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Chemistry

D-Index
107
Citations
38143
World Ranking
921
National Ranking
367

Research.com Recognitions

  • 2020 - Fellow of the American Chemical Society
  • 2015 - Ryoji Noyori Prize, Society of Synthetic Organic Chemistry
  • 2008 - Tetrahedron Prize for Creativity in Organic Chemistry or Bioorganic and Medicinal Chemistry, Elsevier
  • 2003 - Arthur C. Cope Award, American Chemical Society (ACS)
  • 1999 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1997 - Centenary Prize, Royal Society of Chemistry (UK)
  • 1996 - Member of the National Academy of Sciences
  • 1996 - Fellow of the American Academy of Arts and Sciences
  • 1993 - Fellow of John Simon Guggenheim Memorial Foundation
  • 1975 - Fellow of Alfred P. Sloan Foundation

Overview

Larry E. Overman is a researcher affiliated with the University of California, Irvine in the United States. Their work spans multiple fields, primarily focusing on chemistry, medicine, and materials science. Within these broader areas, Overman's research concentrates on the subfields of organic chemistry, materials chemistry, pharmacology, biotechnology, and dermatology.

The main topics addressed in Overman's body of work include:

  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography
  • Radical Photochemical Reactions
  • Catalytic C-H Functionalization Methods
  • Marine Sponges and Natural Products
  • Microbial Natural Products and Biosynthesis
  • Alkaloids: synthesis and pharmacology

Significant publication venues where Overman has contributed include:

  • The Cambridge Structural Database
  • Organic Letters
  • Cancers
  • Chemical Reviews
  • Angewandte Chemie International Edition

The frequent collaborators in Overman's research are:

  • Tyler K. Allred
  • André P. Dieskau
  • Gregory L. Lackner
  • Spencer P. Pitre
  • Peng Zhao

Selected recent papers authored or co-authored by Overman include:

  • Strategic Use of Visible-Light Photoredox Catalysis in Natural Product Synthesis, 2021, Chemical Reviews
  • Lewis Acid Activation of Fragment-Coupling Reactions of Tertiary Carbon Radicals Promoted by Visible-Light Irradiation of EDA Complexes, 2021, Organic Letters
  • Enantioselective Total Synthesis of Macfarlandin C, a Spongian Diterpenoid Harboring a Concave-Substituted cis-Dioxabicyclo[3.3.0]octanone Fragment, 2020, Angewandte Chemie International Edition
  • General Access to Concave-Substituted cis-Dioxabicyclo[3.3.0]octanones: Enantioselective Total Syntheses of Macfarlandin C and Dendrillolide A, 2020, The Journal of Organic Chemistry
  • Constructing Saturated Guanidinum Heterocycles by Cycloaddition of N-Amidinyliminium Ions with Indoles, 2021, Organic Letters

Overman's research profile includes recognition through several awards and honors, among them:

  • Fellow of the American Chemical Society (2020)
  • Ryoji Noyori Prize, Society of Synthetic Organic Chemistry (2015)
  • Tetrahedron Prize for Creativity in Organic Chemistry or Bioorganic and Medicinal Chemistry, Elsevier (2008)
  • Arthur C. Cope Award, American Chemical Society (ACS) (2003)
  • Fellow of the American Association for the Advancement of Science (AAAS) (1999)
  • Centenary Prize, Royal Society of Chemistry (UK) (1997)
  • Fellow of the American Academy of Arts and Sciences (1996)
  • Member of the National Academy of Sciences (1996)
  • Fellow of John Simon Guggenheim Memorial Foundation (1993)
  • Fellow of Alfred P. Sloan Foundation (1975)

Best Publications

  • The asymmetric intramolecular Heck reaction in natural product total synthesis.

    Amy B. Dounay;Larry E. Overman

  • Catalytic enantioselective synthesis of quaternary carbon stereocentres

    Kyle W. Quasdorf;Larry E. Overman

  • Catalytic asymmetric synthesis of all-carbon quaternary stereocenters

    Christopher J. Douglas;Larry E. Overman

  • An "artificial enzyme" combining a metal catalytic group and a hydrophobic binding cavity.

