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Immunology

D-Index
56
Citations
15343
World Ranking
3682
National Ranking
152

Overview

Matthew C. Cook is affiliated with the Australian National University in Australia. Their research spans multiple interconnected fields within biomedical science, focusing on the mechanisms and clinical aspects of immune function and disorders.

The primary areas of study include Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology. Within these broad fields, Matthew's work concentrates on Immunology, Molecular Biology, Genetics, Pulmonary and Respiratory Medicine, and Oncology.

Their research topics cover a range of subjects related to immune responses and disease processes, such as:

  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Immunodeficiency and Autoimmune Disorders
  • Cytokine Signaling Pathways and Interactions
  • Systemic Lupus Erythematosus Research
  • NF-κB Signaling Pathways
  • Blood disorders and treatments

Matthew C. Cook has published extensively, with notable recent papers including:

  • "TLR7 gain-of-function genetic variation causes human lupus," 2022, published in Nature
  • "Automatic detection of synaptic partners in a whole-brain Drosophila electron microscopy data set," 2021, published in Nature Methods
  • "Characterization of the clinical and immunologic phenotype and management of 157 individuals with 56 distinct heterozygous NFKB1 mutations," 2020, published in the Journal of Allergy and Clinical Immunology
  • "Monogenic early-onset lymphoproliferation and autoimmunity: Natural history of STAT3 gain-of-function syndrome," 2022, published in the Journal of Allergy and Clinical Immunology
  • "Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in MR1," 2020, published in Science Immunology

The frequent publication venues for Matthew's work are diverse, reflecting both preprint and peer-reviewed outlets, including:

  • arXiv (Cornell University)
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Immunology
  • Journal of Allergy and Clinical Immunology
  • The Journal of Experimental Medicine

Collaborations are a significant aspect of Matthew's research, with frequent co-authors including Carola G. Vinuesa, Vicki Athanasopoulos, Jane Desborough, Anne Parkinson, and Christine Phillips. These partnerships indicate ongoing contributions to complex, multidisciplinary projects in immunology and related biomedical fields.

Best Publications

  • A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity

    Carola G. Vinuesa;Matthew C. Cook;Constanza Angelucci;Vicki Athanasopoulos

  • Extrafollicular antibody responses.

    Ian C. M. MacLennan;Kai-Michael Toellner;Adam F. Cunningham;Karine Serre

  • Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis.

    Chad K Heazlewood;Matthew C Cook;Rajaraman Eri;Gareth R Price

  • Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus.

    Nicholas Simpson;Paul A. Gatenby;Anastasia Wilson;Shreya Malik

  • Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3

    Cindy S. Ma;Gary Y.J. Chew;Nicholas Simpson;Archana Priyadarshi

  • Circulating precursor CCR7(lo)PD-1(hi) CXCR5⁺ CD4⁺ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure.

    Jing He;Louis M Tsai;Yew A Leong;Xin Jack Hu;Xin Jack Hu

  • TLR7 gain-of-function genetic variation causes human lupus

    Unknown

  • Follicular helper T cells are required for systemic autoimmunity.

    Michelle A. Linterman;Robert J. Rigby;Raphael. K. Wong;Di Yu

  • Updated assessment of the prevalence, spectrum and case definition of autoimmune disease.

    Scott M. Hayter;Matthew C. Cook;Matthew C. Cook

  • Dysregulation of germinal centres in autoimmune disease

    Carola G. Vinuesa;Iñaki Sanz;Matthew C. Cook

  • B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans

    Danielle T. Avery;Elissa K. Deenick;Elissa K. Deenick;Cindy S. Ma;Cindy S. Ma;Santi Suryani;Santi Suryani

  • Germinal Centers without T Cells

    Carola García de Vinuesa;Matthew C. Cook;Jennifer Ball;Marion Drew

  • Functional STAT3 deficiency compromises the generation of human T follicular helper cells

    Cindy S. Ma;Cindy S. Ma;Danielle T. Avery;Anna Chan;Marcel Batten;Marcel Batten

  • Distinct roles for lymphotoxin-alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue.

    Heinrich Körner;Matthew Cook;D. Sean Riminton;Frances A. Lemckert

  • Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis.

    Jesse E. Jun;Lauren E. Wilson;Carola G. Vinuesa;Sylvie Lesage

  • The fate of self-reactive B cells depends primarily on the degree of antigen receptor engagement and availability of T cell help.

    DA Fulcher;AB Lyons;SL Korn;MC Cook

  • Stress reactivity of the brain noradrenergic system in three rat strains differing in their neuroendocrine and behavioral responses to stress: implications for susceptibility to stress-related neuropsychiatric disorders.

    M.-C Pardon;G.G Gould;A Garcia;L Phillips

  • IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells

    Marcel Batten;Marcel Batten;Nandhini Ramamoorthi;Noelyn M. Kljavin;Cindy S. Ma;Cindy S. Ma

  • Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies

    Cindy S. Ma;Cindy S. Ma;Natalie Wong;Geetha Rao;Danielle T. Avery

  • Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells

    Elissa K. Deenick;Elissa K. Deenick;Danielle T. Avery;Anna Chan;Lucinda J. Berglund;Lucinda J. Berglund;Lucinda J. Berglund

  • Extrafollicular Antibody Responses

    Carola G. Vinuesa

  • Human Foxp3-negative follicular regulatory T cells control IgE responses

    Pablo Canete;Rebecca Sweet;Ilenia Papa;Paula Gonzalez-Figueroa

Frequent Co-Authors

Carola G. Vinuesa
Carola G. Vinuesa Australian National University
Stuart G. Tangye
Stuart G. Tangye Garvan Institute of Medical Research
Christopher C. Goodnow
Christopher C. Goodnow Garvan Institute of Medical Research
Cindy S. Ma
Cindy S. Ma Garvan Institute of Medical Research
Elissa K. Deenick
Elissa K. Deenick Garvan Institute of Medical Research
Martyn A. French
Martyn A. French University of Western Australia
Stéphanie Boisson-Dupuis
Stéphanie Boisson-Dupuis Université Paris Cité
Jean-Laurent Casanova
Jean-Laurent Casanova The University of Texas Southwestern Medical Center
Stephen Adelstein
Stephen Adelstein Royal Prince Alfred Hospital
Jacinta Bustamante
Jacinta Bustamante Rockefeller University

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