activity and Sleep by Hypothalamic EGF Receptor Signaling

    Achim Kramer;Fu-Chia Yang;Pamela Snodgrass;Xiaodong Li

  • Afferents to the ventrolateral preoptic nucleus.

    Thomas C. Chou;Alvhild A. Bjorkum;Stephanie E. Gaus;Jun Lu

  • Hypothalamic Arousal Regions Are Activated during Modafinil-Induced Wakefulness

    Thomas E. Scammell;Ivy V. Estabrooke;Marie T. McCarthy;Richard M. Chemelli

  • Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatment.

    Claudio L. A. Bassetti;Antoine Adamantidis;Denis Burdakov;Denis Burdakov;Denis Burdakov;Fang Han

  • Homeostatic, circadian, and emotional regulation of sleep.

    Clifford B. Saper;Georgina Cano;Thomas E. Scammell

  • Orexin (hypocretin) neurons contain dynorphin.

    Thomas C. Chou;Charlotte E. Lee;J. Lu;Joel K. Elmquist

  • Mechanisms of CNS response to systemic immune challenge: the febrile response

    Joel K. Elmquist;Thomas E. Scammell;Clifford B. Saper

  • Behavioral State Instability in Orexin Knock-Out Mice

    Takatoshi Mochizuki;Amanda Crocker;Sarah McCormack;Masashi Yanagisawa

  • Sleep modulates haematopoiesis and protects against atherosclerosis.

    Cameron S. McAlpine;Máté G. Kiss;Máté G. Kiss;Máté G. Kiss;Sara Rattik;Shun He

  • Orexin Receptors: Pharmacology and Therapeutic Opportunities

    Thomas E. Scammell;Christopher J. Winrow

  • Distribution of Fos-like immunoreactivity in the rat brain following intravenous lipopolysaccharide administration.

    Joel K. Elmquist;Thomas E. Scammell;Carol D. Jacobson;Clifford B. Saper

  • An adenosine A2a agonist increases sleep and induces Fos in ventrolateral preoptic neurons

    T.E Scammell;D.Y Gerashchenko;T Mochizuki;M.T McCarthy

  • Narcolepsy.

    Unknown

Frequent Co-Authors

Clifford B. Saper
Clifford B. Saper Beth Israel Deaconess Medical Center
Takatoshi Mochizuki
Takatoshi Mochizuki Beth Israel Deaconess Medical Center
Elda Arrigoni
Elda Arrigoni Harvard Medical School
Gert Jan Lammers
Gert Jan Lammers Leiden University
Claudio L. Bassetti
Claudio L. Bassetti University of Bern
Jun Lu
Jun Lu Zhejiang University
Rodrigo A. España
Rodrigo A. España Drexel University
Bradford B. Lowell
Bradford B. Lowell Beth Israel Deaconess Medical Center
Yves Dauvilliers
Yves Dauvilliers University of Montpellier
Jon T. Willie
Jon T. Willie Washington University in St. Louis

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