T. Michael Redmond

Best Publications

• Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis

  Albert M. Maguire;Francesca Simonelli;Eric A. Pierce;Edward N. Pugh

  2593
  Citations

• Rpe65 is necessary for production of 11- cis-vitamin A in the retinal visual cycle

  T. Michael Redmond;Shirley Yu;Eric Lee;Dean Bok

  1095
  Citations

• Age-dependent effects of RPE65 gene therapy for Leber's congenital amaurosis: a phase 1 dose-escalation trial

  Albert M. Maguire;Albert M. Maguire;Katherine A. High;Katherine A. High;Alberto Auricchio;J. Fraser Wright;J. Fraser Wright

  1018
  Citations

• Gene therapy for Leber's congenital amaurosis is safe and effective through 1.5 years after vector administration.

  Francesca Simonelli;Albert M Maguire;Albert M Maguire;Francesco Testa;Eric A Pierce

  699
  Citations

• Mutations in RPE65 cause Leber's congenital amaurosis

  Marlhens F;Bareil C;Griffoin Jm;Zrenner E

  694
  Citations

• Mutation of key residues of RPE65 abolishes its enzymatic role as isomerohydrolase in the visual cycle

  T. Michael Redmond;Eugenia Poliakov;Shirley Yu;Jen-Yue Tsai

  457
  Citations

• Molecular cloning and expression of RPE65, a novel retinal pigment epithelium-specific microsomal protein that is post-transcriptionally regulated in vitro.

  C P Hamel;E Tsilou;B A Pfeffer;J J Hooks

  409
  Citations

• Identification, Expression, and Substrate Specificity of a Mammalian β-Carotene 15,15′-Dioxygenase

  T. Michael Redmond;Susan Gentleman;Todd Duncan;Shirley Yu

  363
  Citations

• Protection of Rpe65 -deficient mice identifies rhodopsin as a mediator of light-induced retinal degeneration

  C Grimm;A Wenzel;F Hafezi;S Yu

  355
  Citations

• Functional and structural recovery of the retina after gene therapy in the RPE65 null mutation dog.

  Kristina Narfström;Martin L Katz;Ragnheidur Bragadottir;Mathias Seeliger

  299
  Citations

• New views on RPE65 deficiency: the rod system is the source of vision in a mouse model of Leber congenital amaurosis.

  Mathias W. Seeliger;Christian Grimm;Fredrik Ståhlberg;Fredrik Ståhlberg;Christoph Friedburg

  258
  Citations

• In Utero Gene Therapy Rescues Vision in a Murine Model of Congenital Blindness

  Nadine S Dejneka;Enrico M Surace;Tomas S Aleman;Artur V Cideciyan

  237
  Citations

• Spontaneous activity of opsin apoprotein is a cause of Leber congenital amaurosis.

  Michael L Woodruff;Zhongyan Wang;Hae Yun Chung;T Michael Redmond

  219
  Citations

• Spectral Domain Optical Coherence Tomography in Mouse Models of Retinal Degeneration

  Gesine Huber;Susanne C. Beck;Christian Grimm;Ayse Sahaboglu-Tekgoz

  215
  Citations

• Cone opsin mislocalization in Rpe65-/- mice: a defect that can be corrected by 11-cis retinal.

  Baerbel Rohrer;Heather R. Lohr;Peter Humphries;T. Michael Redmond

  192
  Citations

• Effect of Rpe65 knockout on accumulation of lipofuscin fluorophores in the retinal pigment epithelium.

  Martin L. Katz;T. Michael Redmond

  169
  Citations

• A QTL on distal Chromosome 3 that influences the severity of light-induced damage to mouse photoreceptors

  Michael Danciger;Michael T. Matthes;Douglas Yasamura;Novrouz B. Akhmedov

  168
  Citations

• Isolation and characterization of monkey interphotoreceptor retinoid-binding protein, a unique extracellular matrix component of the retina

  T. M. Redmond;B. Wiggert;F. A. Robey;Nga Yen Nguyen

  165
  Citations

• Retinyl esters are the substrate for isomerohydrolase.

  Gennadiy Moiseyev;Rosalie K. Crouch;Patrice Goletz;John Oatis

  164
  Citations

• RPE65 is an iron(II)-dependent isomerohydrolase in the retinoid visual cycle.

  Gennadiy Moiseyev;Yusuke Takahashi;Ying Chen;S. Gentleman

  158
  Citations