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Immunology

D-Index
49
Citations
13688
World Ranking
4301
National Ranking
45

Overview

Sine Reker Hadrup is affiliated with the Technical University of Denmark in Denmark. Their research primarily focuses on medicine, immunology and microbiology, and biochemistry, genetics, and molecular biology. The scientist's work intersects key areas such as oncology, immunology, molecular biology, genetics, and radiology, nuclear medicine, and imaging.

The main research topics covered in their publications include:

  • CAR-T cell therapy research
  • Immunotherapy and immune responses
  • Cancer immunotherapy and biomarkers
  • Vaccines and immunoinformatics approaches
  • T-cell and B-cell immunology
  • Immune cell function and interaction
  • Monoclonal and polyclonal antibodies research

Sine Reker Hadrup has contributed several recent papers, highlighting varied aspects of immunology and cancer biology. Notable publications include:

  • Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition, 2021, Cell
  • SARS-CoV-2 genome-wide T cell epitope mapping reveals immunodominance and substantial CD8 + T cell activation in COVID-19 patients, 2021, Science Immunology
  • NetTCR-2.0 enables accurate prediction of TCR-peptide binding by using paired TCRα and β sequence data, 2021, Communications Biology
  • The T cell differentiation landscape is shaped by tumour mutations in lung cancer, 2020, Nature Cancer
  • Human endogenous retroviruses form a reservoir of T cell targets in hematological cancers, 2020, Nature Communications

The scientist frequently publishes in venues such as bioRxiv (Cold Spring Harbor Laboratory), Frontiers in Immunology, Nature Communications, The Journal of Immunology, and Nature Cancer. These platforms have supported multiple papers in their research areas.

Collaboration is a significant aspect of their scientific endeavors. Frequent co-authors include:

  • Inge Marie Svane
  • Tripti Tamhane
  • Sunil Kumar Saini
  • Amalie Kai Bentzen
  • Annie Borch

Best Publications

  • Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade

    Nicholas McGranahan;Nicholas McGranahan;Andrew J. S. Furness;Rachel Rosenthal;Sofie Ramskov

  • Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition

    Kevin Litchfield;Kevin Litchfield;James L. Reading;Clare Puttick;Krupa Thakkar;Krupa Thakkar

  • Generation of peptide-MHC class I complexes through UV-mediated ligand exchange.

    Boris Rodenko;Mireille Toebes;Sine Reker Hadrup;Wim J E van Esch

  • Longitudinal Studies of Clonally Expanded CD8 T Cells Reveal a Repertoire Shrinkage Predicting Mortality and an Increased Number of Dysfunctional Cytomegalovirus-Specific T Cells in the Very Elderly

    Sine Reker Hadrup;Jan Strindhall;Tania Køllgaard;Tina Seremet

  • Parallel detection of antigen-specific T cell responses by combinatorial encoding of MHC multimers

    Rikke Sick Andersen;Pia Kvistborg;Thomas Mørch Frøsig;Thomas Mørch Frøsig;Natasja Wulff Pedersen

  • Neoantigen landscape dynamics during human melanoma–T cell interactions

    Els M. E. Verdegaal;Noel F. C. C. de Miranda;Marten Visser;Tom Harryvan

  • Effector CD4 and CD8 T Cells and Their Role in the Tumor Microenvironment

    Sine Reker Hadrup;Marco Donia;Per Thor Straten

  • Parallel detection of antigen-specific T-cell responses by multidimensional encoding of MHC multimers.

    Sine Reker Hadrup;Sine Reker Hadrup;Arnold H Bakker;Arnold H Bakker;Chengyi J Shu;Rikke S Andersen

  • Large-scale detection of antigen-specific T cells using peptide-MHC-I multimers labeled with DNA barcodes

    Amalie Kai Bentzen;Andrea Marion Marquard;Rikke Lyngaa;Sunil Kumar Saini

  • MuPeXI: prediction of neo-epitopes from tumor sequencing data.

    Anne-Mette Bjerregaard;Morten Nielsen;Sine Reker Hadrup;Zoltan Imre Szallasi;Zoltan Imre Szallasi

  • NetTCR-2.0 enables accurate prediction of TCR-peptide binding by using paired TCRα and β sequence data.

    Alessandro Montemurro;Viktoria Schuster;Helle Rus Povlsen;Amalie Kai Bentzen

  • SARS-CoV-2 genome-wide T cell epitope mapping reveals immunodominance and substantial CD8 + T cell activation in COVID-19 patients.

    Sunil Kumar Saini;Ditte Stampe Hersby;Tripti Tamhane;Helle Rus Povlsen

  • Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer

    Kroopa Joshi;Kroopa Joshi;Marc Robert de Massy;Mazlina Ismail;James L. Reading

  • TIL therapy broadens the tumor-reactive CD8+ T cell compartment in melanoma patients

    Pia Kvistborg;Chengyi Jenny Shu;Bianca Heemskerk;Manuel Fankhauser

  • High-throughput identification of antigen-specific TCRs by TCR gene capture

    Carsten Linnemann;Bianca Heemskerk;Pia Kvistborg;Roelof J C Kluin

  • Adoptive cell therapy with autologous tumor infiltrating lymphocytes and low-dose Interleukin-2 in metastatic melanoma patients

    Eva Ellebaek;Trine Zeeberg Iversen;Niels Junker;Marco Donia;Marco Donia

  • Conditional MHC class I ligands and peptide exchange technology for the human MHC gene products HLA-A1, -A3, -A11, and -B7

    Arnold H. Bakker;Rieuwert Hoppes;Carsten Linnemann;Mireille Toebes

  • Dissection of T cell antigen specificity in human melanoma

    Rikke Sick Andersen;Charlotte Albæk Thrue;Niels Junker;Rikke Birgitte Lyngaa

  • Indoleamine 2,3-dioxygenase specific, cytotoxic T cells as immune regulators.

    Rikke Bæk Sørensen;Sine Reker Hadrup;Inge Marie Svane;Mads Christian Hjortsø

  • Metastatic melanoma patients treated with dendritic cell vaccination, Interleukin-2 and metronomic cyclophosphamide: results from a phase II trial

    Eva Ellebaek;Lotte Engell-Noerregaard;Trine Zeeberg Iversen;Thomas Moerch Froesig;Thomas Moerch Froesig

  • Modular Nucleic Acid Assembled p/MHC Microarrays for Multiplexed Sorting of Antigen-Specific T Cells

    Gabriel A. Kwong;Caius G. Radu;Kiwook Hwang;Chengyi J. Shu

  • T-cell Responses to Oncogenic Merkel Cell Polyomavirus Proteins Distinguish Patients with Merkel Cell Carcinoma from Healthy Donors

    Rikke Birgitte Lyngaa;Natasja Wulff Pedersen;David Schrama;Charlotte Albaek Thrue

Frequent Co-Authors

Inge Marie Svane
Inge Marie Svane Copenhagen University Hospital
Per thor Straten
Per thor Straten University of Copenhagen
Marco Donia
Marco Donia Copenhagen University Hospital
Ton N. M. Schumacher
Ton N. M. Schumacher Antoni van Leeuwenhoek Hospital
Mads Hald Andersen
Mads Hald Andersen Copenhagen University Hospital
Zoltan Szallasi
Zoltan Szallasi Boston Children's Hospital
Charles Swanton
Charles Swanton The Francis Crick Institute
Morten Nielsen
Morten Nielsen Technical University of Denmark
Jürgen C. Becker
Jürgen C. Becker University of Duisburg-Essen
Sergio A. Quezada
Sergio A. Quezada University College London

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