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Biology and Biochemistry

D-Index
82
Citations
24073
World Ranking
3699
National Ranking
1840

Overview

Gary J. Bassell is affiliated with Emory University in the United States. Their research focuses primarily on the intersection of genetics, molecular biology, and neuroscience, with an emphasis on understanding the molecular mechanisms underlying neurodevelopmental and neurogenetic disorders.

The scientist's work spans several fields of study:

  • Biochemistry, Genetics and Molecular Biology

Key subfields where Bassell has contributed include:

  • Molecular Biology
  • Genetics
  • Neurology
  • Cellular and Molecular Neuroscience
  • Cell Biology

The main research topics addressed in their publications cover:

  • Genetics and Neurodevelopmental Disorders
  • RNA Research and Splicing
  • Amyotrophic Lateral Sclerosis Research
  • Congenital heart defects research
  • RNA modifications and cancer
  • Neurogenetic and Muscular Disorders Research
  • Genomic variations and chromosomal abnormalities

Recent papers authored by Gary J. Bassell include:

  • A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies (2021, Nature Neuroscience)
  • FMRP promotes RNA localization to neuronal projections through interactions between its RGG domain and G-quadruplex RNA sequences (2020, eLife)
  • A native function for RAN translation and CGG repeats in regulating fragile X protein synthesis (2020, Nature Neuroscience)
  • Chimeric Peptide Species Contribute to Divergent Dipeptide Repeat Pathology in c9ALS/FTD and SCA36 (2020, Neuron)
  • FUS Recognizes G Quadruplex Structures Within Neuronal mRNAs (2020, Frontiers in Molecular Biosciences)

Frequent co-authors collaborating with Bassell are:

  • Zachary T. McEachin
  • Ryan H. Purcell
  • Victor Faúndez
  • Nisha Raj
  • Jennifer G. Mullé

Bassell's research has been published often in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Neurobiology of Disease
  • Biological Psychiatry
  • Nature Neuroscience
  • Cell Reports

Best Publications

  • Fragile X Syndrome: Loss of Local mRNA Regulation Alters Synaptic Development and Function

    Gary J. Bassell;Stephen T. Warren

  • SMNΔ7, the major product of the centromeric survival motor neuron (SMN2) gene, extends survival in mice with spinal muscular atrophy and associates with full-length SMN

    Thanh T. Le;Lan T. Pham;Matthew E.R. Butchbach;Honglai L. Zhang

  • Spatial regulation of beta-actin translation by Src-dependent phosphorylation of ZBP1.

    Stefan Huttelmaier;Stefan Huttelmaier;Daniel Zenklusen;Marcell Lederer;Jason B. Dictenberg

  • Mutations in the Profilin 1 Gene Cause Familial Amyotrophic Lateral Sclerosis

    Chi Hong Wu;Claudia Fallini;Nicola Ticozzi;Pamela J. Keagle

  • Neuronal RNA granules: movers and makers.

    Michael A. Kiebler;Gary J. Bassell

  • Plastin 3 Is a Protective Modifier of Autosomal Recessive Spinal Muscular Atrophy

    Gabriela E. Oprea;Sandra Kröber;Michelle L. McWhorter;Wilfried Rossoll

  • A Direct Role for FMRP in Activity-Dependent Dendritic mRNA Transport Links Filopodial-Spine Morphogenesis to Fragile X Syndrome

    Jason B. Dictenberg;Sharon A. Swanger;Laura N. Antar;Robert H. Singer

  • Sorting of beta-actin mRNA and protein to neurites and growth cones in culture.

    Gary J. Bassell;Honglai Zhang;Anne L. Byrd;Andrea M. Femino

  • Translocation of RNA granules in living neurons.

    Roger B. Knowles;James H. Sabry;Maryann E. Martone;Thomas J. Deerinck

  • Metabotropic Glutamate Receptor Activation Regulates Fragile X Mental Retardation Protein and Fmr1 mRNA Localization Differentially in Dendrites and at Synapses

    Laura N. Antar;Rownak Afroz;Jason B. Dictenberg;Reed C. Carroll

  • Dysregulated metabotropic glutamate receptor-dependent translation of AMPA receptor and postsynaptic density-95 mRNAs at synapses in a mouse model of fragile X syndrome

    Ravi S Muddashetty;Sofija Kelić;Christina Gross;Mei Xu

  • Neurotrophin-Induced Transport of a β-Actin mRNP Complex Increases β-Actin Levels and Stimulates Growth Cone Motility

    H.L. Zhang;T. Eom;Y. Oleynikov;S.M. Shenoy

  • Reversible Inhibition of PSD-95 mRNA Translation by miR-125a, FMRP Phosphorylation, and mGluR Signaling

    Ravi S. Muddashetty;Vijayalaxmi C. Nalavadi;Christina Gross;Xiaodi Yao

  • An essential role for β-actin mRNA localization and translation in Ca2+-dependent growth cone guidance

    Jiaqi Yao;Yukio Sasaki;Zhexing Wen;Gary J Bassell

  • Activity-Dependent Trafficking and Dynamic Localization of Zipcode Binding Protein 1 and β-Actin mRNA in Dendrites and Spines of Hippocampal Neurons

    Dhanrajan M. Tiruchinapalli;Yuri Oleynikov;Sofija Kelič;Shailesh M. Shenoy

  • Local RNA translation at the synapse and in disease.

    Liqun Liu-Yesucevitz;Gary J. Bassell;Aaron D. Gitler;Anne C. Hart

  • Active Transport of the Survival Motor Neuron Protein and the Role of Exon-7 in Cytoplasmic Localization

    Honglai L. Zhang;Feng Pan;Daewha Hong;Shailesh M. Shenoy

  • Dysregulation and restoration of translational homeostasis in fragile X syndrome.

    Joel D. Richter;Gary J. Bassell;Eric Klann

  • FMRP Phosphorylation Reveals an Immediate-Early Signaling Pathway Triggered by Group I mGluR and Mediated by PP2A

    Usha Narayanan;Vijayalaxmi Nalavadi;Mika Nakamoto;David C. Pallas

  • Extracellular stimuli specifically regulate localized levels of individual neuronal mRNAs.

    Dianna E. Willis;Erna A. van Niekerk;Yukio Sasaki;Mariano Mesngon

Frequent Co-Authors

Stephen T. Warren
Stephen T. Warren Emory University
Robert H. Singer
Robert H. Singer Albert Einstein College of Medicine
Joel D. Richter
Joel D. Richter University of Massachusetts Chan Medical School
Victor Faundez
Victor Faundez Emory University
Jeffery L. Twiss
Jeffery L. Twiss University of South Carolina
Eric Klann
Eric Klann New York University
Shannon L. Gourley
Shannon L. Gourley Emory University
Yoshio Goshima
Yoshio Goshima Yokohama City University
Michael P. Epstein
Michael P. Epstein Emory University
Arthur W. English
Arthur W. English Emory University

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