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Immunology

D-Index
70
Citations
13878
World Ranking
2451
National Ranking
1171

Overview

Kohtaro Fujihashi is affiliated with the University of Alabama at Birmingham in the United States. Their research spans multiple fields including Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology, reflecting an interdisciplinary approach to scientific inquiry.

Their work covers a range of subfields such as Immunology, Infectious Diseases, Biotechnology, Epidemiology, and Molecular Biology. This breadth is reflected in the topics addressed through their publications, notably in areas like Viral gastroenteritis research and epidemiology, Immune Response and Inflammation, Transgenic Plants and Applications, Escherichia coli research studies, Pneumonia and Respiratory Infections, Salivary Gland Disorders and Functions, and Immunotherapy and Immune Responses.

Fujihashi's publication record includes articles in journals with various focuses, with some frequent venues being Vaccine, Frontiers in Plant Science, Frontiers in Immunology, Cell Reports, and Expert Review of Vaccines. The number of publications in these venues underlines an emphasis on vaccine development, immunology, and applied microbiological research.

  • The gut microbiota induces Peyer's-patch-dependent secretion of maternal IgA into milk (2021, Cell Reports)
  • Oral MucoRice-CTB vaccine for safety and microbiota-dependent immunogenicity in humans: a phase 1 randomised trial (2021, The Lancet Microbe)
  • Mucosal vaccination: onward and upward (2023, Expert Review of Vaccines)
  • Nasal vaccines: solutions for respiratory infectious diseases (2022, Trends in Molecular Medicine)
  • Mucosal vaccines: wisdom from now and then (2021, International Immunology)

Their frequent co-authors include Yoshikazu Yuki, Hiroshi Kiyono, Rika Nakahashi-Ouchida, Shiho Kurokawa, and Tomoyuki Yamanoue, indicating active collaborations with researchers specializing in similar or complementary fields.

  • Yoshikazu Yuki
  • Hiroshi Kiyono
  • Rika Nakahashi-Ouchida
  • Shiho Kurokawa
  • Tomoyuki Yamanoue

This scientist's research contributions focus heavily on understanding immune responses related to mucosal vaccination and the interactions between microbiota and immune function. Their work includes clinical trials and experimental studies that explore innovative vaccine approaches targeting respiratory and gastrointestinal infections.

Best Publications

  • Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4.

    M Marinaro;H F Staats;T Hiroi;R J Jackson

  • A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota

    Yingzi Cong;Ting Feng;Kohtaro Fujihashi;Trenton R. Schoeb

  • A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity

    Shingo Yamamoto;Hiroshi Kiyono;Masafumi Yamamoto;Koichi Imaoka

  • Mutants in the ADP-ribosyltransferase Cleft of Cholera Toxin Lack Diarrheagenicity but Retain Adjuvanticity

    Shingo Yamamoto;Yoshifumi Takeda;Masafumi Yamamoto;Hisao Kurazono

  • Optimizing oral vaccines: induction of systemic and mucosal B-cell and antibody responses to tetanus toxoid by use of cholera toxin as an adjuvant.

    R. J. Jackson;K. Fujihashi;Jiangchun Xu-Amano;H. Kiyono

  • Inside the Mucosal Immune System

    Jerry R. McGhee;Kohtaro Fujihashi

  • Hapten-induced colitis is associated with colonic patch hypertrophy and T helper cell 2-type responses.

    Taeko Dohi;Kohtaro Fujihashi;Paul D. Rennert;Koichi Iwatani

  • Inflammatory mediators of the terminal dentition in adult and early onset periodontitis

    G. E. Salvi;G. E. Salvi;C. E. Brown;K. Fujihashi;H. Kiyono

  • Immunoregulatory functions for murine intraepithelial lymphocytes: gamma/delta T cell receptor-positive (TCR+) T cells abrogate oral tolerance, while alpha/beta TCR+ T cells provide B cell help.

    K Fujihashi;T Taguchi;W K Aicher;J R McGhee

  • A dilemma for mucosal vaccination: efficacy versus toxicity using enterotoxin-based adjuvants.

    Kohtaro Fujihashi;Toshiya Koga;Frederik W. van Ginkel;Yukari Hagiwara

  • Indigenous opportunistic bacteria inhabit mammalian gut-associated lymphoid tissues and share a mucosal antibody-mediated symbiosis

    Takashi Obata;Yoshiyuki Goto;Jun Kunisawa;Shintaro Sato

  • gamma/delta T cell-deficient mice have impaired mucosal immunoglobulin A responses.

    Kohtaro Fujihashi;Jerry R. McGhee;Mi-Na Kweon;Max Cooper

  • Peyer's patches are required for oral tolerance to proteins

    Kohtaro Fujihashi;Taeko Dohi;Paul D. Rennert;Masafumi Yamamoto

  • Differences in intraepithelial lymphocyte T cell subsets isolated from murine small versus large intestine.

    K W Beagley;K Fujihashi;A S Lagoo;S Lagoo-Deenadaylan

  • Mechanisms for Mucosal Immunogenicity and Adjuvancy of Escherichia coli Labile Enterotoxin

    Ichiro Takahashi;Mariarosaria Marinaro;Hiroshi Kiyono;Raymond J. Jackson

  • Nasal Immunization of Nonhuman Primates with Simian Immunodeficiency Virus p55gag and Cholera Toxin Adjuvant Induces Th1/Th2 Help for Virus-Specific Immune Responses in Reproductive Tissues

    Koichi Imaoka;Christopher J. Miller;Mitsuru Kubota;Michael B. McChesney

  • Alternate Mucosal Immune System: Organized Peyer’s Patches Are Not Required for IgA Responses in the Gastrointestinal Tract

    Masafumi Yamamoto;Masafumi Yamamoto;Paul Rennert;Jerry R. McGhee;Mi-Na Kweon

  • Novel vaccine development strategies for inducing mucosal immunity

    Fujkuyama Y;Tokuhara D;Kataoka K;Gilbert Rs

  • Nasal immunization induces Haemophilus influenzae-specific Th1 and Th2 responses with mucosal IgA and systemic IgG antibodies for protective immunity.

    Yuichi Kurono;Yuichi Kurono;Masafumi Yamamoto;Masafumi Yamamoto;Kohtaro Fujihashi;Satoru Kodama

  • Human appendix B cells naturally express receptors for and respond to interleukin 6 with selective IgA1 and IgA2 synthesis.

    K Fujihashi;J R McGhee;C Lue;K W Beagley

Frequent Co-Authors

Hiroshi Kiyono
Hiroshi Kiyono University of Tokyo
Jerry R. McGhee
Jerry R. McGhee University of Alabama at Birmingham
Kenneth W. Beagley
Kenneth W. Beagley Queensland University of Technology
Shigetada Kawabata
Shigetada Kawabata Osaka University
Mi-Na Kweon
Mi-Na Kweon University of Ulsan
David E. Briles
David E. Briles University of Alabama at Birmingham
Herman F. Staats
Herman F. Staats Duke University
Yoshikazu Yuki
Yoshikazu Yuki University of Tokyo
Christopher J. Miller
Christopher J. Miller University of California, Davis
John H. Eldridge
John H. Eldridge University of Alabama at Birmingham

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