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Biology and Biochemistry

D-Index
85
Citations
28499
World Ranking
3127
National Ranking
238

Overview

Jürgen Bernhagen is affiliated with Ludwig-Maximilians-Universität München in Germany and has a research focus spanning immunology, microbiology, and medicine.

Their work involves multiple subfields, including immunology, cellular and molecular neuroscience, molecular biology, oncology, and pharmacology. They have contributed extensively to topics such as macrophage migration inhibitory factor, nuclear receptors and signaling, atherosclerosis and cardiovascular diseases, galectins and cancer biology, apelin-related biomedical research, chemokine receptors and signaling, and immune cells in cancer.

Bernhagen's recent papers include the following publications:

  • Neuroimmune cardiovascular interfaces control atherosclerosis (2022, Nature)
  • Targeting the CCL2-CCR2 axis for atheroprotection (2022, European Heart Journal)
  • Histone Deacetylase 9 Activates IKK to Regulate Atherosclerotic Plaque Vulnerability (2020, Circulation Research)
  • Macrophage migration inhibitory factor exerts pro-proliferative and anti-apoptotic effects via CD74 in murine hepatocellular carcinoma (2021, British Journal of Pharmacology)
  • Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting (2020, Nature Communications)

The scientist frequently collaborates with others, with key co-authors including Martin Dichgans, Omar El Bounkari, Christian Weber, Markus Brandhofer, and Aphrodite Kapurniotu.

Bernhagen regularly publishes in several venues, notably bioRxiv (Cold Spring Harbor Laboratory), The FASEB Journal, Nature Communications, Atherosclerosis, and Cellular and Molecular Life Sciences.

Best Publications

  • MIF as a glucocorticoid-induced modulator of cytokine production

    Thierry Calandra;Jürgen Bernhagen;Christine N. Metz;Lori A. Spiegel

  • MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment

    Jürgen Bernhagen;Regina Krohn;Hongqi Lue;Julia L Gregory

  • MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia

    J. Bernhagen;T. Calandra;R. A. Mitchell;S. B. Martin

  • Investigations on DNA intercalation and surface binding by SYBR Green I, its structure determination and methodological implications

    Hubert Zipper;Herwig Brunner;Jürgen Bernhagen;Frank Vitzthum

  • Cytokines in Sepsis: Potent Immunoregulators and Potential Therapeutic Targets—An Updated View

    Wibke Schulte;Jürgen Bernhagen;Richard Bucala

  • Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1

    Robert Kleemann;Angelika Hausser;Georg Geiger;Ralf Mischke

  • An agent cleaving glucose-derived protein crosslinks in vitro and in vivo

    Vasan S;Zhang X;Kapurniotu A;Bernhagen J

  • Purification, bioactivity, and secondary structure analysis of mouse and human macrophage migration inhibitory factor (MIF).

    Jurgen Bernhagen;Robert A. Mitchell;Thierry Calandra;Wolfgang Voelter

  • Crystal structure at 2.6-A resolution of human macrophage migration inhibitory factor.

    Hong-Wei Sun;Jurgen Bernhagen;Richard Bucala;Elias Lolis

  • Identification of a penta- and hexapeptide of islet amyloid polypeptide (IAPP) with amyloidogenic and cytotoxic properties.

    Konstantinos Tenidis;Michaela Waldner;Jürgen Bernhagen;Wolfgang Fischle

  • Macrophage migration inhibitory factor (MIF): mechanisms of action and role in disease.

    Hongqi Lue;Robert Kleemann;Thierry Calandra;Thierry Roger

  • Macrophage migration inhibitory factor (MIF) promotes cell survival by activation of the akt pathway and role for CSN5/JAB1 in the control of autocrine MIF activity

    H Lue;M Thiele;J Franz;E Dahl

  • MIF: a new cytokine link between rheumatoid arthritis and atherosclerosis

    Eric Francis Morand;Michelle Theresa Leech;Jurgen Bernhagen

  • Conformational transitions of islet amyloid polypeptide (IAPP) in amyloid formation in Vitro

    Rakez Kayed;Jürgen Bernhagen;Norma Greenfield;Khuloud Sweimeh

  • Expression of Macrophage Migration Inhibitory Factor in Different Stages of Human Atherosclerosis

    Anke Burger-Kentischer;Heike Goebel;Rüdiger Seiler;Gustav Fraedrich

  • Disulfide analysis reveals a role for macrophage migration inhibitory factor (MIF) as thiol-protein oxidoreductase

    Robert Kleemann;Aphrodite Kapurniotu;Rainer W Frank;André Gessner

  • An essential role for macrophage migration inhibitory factor in the tuberculin delayed-type hypersensitivity reaction

    Jürgen Bernhagen;Michael Bacher;Thierry Calandra;Christine N. Metz

  • Macrophage Migration Inhibitory Factor in Cardiovascular Disease

    Alma Zernecke;Jürgen Bernhagen;Christian Weber

  • The Macrophage Migration Inhibitory Factor- Glucocorticoid Dyad: Regulation of Inflammation and Immunity

    Harry Flaster;Jürgen Bernhagen;Thierry Calandra;Richard Bucala

  • Regulated secretion of macrophage migration inhibitory factor is mediated by a non‐classical pathway involving an ABC transporter

    Oliver Flieger;André Engling;Richard Bucala;Hongqi Lue

Frequent Co-Authors

Richard Bucala
Richard Bucala Yale University
Christian Weber
Christian Weber Ludwig-Maximilians-Universität München
Lin Leng
Lin Leng Yale University
Thierry Calandra
Thierry Calandra University of Lausanne
Robert Kleemann
Robert Kleemann Netherlands Organisation for Applied Scientific Research
Christian Trautwein
Christian Trautwein RWTH Aachen University
Wolfgang Voelter
Wolfgang Voelter University of Tübingen
Thierry Roger
Thierry Roger University of Lausanne
Malte Kelm
Malte Kelm Heinrich Heine University Düsseldorf
Ralph Panstruga
Ralph Panstruga RWTH Aachen University

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