    Ronald Breslow;Larry E. Overman

  • Oxalates as Activating Groups for Alcohols in Visible Light Photoredox Catalysis: Formation of Quaternary Centers by Redox-Neutral Fragment Coupling.

    Christopher C. Nawrat;Christopher R. Jamison;Yuriy Slutskyy;David W. C. MacMillan

  • Total synthesis of complex cyclotryptamine alkaloids: stereocontrolled construction of quaternary carbon stereocenters.

    Alan Steven;Larry E. Overman

  • A general method for the synthesis of amines by the rearrangement of allylic trichloroacetimidates. 1,3 Transposition of alcohol and amine functions

    Larry E. Overman

  • Strategic Use of Visible-Light Photoredox Catalysis in Natural Product Synthesis.

    Spencer P Pitre;Larry E Overman

  • Synthetic Strategies toward Natural Products Containing Contiguous Stereogenic Quaternary Carbon Atoms.

    Martin Büschleb;Stéphane Dorich;Stephen Hanessian;Daniel Tao

  • Contiguous stereogenic quaternary carbons: A daunting challenge in natural products synthesis

    Emily A. Peterson;Larry E. Overman

  • Mercury(II)‐ and Palladium(II)‐Catalyzed [3,3]‐Sigmatropic Rearrangements [New Synthetic Methods (46)]

    Larry E. Overman

  • Intramolecular alkene arylations for rapid assembly of polycyclic systems containing quaternary centers. A new synthesis of spirooxindoles and other fused and bridged ring systems

    Matthew M. Abelman;Taeboem Oh;Larry E. Overman

  • Vinylsilane- and alkynylsilane-terminated cyclization reactions

    Todd A. Blumenkopf;Larry E. Overman

  • Direct construction of quaternary carbons from tertiary alcohols via photoredox-catalyzed fragmentation of tert-alkyl N-phthalimidoyl oxalates.

    Gregory L. Lackner;Kyle W. Quasdorf;Larry E. Overman

  • Catalytic asymmetric intramolecular aminopalladation: enantioselective synthesis of vinyl-substituted 2-oxazolidinones, 2-imidazolidinones, and 2-pyrrolidinones.

    Larry E. Overman;Travis P. Remarchuk

  • Allylic and propargylic imidic esters in organic synthesis

    Larry E. Overman

  • Catalytic asymmetric rearrangement of allylic trichloroacetimidates. A practical method for preparing allylic amines and congeners of high enantiomeric purity.

    Carolyn E. Anderson;Larry E. Overman

  • Catalytic Asymmetric Synthesis of Quaternary Carbon Centers. Exploratory Investigations of Intramolecular Heck Reactions of (E)-α,β-Unsaturated 2-Haloanilides and Analogues To Form Enantioenriched Spirocyclic Products

    Atsuyuki Ashimori;Benoit Bachand;Larry E. Overman;Daniel J. Poon

  • Thermal and mercuric ion catalyzed [3,3]-sigmatropic rearrangement of allylic trichloroacetimidates. 1,3 Transposition of alcohol and amine functions

    Larry E. Overman

  • Asymmetric synthesis of either enantiomer of opium alkaloids and morphinans. Total synthesis of (-)- and (+)-dihydrocodeinone and (-)- and (+)-morphine

    Chang Y. Hong;Noriyuki Kado;Larry E. Overman

Frequent Co-Authors

Frederick Cohen
Frederick Cohen Nurix Therapeutics
Stefan F. Kirsch
Stefan F. Kirsch University of Wuppertal
David W. C. MacMillan
David W. C. MacMillan Princeton University
Kendall N. Houk
Kendall N. Houk University of California, Los Angeles
John W. Daly
John W. Daly National Institutes of Health
Ricardo Miledi
Ricardo Miledi University of California, Irvine
Neil K. Garg
Neil K. Garg University of California, Los Angeles
John P. Wolfe
John P. Wolfe University of Michigan–Ann Arbor
Warren J. Hehre
Warren J. Hehre University of California, Irvine
Martin Oestreich
Martin Oestreich Technical University of Berlin

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