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D-Index & Metrics

Psychology

D-Index
67
Citations
12170
World Ranking
2631
National Ranking
156

Medicine

D-Index
71
Citations
13339
World Ranking
20038
National Ranking
843

Overview

Paul J. Fletcher is affiliated with the Centre for Addiction and Mental Health in Canada. Their research primarily spans the fields of Medicine and Neuroscience, with a focus on subfields such as Cellular and Molecular Neuroscience, Clinical Psychology, Pharmacology, Molecular Biology, and Physiology.

Their work addresses several key topics within these domains, including:

  • Neurotransmitter Receptor Influence on Behavior
  • Regulation of Appetite and Obesity
  • Cannabis and Cannabinoid Research
  • Receptor Mechanisms and Signaling
  • Psychedelics and Drug Studies
  • Pharmacology and Obesity Treatment
  • Schizophrenia research and treatment

Fletcher's recent publications include the following papers:

  • "Use of Immersive Virtual Reality in the Assessment and Treatment of Alzheimer's Disease: A Systematic Review," 2020, Journal of Alzheimer s Disease
  • "Once-Weekly Semaglutide in Adults With Alcohol Use Disorder," 2025, JAMA Psychiatry
  • "Median raphe serotonin neurons promote anxiety-like behavior via inputs to the dorsal hippocampus," 2020, Neuropharmacology
  • "Effects of exposure to chronic uncertainty and a sensitizing regimen of amphetamine injections on locomotion, decision-making, and dopamine receptors in rats," 2020, Neuropsychopharmacology
  • "Clozapine reliably increases the motivation for food: parsing the role of the 5-HT2c and H1 receptors," 2020, Psychopharmacology

Frequent co-authors collaborating with Fletcher include:

  • Zhaoxia Li
  • Anh D. Lê
  • Andrew R. Abela
  • Arya Rahbarnia
  • Douglas Funk

The research outputs of Fletcher have been frequently published in venues such as Psychopharmacology, Neuropharmacology, bioRxiv (Cold Spring Harbor Laboratory), Journal of Alzheimer s Disease, and JAMA Psychiatry.

Best Publications

  • Reinstatement of alcohol-seeking by priming injections of alcohol and exposure to stress in rats

    A D Lê;B Quan;W Juzytch;P J Fletcher

  • Antidepressant-Like Effects of Medial Prefrontal Cortex Deep Brain Stimulation in Rats

    Clement Hamani;Clement Hamani;Mustansir Diwan;Carlos E. Macedo;Marcus L. Brandão

  • Differential Effects of the 5-HT2A Receptor Antagonist M100,907 and the 5-HT2C Receptor Antagonist SB242,084 on Cocaine-induced Locomotor Activity, Cocaine Self-administration and Cocaine-induced Reinstatement of Responding

    Paul J Fletcher;Andrew J Grottick;Guy A Higgins

  • Cannabidiol, a non‐psychotropic component of cannabis, attenuates vomiting and nausea‐like behaviour via indirect agonism of 5‐HT1A somatodendritic autoreceptors in the dorsal raphe nucleus

    EM Rock;D Bolognini;CL Limebeer;MG Cascio

  • Dopamine transporter cell surface localization facilitated by a direct interaction with the dopamine D2 receptor

    Frank J S Lee;Lin Pei;Anna Moszczynska;Brian Vukusic

  • The amphetamine-induced sensitized state as a model of schizophrenia.

    R.E. Featherstone;S. Kapur;S. Kapur;P.J. Fletcher;P.J. Fletcher

  • Studies to investigate the role of 5-HT(2C) receptors on cocaine- and food-maintained behavior.

    Andrew J. Grottick;Paul J. Fletcher;Guy A. Higgins

  • Opposing effects of 5-HT(2A) and 5-HT(2C) receptor antagonists in the rat and mouse on premature responding in the five-choice serial reaction time test.

