2023 - Research.com Medicine in Japan Leader Award
His scientific interests lie mostly in Internal medicine, Endocrinology, Orexin, Neuroscience and Neuropeptide. He usually deals with Internal medicine and limits it to topics linked to Non-rapid eye movement sleep and Sleep onset and Sleep Stages. His Endocrinology research incorporates elements of Transgene, Neuropeptide Y receptor and Almorexant.
His Orexin research incorporates themes from Wakefulness, Energy homeostasis and Narcolepsy. His research in Neuroscience intersects with topics in Glutamate receptor and Raphe nuclei. Within one scientific family, Takeshi Sakurai focuses on topics pertaining to In situ hybridization under Neuropeptide, and may sometimes address concerns connected to G protein-coupled receptor.
His main research concerns Internal medicine, Orexin, Endocrinology, Neuroscience and Wakefulness. His study connects Cardiology and Internal medicine. The Orexin study combines topics in areas such as Hypothalamus, Energy homeostasis and Narcolepsy.
His work investigates the relationship between Endocrinology and topics such as Receptor that intersect with problems in Molecular biology. His study in Sleep in non-human animals, Arousal, GABAergic, Neuron and Excitatory postsynaptic potential is carried out as part of his studies in Neuroscience. His research on Wakefulness often connects related areas such as Non-rapid eye movement sleep.
Takeshi Sakurai spends much of his time researching Neuroscience, Orexin, Endocrinology, Internal medicine and Wakefulness. His work on Neuroscience deals in particular with GABAergic, Optogenetics, Sleep in non-human animals, Preoptic area and Inhibitory postsynaptic potential. The study incorporates disciplines such as Lateral hypothalamus and Narcolepsy in addition to Orexin.
Takeshi Sakurai studied Endocrinology and Glutamate receptor that intersect with Prefrontal cortex. All of his Internal medicine and Excitatory postsynaptic potential, Insulin resistance, Leptin, Metabolism and Carbohydrate metabolism investigations are sub-components of the entire Internal medicine study. His study in Wakefulness is interdisciplinary in nature, drawing from both Hypothalamus, Locus coeruleus, Energy homeostasis and Non-rapid eye movement sleep.
The scientist’s investigation covers issues in Orexin, Neuroscience, Internal medicine, Endocrinology and Wakefulness. His studies deal with areas such as Hypothalamus, Lateral hypothalamus and Narcolepsy as well as Orexin. When carried out as part of a general Internal medicine research project, his work on Receptor, Glutamate receptor, Circadian rhythm and Leptin is frequently linked to work in Sequestosome 1, therefore connecting diverse disciplines of study.
His work deals with themes such as Feeding behavior, Slice preparation, Arousal and Sensory system, which intersect with Wakefulness. His Orexin receptor research focuses on subjects like Suvorexant, which are linked to Neuroscience of sleep. Takeshi Sakurai combines subjects such as Autonomic nervous system and Energy homeostasis with his study of Orexin-A.
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Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior
Takeshi Sakurai;Akira Amemiya;Makoto Ishii;Ichiyo Matsuzaki.
Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor.
Takeshi Sakurai;Masashi Yanagisawa;Yoh Takuwa;Hitoshi Miyazaki.
Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity
Junko Hara;Carsten T. Beuckmann;Tadahiro Nambu;Jon T. Willie.
Autism genome-wide copy number variation reveals ubiquitin and neuronal genes
Joseph T. Glessner;Kai Wang;Guiqing Cai;Olena Korvatska.
Distribution of orexin neurons in the adult rat brain.
Tadahiro Nambu;Takeshi Sakurai;Katsuyoshi Mizukami;Yasuhiko Hosoya.
Brain Research (1999)
Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems
Yukari Date;Yoichi Ueta;Hiroshi Yamashita;Hideki Yamaguchi.
Proceedings of the National Academy of Sciences of the United States of America (1999)
The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness
Nature Reviews Neuroscience (2007)
Common genetic variants on 5p14.1 associate with autism spectrum disorders
Kai Wang;Haitao Zhang;Deqiong Ma;Maja Bucan.
Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area
Carol F. Elias;Clifford B. Saper;Eleftheria Maratos-Flier;Nicholas A. Tritos.
The Journal of Comparative Neurology (1998)
Hypothalamic orexin neurons regulate arousal according to energy balance in mice.
Akihiro Yamanaka;Carsten T. Beuckmann;Jon T. Willie;Junko Hara.
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