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D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
33321
World Ranking
12874
National Ranking
5477

Overview

Lei Chen is affiliated with Regeneron in the United States and works primarily in the field of Biochemistry, Genetics and Molecular Biology, contributing to 137 publications. Their research spans several subfields including Molecular Biology, Genetics, Plant Science, Biochemistry, and Ecology.

Their work addresses a variety of topics, notably in Genetic Mapping and Diversity in Plants and Animals, Genomics and Phylogenetic Studies, CRISPR and Genetic Engineering, Genetic and Phenotypic Traits in Livestock, Genetic Diversity and Population Structure, Plant Gene Expression Analysis, and Phytochemicals and Antioxidant Activities.

Lei Chen's recent scientific papers include:

  • The Earth BioGenome Project 2020: Starting the clock, 2022, Proceedings of the National Academy of Sciences
  • The origin of domestication genes in goats, 2020, Science Advances
  • Ancient and modern genomes unravel the evolutionary history of the rhinoceros family, 2021, Cell
  • A towering genome: Experimentally validated adaptations to high blood pressure and extreme stature in the giraffe, 2021, Science Advances
  • Molecular mechanisms and topological consequences of drastic chromosomal rearrangements of muntjac deer, 2021, Nature Communications

The scientist has collaborated frequently with other researchers, including:

  • Wen Wang (14 joint publications)
  • Rasmus Heller (9 joint publications)
  • Guichun Liu (8 joint publications)
  • Guojie Zhang (6 joint publications)
  • Botong Zhou (6 joint publications)

Lei Chen has published in various scientific venues, with notable recurring contributions to:

  • Frontiers in Genetics (4 publications)
  • Science Advances (3 publications)
  • Journal of Genetics and Genomics (3 publications)
  • (3 publications)
  • Mitochondrial DNA Part B (3 publications)

In addition to journal articles, Lei Chen has contributed to book publications, including a work published by Frontiers Media titled Application of Next Generation Sequencing (NGS) and CRISPR-Cas Systems in The Diagnosis of Infectious Diseases (2023).

Best Publications

  • Structure, function and diversity of the healthy human microbiome

    Curtis Huttenhower;Curtis Huttenhower;Dirk Gevers;Rob Knight;Rob Knight;Sahar Abubucker

  • A framework for human microbiome research

    Barbara A. Methé;Karen E. Nelson;Mihai Pop;Heather H. Creasy

  • The complete genome of an individual by massively parallel DNA sequencing

    David A. Wheeler;Maithreyan Srinivasan;Michael Egholm;Yufeng Shen

  • Evaluation of 16S rRNA gene sequencing for species and strain-level microbiome analysis

    Jethro S. Johnson;Daniel J. Spakowicz;Bo Young Hong;Lauren M. Petersen

  • Genome remodelling in a basal-like breast cancer metastasis and xenograft

    Li Ding;Matthew J C Ellis;Shunqiang Li;David E. Larson

  • Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus

    Jason S. McLellan;Man Chen;M. Gordon Joyce;Mallika Sastry

  • A Catalog of Reference Genomes from the Human Microbiome

    Karen E. Nelson;George M. Weinstock;Sarah K. Highlander

  • Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota

    Francesca Cignarella;Claudia Cantoni;Laura Ghezzi;Amber Salter

  • Longitudinal multi-omics of host–microbe dynamics in prediabetes

    Wenyu Zhou;M Reza Sailani;Kévin Contrepois;Yanjiao Zhou

  • Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility

    Marie Pancera;Shahzad Majeed;Yih-En Andrew Ban;Lei Chen

  • Structural basis of immune evasion at the site of CD4 attachment on HIV-1 gp120.

    Lei Chen;Young Do Kwon;Tongqing Zhou;Xueling Wu

  • Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody

    Rui Kong;Kai Xu;Tongqing Zhou;Priyamvada Acharya

  • Structural repertoire of HIV-1-neutralizing antibodies targeting the CD4 supersite in 14 donors

    Tongqing Zhou;Rebecca M. Lynch;Lei Chen;Priyamvada Acharya

  • Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody

    Mattia Bonsignori;Tongqing Zhou;Zizhang Sheng;Lei Chen

  • Large scale variation in Enterococcus faecalis illustrated by the genome analysis of strain OG1RF

    Agathe Bourgogne;Danielle A Garsin;Xiang Qin;Kavindra V Singh

  • Community characteristics of the gut microbiomes of competitive cyclists

    Lauren M. Petersen;Eddy J. Bautista;Hoan Nguyen;Blake M. Hanson

  • Differential soil fungus accumulation and density dependence of trees in a subtropical forest

    Lei Chen;Nathan G. Swenson;Niuniu Ji;Xiangcheng Mi

  • A SNP discovery method to assess variant allele probability from next-generation resequencing data.

    Yufeng Shen;Zhengzheng Wan;Cristian Coarfa;Rafal Drabek

  • Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development

    Marilyn B Renfree;Marilyn B Renfree;Anthony T Papenfuss;Anthony T Papenfuss;Anthony T Papenfuss;Janine E Deakin;Janine E Deakin;James Lindsay

  • Community-level consequences of density dependence and habitat association in a subtropical broad-leaved forest

    Lei Chen;Xiangcheng Mi;Liza S. Comita;Liwen Zhang

Frequent Co-Authors

George M. Weinstock
George M. Weinstock The Jackson Laboratory
Tongqing Zhou
Tongqing Zhou National Institutes of Health
Peter D. Kwong
Peter D. Kwong Columbia University Medical Center
Richard A. Gibbs
Richard A. Gibbs Baylor College of Medicine
Donna M. Muzny
Donna M. Muzny Baylor College of Medicine
Xiang Qin
Xiang Qin Baylor College of Medicine
Marie Pancera
Marie Pancera Fred Hutchinson Cancer Research Center
Yongping Yang
Yongping Yang National Institutes of Health
Ivelin S. Georgiev
Ivelin S. Georgiev Vanderbilt University Medical Center
Lucinda Fulton
Lucinda Fulton Washington University in St. Louis

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