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D-Index
36
Citations
5259
World Ranking
9006
National Ranking
529

Overview

Alan S. Hazell is a researcher affiliated with the University of Montreal in Canada. Their academic work spans multiple fields within medicine, primarily focusing on neurology, endocrinology, diabetes and metabolism, developmental neuroscience, and infectious diseases.

Their research topics prominently include:

  • Alcoholism and Thiamine Deficiency
  • Neurological and metabolic disorders
  • Neurogenesis and neuroplasticity mechanisms
  • Infectious Encephalopathies and Encephalitis

Hazell has contributed to the scientific community through publications in venues such as Neurochemical Research and Metabolic Brain Disease. These publications reflect their focus on brain health, metabolism, and neurological conditions.

Recent notable papers include:

  • Region-selective permeability of the blood-brain barrier to α-aminoisobutyric acid during thiamine deficiency and following its reversal, 2020, Metabolic Brain Disease
  • Stem Cell Therapy and Thiamine Deficiency-Induced Brain Damage, 2024, Neurochemical Research

Their collaborations include work with frequent coauthors such as Roger F. Butterworth, contributing jointly to advancing the understanding of thiamine deficiency and related neurological impacts.

Alan S. Hazell's work is situated within the broader context of medicine, with a particular concentration on the mechanisms underlying brain disorders associated with nutritional deficiencies and metabolic dysfunctions. Their research addresses both clinical and experimental questions related to neurochemical changes, brain barrier permeability, and therapeutic approaches, including stem cell therapy.

This multidisciplinary focus integrates concepts from neurology, metabolism, and infectious disease research, highlighting intersections between brain function, systemic metabolic conditions, and regenerative medicine.

Best Publications

  • Excitotoxic mechanisms and the role of astrocytic glutamate transporters in traumatic brain injury

    Jae-Hyuk Yi;Alan S. Hazell

  • Hepatic encephalopathy: An update of pathophysiologic mechanisms.

    Alan S. Hazell;Roger F. Butterworth

  • Excitotoxic mechanisms in stroke: an update of concepts and treatment strategies.

    Alan S. Hazell

  • Manganese neurotoxicity: an update of pathophysiologic mechanisms.

    Louise Normandin;Alan S Hazell

  • Update of Cell Damage Mechanisms in Thiamine Deficiency: Focus on Oxidative Stress, Excitotoxicity and Inflammation

    Alan S Hazell;Roger F Butterworth

  • Mechanisms of Neuronal Cell Death in Wernicke's Encephalopathy

    Alan S. Hazell;Kathryn G. Todd;Roger F. Butterworth

  • Energy metabolism in astrocytes and neurons treated with manganese: relation among cell-specific energy failure, glucose metabolism, and intercellular trafficking using multinuclear NMR-spectroscopic analysis.

    Claudia Zwingmann;Claudia Zwingmann;Dieter Leibfritz;Alan S Hazell

  • Astrocytes and manganese neurotoxicity.

    Alan S Hazell

  • Thiamine deficiency: an update of pathophysiologic mechanisms and future therapeutic considerations.

    Eman Abdou;Alan S. Hazell

  • Cerebral Vulnerability Is Associated with Selective Increase in Extracellular Glutamate Concentration in Experimental Thiamine Deficiency

    Alan S. Hazell;Roger F. Butterworth;Antoine M. Hakim

  • Effects of ammonia on glutamate transporter (GLAST) protein and mRNA in cultured rat cortical astrocytes

    Helen Chan;Alan S Hazell;Paul Desjardins;Roger F Butterworth

  • Manganese Decreases Glutamate Uptake in Cultured Astrocytes

    Alan S. Hazell;Michael D. Norenberg;Michael D. Norenberg

  • Astrocytes are a major target in thiamine deficiency and Wernicke's encephalopathy

    Alan S. Hazell

  • Modeling neurodegenerative disease pathophysiology in thiamine deficiency: consequences of impaired oxidative metabolism.

    Shivraj S. Jhala;Alan S. Hazell

  • Selective down-regulation of the astrocyte glutamate transporters GLT-1 and GLAST within the medial thalamus in experimental Wernicke's encephalopathy.

    Alan S. Hazell;K. V. Rama Rao;Niels C. Danbolt;David V. Pow

  • Immunohistochemical detection of inducible nitric oxide synthase, nitrotyrosine and manganese superoxide dismutase following hyperglycemic focal cerebral ischemia.

    Line Ste-Marie;Alan S Hazell;Chantal Bémeur;Roger Butterworth

  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) decreases glutamate uptake in cultured astrocytes

    Alan S. Hazell;Yossef Itzhak;Huaping Liu;Michael D. Norenberg;Michael D. Norenberg

  • Induction of astrocytic cyclooxygenase-2 in epileptic patients with hippocampal sclerosis.

    Paul Desjardins;Anny Sauvageau;Alain Bouthillier;Darren Navarro

  • Alzheimer type II astrocytic changes following sub-acute exposure to manganese and its prevention by antioxidant treatment.

    Alan S. Hazell;Louise Normandin;Michael D. Norenberg;Gregory Kennedy

  • Thiamine deficiency results in metabolic acidosis and energy failure in cerebellar granule cells: an in vitro model for the study of cell death mechanisms in Wernicke's encephalopathy.

    Pierre Pannunzio;Alan S. Hazell;Marc Pannunzio;K.V. Rama Rao

Frequent Co-Authors

Raghu Vemuganti
Raghu Vemuganti University of Wisconsin–Madison
David V. Pow
David V. Pow University of Queensland
Phillip F. Gardiner
Phillip F. Gardiner University of Manitoba
Niels C. Danbolt
Niels C. Danbolt University of Oslo
Iscia Lopes-Cendes
Iscia Lopes-Cendes State University of Campinas

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