His scientific interests lie mostly in Immunology, Germinal center, Antigen, Interleukin 21 and CD40. Matthew C. Cook studies Immunology, namely Naive B cell. His Germinal center study combines topics in areas such as Molecular biology, Somatic hypermutation and Autoantibody.
His Antigen research is multidisciplinary, relying on both Interleukin, Immunoglobulin E, Innate immune system and Candida albicans. His Interleukin 21 research integrates issues from Systemic lupus erythematosus, Adoptive cell transfer, Autoimmunity and BCL6. His research investigates the connection between CD40 and topics such as B cell selection that intersect with issues in Antigen-presenting cell, Affinity maturation, Follicular dendritic cells and Interleukin 4.
Matthew C. Cook mostly deals with Immunology, Immune system, Antigen, Cell biology and Antibody. His study in Cellular differentiation extends to Immunology with its themes. His Immune system research incorporates elements of Mutation, Effector and Vaccination.
In Antigen, Matthew C. Cook works on issues like CD40, which are connected to Bruton's tyrosine kinase. His study looks at the intersection of Cell biology and topics like IL-2 receptor with Interleukin 10. His studies in Interleukin 21 integrate themes in fields like Cancer research, BCL6, Interleukin 4 and CXCR5.
Matthew C. Cook mainly investigates Antigen, Whole genome sequencing, Genetics, Immunology and Missense mutation. His research integrates issues of Virology, Assay sensitivity, T cell, Antibody and Seroprevalence in his study of Antigen. Matthew C. Cook works mostly in the field of T cell, limiting it down to topics relating to Cell biology and, in certain cases, Mutation, as a part of the same area of interest.
His Whole genome sequencing study integrates concerns from other disciplines, such as Strain, Genetic variation and Sequence. In his work, Matthew C. Cook performs multidisciplinary research in Immunology and Antigen Sensitization. His Missense mutation research includes elements of Lupus erythematosus, Short read and Allele frequency.
His main research concerns Antigen, Immunology, T cell, Immune system and Mutation. The concepts of his Antigen study are interwoven with issues in Assay sensitivity, Seroepidemiologic Studies, Confidence interval and Virology. Many of his studies involve connections with topics such as Penetrance and Immunology.
His T cell study incorporates themes from Immunoglobulin E, FOXP3, Interleukin 10 and B cell. In the field of Immune system, his study on Keyhole limpet hemocyanin, Immunity and Immunization overlaps with subjects such as Antibody titer. His Mutation research integrates issues from Cell, Cell biology, Mucosal associated invariant T cell and Ligand.
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A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity
Carola G. Vinuesa;Matthew C. Cook;Constanza Angelucci;Vicki Athanasopoulos.
Extrafollicular antibody responses.
Ian C. M. MacLennan;Kai-Michael Toellner;Adam F. Cunningham;Karine Serre.
Immunological Reviews (2003)
Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus.
Nicholas Simpson;Paul A. Gatenby;Anastasia Wilson;Shreya Malik.
Arthritis & Rheumatism (2010)
Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3
Cindy S. Ma;Gary Y.J. Chew;Nicholas Simpson;Archana Priyadarshi.
Journal of Experimental Medicine (2008)
Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis.
Chad K Heazlewood;Matthew C Cook;Rajaraman Eri;Gareth R Price.
PLOS Medicine (2008)
Follicular helper T cells are required for systemic autoimmunity.
Michelle A. Linterman;Robert J. Rigby;Raphael. K. Wong;Di Yu.
Journal of Experimental Medicine (2009)
Circulating precursor CCR7(lo)PD-1(hi) CXCR5⁺ CD4⁺ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure.
Jing He;Louis M Tsai;Yew A Leong;Xin Jack Hu;Xin Jack Hu.
Updated assessment of the prevalence, spectrum and case definition of autoimmune disease.
Scott M. Hayter;Matthew C. Cook;Matthew C. Cook.
Autoimmunity Reviews (2012)
Dysregulation of germinal centres in autoimmune disease
Carola G. Vinuesa;Iñaki Sanz;Matthew C. Cook.
Nature Reviews Immunology (2009)
B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans
Danielle T. Avery;Elissa K. Deenick;Elissa K. Deenick;Cindy S. Ma;Cindy S. Ma;Santi Suryani;Santi Suryani.
Journal of Experimental Medicine (2010)
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