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Biology and Biochemistry

D-Index
83
Citations
36372
World Ranking
3432
National Ranking
259

Research.com Recognitions

  • 1991 - Fellow of the Royal Society of Edinburgh

Overview

C. Peter Downes is affiliated with the University of Dundee in the United Kingdom and has contributed primarily to the fields of Biochemistry, Genetics and Molecular Biology. Their research output includes a significant focus on Molecular Biology, Physiology, and Surgery as subfields. The core scientific topics frequently addressed in their work consist of Protein Kinase Regulation and GTPase Signaling, PI3K/AKT/mTOR signaling in cancer, Adenosine and Purinergic Signaling, Cell death mechanisms and regulation, Metabolism, Diabetes, and Cancer, Pancreatic function and diabetes, and Calcium signaling and nucleotide metabolism.

Recent publications by C. Peter Downes include the following papers:

  • A receptor and G-protein-regulated polyphosphoinositide-specific phospholipase C from turkey erythrocytes. II. P2Y-purinergic receptor and G-protein-mediated regulation of the purified enzyme reconstituted with turkey erythrocyte ghosts., 2021, UNC Libraries
  • A receptor and G-protein-regulated polyphosphoinositide-specific phospholipase C from turkey erythrocytes. I. Purification and properties., 2021, UNC Libraries
  • Time-dependent inhibition of phospholipase C β -catalysed phosphoinositide hydrolysis: a comparison of different assays, 2020, UNC Libraries
  • Kinetics and activation of phospholipase C by P2Y purinergic agonists and guanine nucleotides, 2021, UNC Libraries

Frequent coauthors in their research work include:

  • Nicholas R. Leslie
  • Gary L Waldo
  • T. Kendall Harden
  • Jason E. Schaffer
  • Justin J. Miller

The primary venue for their publications has been UNC Libraries, where they have contributed to at least four works. Their scientific contributions have culminated in recognition such as the Fellowship of the Royal Society of Edinburgh awarded in 1991.

Best Publications

  • Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

    Dario R. Alessi;Stephen R. James;C.Peter Downes;Andrew B. Holmes

  • Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands.

    M J Berridge;C P Downes;M R Hanley

  • Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides.

    M J Berridge;R M C Dawson;C P Downes;J P Heslop

  • Neural and developmental actions of lithium: A unifying hypothesis

    Michael J. Berridge;C.Peter Downes;Michael R. Hanley

  • The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins.

    Laura S Harrington;Greg M Findlay;Alexander Gray;Tatiana Tolkacheva

  • Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate.

    M Whitman;C P Downes;M Keeler;T Keller

  • Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities.

    S Dowler;R A Currie;D G Campbell;M Deak

  • Redox regulation of PI 3-kinase signalling via inactivation of PTEN

    Nick R Leslie;Deborah Bennett;Yvonne E Lindsay;Hazel Stewart

  • Rapid breakdown of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in rat hepatocytes stimulated by vasopressin and other Ca2+-mobilizing hormones.

    J A Creba;C P Downes;P T Hawkins;G Brewster

  • The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane

    C P Downes;M C Mussat;R H Michell

  • The stimulation of inositol lipid metabolism that accompanies calcium mobilization in stimulated cells: defined characteristics and unanswered questions.

    Robert Hall Michell;C. J. Kirk;Lynne M. Jones;C. P. Downes

  • PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2

    Anudharan Balendran;Antonio Casamayor;Maria Deak;Andrew Paterson

  • A Crucial Role for the p110δ Subunit of Phosphatidylinositol 3-Kinase in B Cell Development and Activation

    Elizabeth Clayton;Giuseppe Bardi;Sarah E. Bell;David Chantry

  • PTEN function: how normal cells control it and tumour cells lose it

    Nick R Leslie;C Peter Downes

  • PTEN: The down side of PI 3-kinase signalling.

    Nick R. Leslie;C.Peter Downes

  • Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1.

    R A Currie;K S Walker;A Gray;M Deak

  • Tumor suppressor and anti-inflammatory actions of PPARγ agonists are mediated via upregulation of PTEN

    Lisa Patel;Ian Pass;Phil Coxon;C.Peter Downes

  • Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation

    Stephen R. James;C. Peter Downes;Roy Gigg;Simon J. A. Grove

  • Subcellular localization of phosphatidylinositol 4,5-bisphosphate using the pleckstrin homology domain of phospholipase C delta1.

    Stephen A Watt;Gursant Kular;Ian N Fleming;C Peter Downes

  • Inositol 1,3,4,5-tetrakisphosphate and not phosphatidylinositol 3,4-bisphosphate is the probable precursor of inositol 1,3,4-trisphosphate in agonist-stimulated parotid gland.

    C P Downes;P T Hawkins;R F Irvine

Frequent Co-Authors

Nick R. Leslie
Nick R. Leslie Heriot-Watt University
John M. Lucocq
John M. Lucocq University of St Andrews
Dario R. Alessi
Dario R. Alessi University of Dundee
Anthony D. Whetton
Anthony D. Whetton University of Manchester
Maria Deak
Maria Deak University of Dundee
Philip Cohen
Philip Cohen University of Dundee
Alan R. Prescott
Alan R. Prescott University of Dundee
Michael L. J. Ashford
Michael L. J. Ashford University of Dundee
Eric Hajduch
Eric Hajduch European Association for the Study of Diabetes
Andrew B. Holmes
Andrew B. Holmes University of Melbourne

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