    Paul J. Fletcher;Paul J. Fletcher;Maria Tampakeras;Judy Sinyard;Guy A. Higgins

  • Dissociation between in vivo occupancy and functional antagonism of dopamine D2 receptors: comparing aripiprazole to other antipsychotics in animal models

    Sridhar Natesan;Greg E Reckless;José N Nobrega;José N Nobrega;Paul J Fletcher;Paul J Fletcher

  • The Dopamine D1-D2 Receptor Heteromer Localizes in Dynorphin/Enkephalin Neurons: INCREASED HIGH AFFINITY STATE FOLLOWING AMPHETAMINE AND IN SCHIZOPHRENIA *

    Melissa L. Perreault;Melissa L. Perreault;Ahmed Hasbi;Ahmed Hasbi;Mohammed Alijaniaram;Mohammed Alijaniaram;Theresa Fan;Theresa Fan

  • Disruption of dopamine D1 receptor gene expression attenuates alcohol-seeking behavior

    Mufida El-Ghundi;Susan R George;John Drago;Paul J Fletcher

  • Abnormalities in brain structure and behavior in GSK-3alpha mutant mice

    Oksana Kaidanovich-Beilin;Tatiana Lipina;Keizo Takao;Matthijs C van Eede

  • The 5-HT2A receptor antagonist M100,907 attenuates motor and 'impulsive-type' behaviours produced by NMDA receptor antagonism

    Guy A. Higgins;Michel Enderlin;Marie Haman;Paul J. Fletcher

  • Serotonin and drug reward: focus on 5-HT2C receptors.

    Guy A Higgins;Paul J Fletcher

  • Uncoupling the dopamine D1-D2 receptor complex exerts antidepressant-like effects

    Lin Pei;Shupeng Li;Min Wang;Mustansir Diwan

  • Spatial learning deficit in dopamine D1 receptor knockout mice

    Mufida El-Ghundi;Paul J Fletcher;John Drago;David R Sibley

  • The Role of Corticotropin-Releasing Factor in the Median Raphe Nucleus in Relapse to Alcohol

    A. D. Lê;S. Harding;W. Juzytsch;P. J. Fletcher

  • Reduced fear and aggression and altered serotonin metabolism in Gtf2ird1-targeted mice.

    E. J. Young;T. Lipina;E. Tam;A. Mandel

  • Sensitization to amphetamine, but not PCP, impairs attentional set shifting: reversal by a D1 receptor agonist injected into the medial prefrontal cortex.

    Paul J. Fletcher;Paul J. Fletcher;Catherine C. Tenn;Catherine C. Tenn;Zoë Rizos;Vedran Lovic

  • The 5-HT2C receptor agonist Ro60-0175 reduces cocaine self-administration and reinstatement induced by the stressor yohimbine, and contextual cues.

    Paul J Fletcher;Paul J Fletcher;Zoë Rizos;Judy Sinyard;Maria Tampakeras

  • The Nicotinic Acetylcholine Receptor α5 Subunit Plays a Key Role in Attention Circuitry and Accuracy

    Craig D. C. Bailey;Mariella De Biasi;Paul J. Fletcher;Evelyn K. Lambe

  • The 5-HT2C receptor agonist lorcaserin reduces nicotine self-administration, discrimination, and reinstatement: relationship to feeding behavior and impulse control.

    Guy A Higgins;Leo B Silenieks;Anne Rossmann;Zoe Rizos

Frequent Co-Authors

Gary Remington
Gary Remington Centre for Addiction and Mental Health
Shitij Kapur
Shitij Kapur King's College London
José N. Nobrega
José N. Nobrega Centre for Addiction and Mental Health
Susan R. George
Susan R. George University of Toronto
Fang Liu
Fang Liu Centre for Addiction and Mental Health
Brian F. O'Dowd
Brian F. O'Dowd Centre for Addiction and Mental Health
John C. Roder
John C. Roder University of Toronto
George Foussias
George Foussias Centre for Addiction and Mental Health
Clement Hamani
Clement Hamani University of Toronto
Martin Zack
Martin Zack University of Toronto

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