World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
85
Citations
33562
World Ranking
3092
National Ranking
1565

Research.com Recognitions

  • 2012 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2006 - E. Mead Johnson Award, Society for Pediatric Research
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

David Pellman is affiliated with the Howard Hughes Medical Institute in the United States. Their research focuses primarily on biochemistry, genetics, and molecular biology, with significant contributions across related subfields including molecular biology, genetics, cell biology, cancer research, and plant science.

The scientist's published work spans several key topics that illustrate a diverse but interconnected range of research interests. These include:

  • Genomic variations and chromosomal abnormalities
  • Genomics and chromatin dynamics
  • DNA repair mechanisms
  • Cancer genomics and diagnostics
  • Microtubule and mitosis dynamics
  • Nuclear structure and function
  • CRISPR and genetic engineering

David Pellman's research output is featured in a variety of publication venues, reflecting a breadth of scientific inquiry and collaboration. Frequent publication forums include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Genetics
  • Nature
  • Nature Communications
  • Zenodo (CERN European Organization for Nuclear Research)

Notable recent papers authored or co-authored by David Pellman include the following publications:

  • "Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing," 2020, Nature Genetics
  • "Chromothripsis as an on-target consequence of CRISPR-Cas9 genome editing," 2021, Nature Genetics
  • "Mechanisms generating cancer genome complexity from a single cell division error," 2020, Science
  • "Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing," 2021, Nature Communications
  • "ERα-associated translocations underlie oncogene amplifications in breast cancer," 2023, Nature

Collaboration appears to be an integral part of Pellman's work, with frequent co-authors including:

  • Cheng-Zhong Zhang
  • Isidro Cortés-Ciriano
  • Jake June-Koo Lee
  • Lixing Yang
  • Dmitry A. Gordenin

The scientist has received recognition in the form of various awards and honors. These include being a Fellow of the American Association for the Advancement of Science (AAAS) since 2012, receiving the E. Mead Johnson Award from the Society for Pediatric Research in 2006, and membership in the Association of American Physicians.

Best Publications

  • Absolute quantification of somatic DNA alterations in human cancer

    Scott L Carter;Kristian Cibulskis;Elena Helman;Elena Helman;Aaron McKenna

  • A Mechanism Linking Extra Centrosomes to Chromosomal Instability

    Neil J. Ganem;Susana A. Godinho;David Pellman

  • DNA breaks and chromosome pulverization from errors in mitosis

    Karen Crasta;Neil J. Ganem;Neil J. Ganem;Regina Dagher;Regina Dagher;Alexandra B. Lantermann

  • Cytokinesis failure generating tetraploids promotes tumorigenesis in p53 -null cells

    Takeshi Fujiwara;Madhavi Bandi;Masayuki Nitta;Elena V. Ivanova

  • Chromothripsis from DNA damage in micronuclei

    Cheng-Zhong Zhang;Alexander Spektor;Hauke Cornils;Joshua M. Francis

  • Causes and consequences of aneuploidy in cancer

    David J. Gordon;Benjamin Resio;David Pellman

  • From polyploidy to aneuploidy, genome instability and cancer

    Zuzana Storchova;David Pellman

  • Tetraploidy, aneuploidy and cancer.

    Neil J Ganem;Zuzana Storchova;David Pellman

  • Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance

    Max A. Tischfield;Hagit N. Baris;Chen Wu;Guenther Rudolph

  • Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes

    Mijung Kwon;Susana A. Godinho;Namrata S. Chandhok;Neil J. Ganem

  • An actin nucleation mechanism mediated by Bni1 and Profilin

    Isabelle Sagot;Avital A. Rodal;James Moseley;Bruce L. Goode;Bruce L. Goode

  • Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

    Isidro Cortés-Ciriano;Jake June-Koo Lee;Ruibin Xi;Dhawal Jain

  • A short sequence in the p60src N terminus is required for p60src myristylation and membrane association and for cell transformation.

    F R Cross;E A Garber;D Pellman;H Hanafusa

  • Yeast formins regulate cell polarity by controlling the assembly of actin cables

    Isabelle Sagot;Saskia K. Klee;Saskia K. Klee;David Pellman

  • Crystal structures of a Formin Homology-2 domain reveal a tethered dimer architecture

    Yingwu Xu;James B. Moseley;Isabelle Sagot;Florence Poy

  • Polyploidy can drive rapid adaptation in yeast

    Anna M. Selmecki;Yosef E. Maruvka;Phillip A. Richmond;Marie Guillet;Marie Guillet

  • Microtubule "Plus-End-Tracking Proteins": The End Is Just the Beginning

    Scott C. Schuyler;David Pellman

  • Cytokinesis failure triggers hippo tumor suppressor pathway activation.

    Neil J. Ganem;Hauke Cornils;Shang-Yi Chiu;Kevin P. O’Rourke

  • Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

    Glenn S Cowley;Barbara A Weir;Barbara A Weir;Francisca Vazquez;Francisca Vazquez;Pablo Tamayo

  • Oncogene-like induction of cellular invasion from centrosome amplification

    Susana A. Godinho;Susana A. Godinho;Susana A. Godinho;Remigio Picone;Remigio Picone;Mithila Burute;Mithila Burute;Regina Dagher;Regina Dagher

Frequent Co-Authors

William C. Hahn
William C. Hahn Dana-Farber Cancer Institute
Zuzana Storchova
Zuzana Storchova Technical University of Kaiserslautern
Hidesaburo Hanafusa
Hidesaburo Hanafusa Osaka Bioscience Institute
Johannes C. Walter
Johannes C. Walter Harvard University
Barbara A. Weir
Barbara A. Weir Janssen (United States)
Bruce L. Goode
Bruce L. Goode Brandeis University
Francisca Vazquez
Francisca Vazquez Broad Institute
Matthew Meyerson
Matthew Meyerson Harvard University
Peter J. Park
Peter J. Park Harvard University

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