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Neuroscience

D-Index
64
Citations
15638
World Ranking
3249
National Ranking
1508

Overview

Kumar Sambamurti is affiliated with the Medical University of South Carolina in the United States. Their research primarily spans the fields of Medicine, Biochemistry, Genetics and Molecular Biology, and Neuroscience. They have contributed notably to several subfields such as Molecular Biology, Physiology, Biological Psychiatry, Neurology, and Cellular and Molecular Neuroscience.

The scientist's research topics cover a broad range related to brain health and disease mechanisms. These include:

  • Alzheimer's disease research and treatments
  • Tryptophan and brain disorders
  • Gut microbiota and health
  • Diet and metabolism studies
  • MicroRNA in disease regulation
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Diabetes Treatment and Management

Recent papers authored or co-authored by Kumar Sambamurti demonstrate a focus on neurodegenerative diseases, immune system interactions, and molecular pathways relevant to Alzheimer's disease. Notable publications include:

  • The role of the adaptive immune system and T cell dysfunction in neurodegenerative diseases (2022, Journal of Neuroinflammation)
  • Indoles as essential mediators in the gut-brain axis. Their role in Alzheimer's disease (2021, Neurobiology of Disease)
  • Rivastigmine modifies the α-secretase pathway and potentially early Alzheimer's disease (2020, Translational Psychiatry)
  • Mechanistic Insights Into Gut Microbiome Dysbiosis-Mediated Neuroimmune Dysregulation and Protein Misfolding and Clearance in the Pathogenesis of Chronic Neurodegenerative Disorders (2022, Frontiers in Neuroscience)
  • Sex-Specific Regulation of β-Secretase: A Novel Estrogen Response Element (ERE)-Dependent Mechanism in Alzheimer's Disease (2021, Journal of Neuroscience)

Kumar Sambamurti has frequently collaborated with several researchers, including Miguel A. Pappolla, Nigel H. Greig, Debomoy K. Lahiri, Burkhard Pöeggeler, and Bryan Maloney. These collaborations have contributed to an extensive publication record within journals that include:

  • Alzheimer s & Dementia
  • International Journal of Molecular Sciences
  • Translational Psychiatry
  • Journal of Alzheimer s Disease
  • Preprints.org

Best Publications

  • Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model.

    Lorenzo M. Refolo;Miguel A. Pappolla;Brian Malester;John LaFrancois

  • Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer β-amyloid peptide in rodent

    Nigel H. Greig;Tadanobu Utsuki;Tadanobu Utsuki;Donald K. Ingram;Yue Wang

  • GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism

    Yazhou Li;Tracy Ann Perry;Mark S. Kindy;Brandon K. Harvey

  • Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.

    Ahmad Salehi;Jean Dominique Delcroix;Pavel V. Belichenko;Ke Zhan

  • Butyrylcholinesterase: an important new target in Alzheimer's disease therapy.

    Nigel H. Greig;Debomoy K. Lahiri;Kumar Sambamurti

  • Glucagon-like peptide-1 decreases endogenous amyloid-β peptide (Aβ) levels and protects hippocampal neurons from death induced by Aβ and iron

    Tracy Ann Perry;Debomoy K. Lahiri;Kumar Sambamurti;Demao Chen

  • High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice.

    Lakshmi Thirumangalakudi;Annamalai Prakasam;Ran Zhang;Heather Bimonte-Nelson

  • GLP-1 Receptor Stimulation Reduces Amyloid-β Peptide Accumulation and Cytotoxicity in Cellular and Animal Models of Alzheimer's Disease

    Yazhou Li;Kara B. Duffy;Mary Ann Ottinger;Balmiki Ray

  • Amyloid-β peptide levels in brain are inversely correlated with insulysin activity levels in vivo

    Bonnie C. Miller;Elizabeth A. Eckman;Kumar Sambamurti;Kumar Sambamurti;Nicole Dobbs

  • Amyloid-Beta Protein Clearance and Degradation (ABCD) Pathways and their Role in Alzheimer's Disease

    Robert J. Baranello;Krishna L. Bharani;Vasudevaraju Padmaraju;Nipun Chopra

  • Effects of a Saturated Fat and High Cholesterol Diet on Memory and Hippocampal Morphology in the Middle-Aged Rat

    Ann-Charlotte Granholm;Heather A. Bimonte-Nelson;Alfred B. Moore;Matthew E. Nelson

  • Resolution of inflammation is altered in Alzheimer's disease

    Xiuzhe Wang;Mingqin Zhu;Erik Hjorth;Veronica Cortés-Toro

  • Alzheimer's Disease β-Amyloid Peptide Is Increased in Mice Deficient in Endothelin-converting Enzyme

    Elizabeth A. Eckman;Mona Watson;Laura Marlow;Kumar Sambamurti

  • Differential Expression of Cholesterol Hydroxylases in Alzheimer's Disease*

    James Brown;Catherine Theisler;Simone Silberman;Debra Magnuson

  • Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells.

    John P. Anderson;Fred S. Esch;Pamela S. Keim;Kumar Sambamurti

  • Current drug targets for Alzheimer's disease treatment

    Debomoy K. Lahiri;Martin R. Farlow;Nigel H. Greig;Kumar Sambamurti

  • Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer’s disease

    Kumar Sambamurti;Nigel H. Greig;Debomoy K. Lahiri

  • Human retinal pigment epithelium cells as functional models for the RPE in vivo.

    Zsolt Ablonczy;Mohammad Dahrouj;Peter H. Tang;Yueying Liu

  • Phenserine regulates translation of β-amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development

    Karen T. Y. Shaw;Tadanobu Utsuki;Jack Rogers;Qian-Sheng Yu

  • TNF-alpha inhibition as a treatment strategy for neurodegenerative disorders: new drug candidates and targets.

    David Tweedie;Kumar Sambamurti;Nigel H. Greig

  • A critical analysis of new molecular targets and strategies for drug developments in Alzheimer's disease.

    Debomoy K. Lahiri;Martin R. Farlow;Kumar Sambamurti;Nigel H. Greig

Frequent Co-Authors

Miguel A. Pappolla
Miguel A. Pappolla The University of Texas Medical Branch at Galveston
Martin R. Farlow
Martin R. Farlow Indiana University
Narayan R. Bhat
Narayan R. Bhat Medical University of South Carolina
Mark P. Mattson
Mark P. Mattson Johns Hopkins University
Todd E. Golde
Todd E. Golde Emory University
Ahmad Salehi
Ahmad Salehi Stanford University
Karen Duff
Karen Duff University College London
Bruce T. Lamb
Bruce T. Lamb Indiana University
William C. Mobley
William C. Mobley University of California, San Diego
Shaul Schreiber
Shaul Schreiber Tel Aviv Sourasky Medical Center

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