University of Washington
United States
His primary areas of investigation include Virology, Coronavirus, Viral protein, Lipid bilayer fusion and Glycoprotein. His Virology research incorporates themes from Epitope and Antibody. His research in the fields of Monoclonal antibody, Monoclonal and Neutralization overlaps with other disciplines such as Betacoronavirus.
His Viral protein research integrates issues from Protein structure and Ectodomain. His Glycoprotein research includes elements of Protein folding, HEK 293 cells, Virus, Computational biology and Binding site. His Viral entry research incorporates elements of Viral Receptor and Antigenicity.
His main research concerns Virology, Coronavirus, Glycoprotein, Antibody and Viral protein. As part of his studies on Virology, M. Alejandra Tortorici often connects relevant areas like Epitope. His Glycoprotein research integrates issues from Receptor, Sialic acid and Computational biology.
His Antibody research includes themes of Immune system and Antigen. His work deals with themes such as Congenital rubella syndrome, Viral replication, Cell biology, Protein structure and Binding site, which intersect with Viral protein. Within one scientific family, M. Alejandra Tortorici focuses on topics pertaining to Antigenicity under Ectodomain, and may sometimes address concerns connected to Viral Receptor.
Virology, Antibody, Epitope, Neutralization and Coronavirus are his primary areas of study. In his work, Computational biology is strongly intertwined with Glycoprotein, which is a subfield of Virology. In Epitope, he works on issues like Monoclonal, which are connected to Entry into host.
He performs multidisciplinary study on Coronavirus and Viral entry in his works. The concepts of his Viral entry study are interwoven with issues in Antigenicity and Ectodomain. His Ectodomain study incorporates themes from Viral Receptor and Viral protein.
M. Alejandra Tortorici mostly deals with Virology, Epitope, Antibody, Coronavirus and Neutralization. M. Alejandra Tortorici connects Virology with Furin in his research. His Epitope research is multidisciplinary, incorporating perspectives in Serology, Affinity maturation and Nucleoprotein.
His study in Antibody is interdisciplinary in nature, drawing from both HEK 293 cells and Entry into host. Among his Coronavirus studies, there is a synthesis of other scientific areas such as Antigenicity, Ectodomain, Viral entry, Viral Receptor and Viral protein. His Neutralization research includes elements of Vesicular stomatitis virus and Monoclonal antibody.
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Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein.
Alexandra C. Walls;Young Jun Park;M. Alejandra Tortorici;M. Alejandra Tortorici;Abigail Wall.
Cell (2020)
Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody.
Dora Pinto;Young Jun Park;Martina Beltramello;Alexandra C. Walls.
Nature (2020)
Deep Mutational Scanning of SARS-CoV-2 Receptor Binding Domain Reveals Constraints on Folding and ACE2 Binding.
Tyler N. Starr;Allison J. Greaney;Allison J. Greaney;Sarah K. Hilton;Sarah K. Hilton;Daniel Ellis.
Cell (2020)
Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology.
Luca Piccoli;Young Jun Park;M. Alejandra Tortorici;M. Alejandra Tortorici;Nadine Czudnochowski.
Cell (2020)
Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion
Alexandra C. Walls;Xiaoli Xiong;Young Jun Park;M. Alejandra Tortorici;M. Alejandra Tortorici.
Cell (2019)
Protocol and Reagents for Pseudotyping Lentiviral Particles with SARS-CoV-2 Spike Protein for Neutralization Assays.
Katharine H D Crawford;Katharine H D Crawford;Rachel Eguia;Adam S Dingens;Andrea N Loes.
Viruses (2020)
Tectonic conformational changes of a coronavirus spike glycoprotein promote membrane fusion
Alexandra C. Walls;M. Alejandra Tortorici;M. Alejandra Tortorici;Joost Snijder;Xiaoli Xiong.
Proceedings of the National Academy of Sciences of the United States of America (2017)
Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer
Alexandra C. Walls;M. Alejandra Tortorici;M. Alejandra Tortorici;Berend Jan Bosch;Brandon Frenz.
Nature (2016)
Structural basis for human coronavirus attachment to sialic acid receptors.
M. Alejandra Tortorici;M. Alejandra Tortorici;M. Alejandra Tortorici;Alexandra C. Walls;Yifei Lang;Chunyan Wang.
Nature Structural & Molecular Biology (2019)
Structural insights into coronavirus entry
M Alejandra Tortorici;David Veesler.
Advances in Virus Research (2019)
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