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Immunology

D-Index
48
Citations
6944
World Ranking
4457
National Ranking
2017

Overview

David W. Pascual is affiliated with the University of Florida in the United States and has contributed extensively to the fields of immunology and microbiology. Their research spans immunology, small animal studies, molecular biology, epidemiology, and infectious diseases, with a particular focus on immune responses and pathogen interactions.

The scientist's work covers a variety of main topics, including:

  • Brucella: diagnosis, epidemiology, treatment
  • Immunotherapy and Immune Responses
  • T-cell and B-cell Immunology
  • Burkholderia infections and melioidosis
  • Immune Cell Function and Interaction
  • Galectins and Cancer Biology
  • Extracellular vesicles in disease

David W. Pascual has been involved in producing several papers, some of the recent ones include:

  • Antigen-encapsulating host extracellular vesicles derived from Salmonella-infected cells stimulate pathogen-specific Th1-type responses in vivo, 2021, published in PLoS Pathogens
  • Targeting resident memory T cell immunity culminates in pulmonary and systemic protection against Brucella infection, 2020, published in PLoS Pathogens
  • Extracellular vesicles elicit protective immune responses against Salmonella infection, 2022, published in Journal of Extracellular Vesicles
  • Activation of mucosal immunity as a novel therapeutic strategy for combating brucellosis, 2022, published in Frontiers in Microbiology
  • Oral therapy with colonization factor antigen I prevents development of type 1 diabetes in Non-obese Diabetic mice, 2020, published in Scientific Reports

Frequent collaborators include:

  • Carol Hoffman
  • Xinghong Yang
  • Zakia I. Goodwin
  • Ali Akgül
  • Ella Bhagyaraj

Their research has been disseminated across various publication venues. Notable among these are:

  • The Journal of Immunology
  • PLoS Pathogens
  • Scientific Reports
  • Frontiers in Immunology
  • American Journal of Veterinary Research

In addition to journal articles, David W. Pascual has been involved in book publications, including a title published by Academic Press:

  • Mucosal vaccines: innovation for preventing infectious diseases, published in 2020

The collective output reflects a multidisciplinary approach integrating immunology, microbiology, and translational medical research to study infectious diseases and immune mechanisms, particularly focusing on pathogens like Brucella and Salmonella and the development of immune-based therapies and vaccines.

Best Publications

  • Regulation of mucosal and systemic antibody responses by T helper cell subsets, macrophages, and derived cytokines following oral immunization with live recombinant Salmonella.

    J L VanCott;H F Staats;D W Pascual;M Roberts

  • IL-35 Stimulation of CD39+ Regulatory T Cells Confers Protection against Collagen II-Induced Arthritis via the Production of IL-10

    Irina Kochetkova;Sarah Golden;Kathryn Holderness;Gayle Callis

  • Regulation of host immune responses by modification of Salmonella virulence genes.

    John L. VanCott;Stephen N. Chatfield;Mark Roberts;David M. Hone

  • Modulation of the mRNAs encoding substance P and its receptor in rat macrophages by LPS.

    K. L. Bost;S. A. L. Breeding;D. W. Pascual

  • Substance P production by P388D1 macrophages: a possible autocrine function for this neuropeptide.

    D W Pascual;K L Bost

  • Progress in Brucella vaccine development

    Xinghong Yang;Jerod A. Skyberg;Ling Cao;Beata Clapp

  • M cell-targeted DNA vaccination

    Yunpeng Wu;Xinhai Wang;Keri L. Csencsits;Asmahan Haddad

  • Nasal-Associated Lymphoid Tissue: Phenotypic and Functional Evidence for the Primary Role of Peripheral Node Addressin in Naive Lymphocyte Adhesion to High Endothelial Venules in a Mucosal Site

    Keri L. Csencsits;Mark A. Jutila;David W. Pascual

  • Intratracheal Gene Delivery with Adenoviral Vector Induces Elevated Systemic IgG and Mucosal IgA Antibodies to Adenovirus and β-Galactosidase

    Frederik W. van Ginkel;Chongguang Liu;Jerry W. Simecka;Jian-Yun Dong

  • Antibodies against a peptide sequence within the HIV envelope protein crossreacts with human interleukin-2.

    Kenneth L. Bost;David W. Pascual

  • Systematic analysis of repeated gene delivery into animal lungs with a recombinant adenovirus vector.

    Jian-Yun Dong;Danher Wang;Frederik W. van Ginkel;David W. Pascual

  • Deletion of znuA virulence factor attenuates Brucella abortus and confers protection against wild-type challenge.

    Xinghong Yang;Todd Becker;Nancy Walters;David W. Pascual

  • Substance P acts directly upon cloned B lymphoma cells to enhance IgA and IgM production.

    D. W. Pascual;Jiangchun Xu-Amano;H. Kiyono;J. R. Mcghee

  • Substance P: a late-acting B lymphocyte differentiation cofactor.

    K. L. Bost;D. W. Pascual

  • Interleukin-35 Inhibits Endothelial Cell Activation by Suppressing MAPK-AP-1 Pathway

    Xiaojin Sha;Shu Meng;Xinyuan Li;Hang Xi

  • Cannabinoid agonist WIN 55,212-2 prevents the development of paclitaxel-induced peripheral neuropathy in rats. Possible involvement of spinal glial cells.

    Elisa Burgos;Diego Gómez-Nicola;David Pascual;María Isabel Martín

  • Oral Immunization with a Salmonella typhimurium Vaccine Vector Expressing Recombinant Enterotoxigenic Escherichia coli K99 Fimbriae Elicits Elevated Antibody Titers for Protective Immunity

    Miguel A. Ascón;David M. Hone;Nancy Walters;David W. Pascual

  • Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors.

    Igor A. Schepetkin;Liliya N. Kirpotina;Andrei I. Khlebnikov;Tracey S. Hanks

  • Selection of Protective Epitopes for Brucella melitensis by DNA Vaccination

    Xinghong Yang;Mary Hudson;Nancy Walters;Robert F. Bargatze

  • Expression of recombinant enterotoxigenic Escherichia coli colonization factor antigen I by Salmonella typhimurium elicits a biphasic T helper cell response

    David W. Pascual;David M. Hone;Stacy Hall;Frederik W. van Ginkel

Frequent Co-Authors

Hiroshi Kiyono
Hiroshi Kiyono University of Tokyo
Kenneth L. Bost
Kenneth L. Bost University of North Carolina at Charlotte
Jerry R. McGhee
Jerry R. McGhee University of Alabama at Birmingham
Mark A. Jutila
Mark A. Jutila Montana State University
Herman F. Staats
Herman F. Staats Duke University
Kohtaro Fujihashi
Kohtaro Fujihashi University of Alabama at Birmingham
Soman N. Abraham
Soman N. Abraham Duke University
Sallie R. Permar
Sallie R. Permar Duke University
Shunji Kozaki
Shunji Kozaki Osaka Metropolitan University
Suzanne Oparil
Suzanne Oparil University of Alabama at Birmingham

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