What is he best known for?
The fields of study he is best known for:
Molecular biology, Proto-oncogene tyrosine-protein kinase Src, Cell biology, Rous sarcoma virus and SH2 domain are his primary areas of study.
Hidesaburo Hanafusa combines subjects such as Biochemistry, Gene, Avian sarcoma virus and SH3 domain, Receptor tyrosine kinase with his study of Molecular biology.
His Proto-oncogene tyrosine-protein kinase Src study combines topics from a wide range of disciplines, such as Kinase activity and Tyrosine phosphorylation.
His research in Cell biology focuses on subjects like Cancer research, which are connected to Cyclin A2.
His biological study spans a wide range of topics, including Helper virus and Oncovirus.
His SH2 domain study incorporates themes from PTK2, Protein phosphorylation, Paxillin and Adapter molecule crk.
His most cited work include:
- SH2 domains recognize specific phosphopeptide sequences (2506 citations)
- A novel viral oncogene with structural similarity to phospholipase C. (618 citations)
- CRYSTAL-STRUCTURE OF THE PHOSPHOTYROSINE RECOGNITION DOMAIN SH2 OF V-SRC COMPLEXED WITH TYROSINE-PHOSPHORYLATED PEPTIDES (561 citations)
What are the main themes of his work throughout his whole career to date?
Hidesaburo Hanafusa mainly investigates Molecular biology, Rous sarcoma virus, Proto-oncogene tyrosine-protein kinase Src, Avian sarcoma virus and Cell biology.
Hidesaburo Hanafusa interconnects Tyrosine, SH3 domain, Tyrosine kinase, Gene and Phosphorylation in the investigation of issues within Molecular biology.
His research integrates issues of Amino acid, Peptide sequence, Oncovirus and Viral transformation in his study of Rous sarcoma virus.
His Proto-oncogene tyrosine-protein kinase Src research includes themes of Tyrosine phosphorylation, Mutant and Kinase activity.
His research in Avian sarcoma virus intersects with topics in Cytoplasm, Genome, Viral replication, Nucleic acid thermodynamics and Membrane protein.
His SH2 domain research is multidisciplinary, incorporating perspectives in PTK2 and Protein phosphorylation.
He most often published in these fields:
- Molecular biology (56.90%)
- Rous sarcoma virus (35.78%)
- Proto-oncogene tyrosine-protein kinase Src (33.19%)
What were the highlights of his more recent work (between 1995-2016)?
- Cell biology (29.74%)
- Molecular biology (56.90%)
- Adapter molecule crk (15.95%)
In recent papers he was focusing on the following fields of study:
The scientist’s investigation covers issues in Cell biology, Molecular biology, Adapter molecule crk, Tyrosine phosphorylation and SH3 domain.
His Molecular biology study combines topics in areas such as Paxillin, Mutant, v-Src, Regulation of gene expression and Transcription.
The study incorporates disciplines such as Effector, Guanine nucleotide exchange factor and Focal adhesion in addition to Adapter molecule crk.
His Tyrosine phosphorylation research focuses on Protein tyrosine phosphatase and how it connects with Transmembrane protein and Platelet-derived growth factor receptor.
His SH3 domain research incorporates elements of Cyclin-dependent kinase 9 and Mitogen-activated protein kinase kinase.
His biological study focuses on SH2 domain.
Between 1995 and 2016, his most popular works were:
- TRANCE, a TNF Family Member, Activates Akt/PKB through a Signaling Complex Involving TRAF6 and c-Src (520 citations)
- Identification of the Product of Growth Arrest-specific Gene 6 as a Common Ligand for Axl, Sky, and Mer Receptor Tyrosine Kinases (416 citations)
- Evidence for a transcriptional activation function of BRCA1 C-terminal region (403 citations)
In his most recent research, the most cited papers focused on:
Hidesaburo Hanafusa spends much of his time researching Cell biology, Molecular biology, Tyrosine phosphorylation, Proto-oncogene tyrosine-protein kinase Src and Receptor tyrosine kinase.
His work carried out in the field of Cell biology brings together such families of science as Cancer research and Arp2/3 complex.
Hidesaburo Hanafusa interconnects Transcriptional regulation, Transactivation, Nuclear localization sequence, DNA-binding domain and Transformation in the investigation of issues within Molecular biology.
The Tyrosine phosphorylation study combines topics in areas such as Src family kinase and Kinase activity.
As part of his studies on Proto-oncogene tyrosine-protein kinase Src, Hidesaburo Hanafusa frequently links adjacent subjects like Adapter molecule crk.
His Adapter molecule crk research integrates issues from SH3 domain and SH2 domain.
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