Jennifer L. McKimm-Breschkin

Best Publications

• ER Stress Triggers Apoptosis by Activating BH3-Only Protein Bim

  Hamsa Puthalakath;Lorraine A. O'Reilly;Priscilla Gunn;Lily Lee

  1678
  Citations

• The structure of the complex between influenza virus neuraminidase and sialic acid, the viral receptor

  Joseph N. Varghese;Jennifer L. McKimm-Breschkin;James B. Caldwell;Alexander A. Kortt

  519
  Citations

• Resistance of influenza viruses to neuraminidase inhibitors--a review.

  Unknown

  503
  Citations

• