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Molecular Biology

D-Index
76
Citations
37686
World Ranking
1129
National Ranking
585

Research.com Recognitions

  • 2015 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Arthur M. Lesk is affiliated with Pennsylvania State University in the United States. Their research spans the broad field of Biochemistry, Genetics and Molecular Biology, with a primary focus on Molecular Biology within this discipline.

The main topics of their work include:

  • Protein Structure and Dynamics
  • RNA and protein synthesis mechanisms
  • Genomics and Phylogenetic Studies
  • Enzyme Structure and Function
  • Machine Learning in Bioinformatics
  • Bioinformatics and Genomic Networks
  • Gene Regulatory Network Analysis

Frequent co-authors in Arthur M. Lesk's collaborations are:

  • Arun S. Konagurthu
  • Lloyd Allison
  • Peter J. Stuckey
  • María García de la Banda
  • David Abramson

The venues where they often publish include:

  • Frontiers in Molecular Biosciences
  • Bioinformatics
  • Proteins Structure Function and Bioinformatics
  • Journal of Biological Chemistry
  • Current Opinion in Structural Biology

Some recent publications by Arthur M. Lesk and collaborators are:

  • "Invisible leashes: The tethering VAPs from infectious diseases to neurodegeneration," 2021, Journal of Biological Chemistry
  • "On the reliability and the limits of inference of amino acid sequence alignments," 2022, Bioinformatics
  • "Universal Architectural Concepts Underlying Protein Folding Patterns," 2021, Frontiers in Molecular Biosciences
  • "Sequence and structure alignments in post-AlphaFold era," 2023, Current Opinion in Structural Biology
  • "Protein structure prediction improves the quality of amino-acid sequence alignment," 2022, Proteins Structure Function and Bioinformatics

Arthur M. Lesk has also published a book titled Protein Science with Oxford University Press in 2021.

In 2015, they were recognized as a Fellow of the American Association for the Advancement of Science (AAAS).

Best Publications

  • Canonical structures for the hypervariable regions of immunoglobulins

    Cyrus Chothia;Arthur M. Lesk;Arthur M. Lesk;Arthur M. Lesk

  • The relation between the divergence of sequence and structure in proteins.

    C. Chothia;A.M. Lesk

  • Computational molecular biology

    A. Lesk

  • Conformations of immunoglobulin hypervariable regions.

    Cyrus Chothia;Cyrus Chothia;Arthur M. Lesk;Anna Tramontano;Michael Levitt;Michael Levitt

  • Evolutionary and biomedical insights from the rhesus macaque genome

    Richard A. Gibbs;Jeffrey Rogers

  • Prediction of protein function from protein sequence and structure.

    James C. Whisstock;Arthur M. Lesk

  • Interior and surface of monomeric proteins.

    Susan Miller;Joël Janin;Arthur M. Lesk;Arthur M. Lesk;Arthur M. Lesk;Cyrus Chothia;Cyrus Chothia

  • STANDARD CONFORMATIONS FOR THE CANONICAL STRUCTURES OF IMMUNOGLOBULINS

    Bissan Al-Lazikani;Arthur M Lesk;Cyrus Chothia

  • How different amino acid sequences determine similar protein structures: the structure and evolutionary dynamics of the globins.

    Arthur M. Lesk;Cyrus Chothia

  • The outline structure of the T-cell alpha beta receptor.

    C. Chothia;D. R. Boswell;A. M. Lesk

  • Structural mechanisms for domain movements in proteins.

    Mark Gerstein;Arthur M. Lesk;Cyrus Chothia;Cyrus Chothia

  • Amyloid fibers are water-filled nanotubes

    M. F. Perutz;J. T. Finch;J. Berriman;A. Lesk

  • Phylogeny of the Serpin Superfamily: Implications of Patterns of Amino Acid Conservation for Structure and Function

    James A. Irving;Robert N. Pike;Arthur M. Lesk;James C. Whisstock

  • Structural repertoire of the human VH segments.

    Cyrus Chothia;Arthur M. Lesk;Ermanno Gherardi;Ian M. Tomlinson

  • Determinants of a protein fold. Unique features of the globin amino acid sequences.

    Donald Bashford;Cyrus Chothia;Cyrus Chothia;Arthur M. Lesk;Arthur M. Lesk

  • Introduction to bioinformatics

    Arthur M. Lesk

  • β-Trefoil fold. Patterns of structure and sequence in the Kunitz inhibitors interleukins-1β and 1α and fibroblast growth factors

    Alexey G. Murzin;Arthur M. Lesk;Cyrus Chothia

  • Sequencing the nuclear genome of the extinct woolly mammoth

    Webb Miller;Daniela I. Drautz;Aakrosh Ratan;Barbara Pusey

  • The accessible surface area and stability of oligomeric proteins

    Susan Miller;Arthur M. Lesk;Joël Janin;Cyrus Chothia;Cyrus Chothia

  • Conformations of the third hypervariable region in the VH domain of immunoglobulins

    Veronica Morea;Anna Tramontano;Mauro Rustici;Cyrus Chothia

Frequent Co-Authors

Cyrus Chothia
Cyrus Chothia MRC Laboratory of Molecular Biology
James C. Whisstock
James C. Whisstock Monash University
Peter J. Stuckey
Peter J. Stuckey Monash University
David Abramson
David Abramson University of Queensland
Anna Tramontano
Anna Tramontano Sapienza University of Rome
Annalisa Pastore
Annalisa Pastore King's College London
Webb Miller
Webb Miller Pennsylvania State University
Robin W. Carrell
Robin W. Carrell University of Cambridge
Stephan C. Schuster
Stephan C. Schuster Nanyang Technological University
David Haussler
David Haussler University of California, Santa Cruz

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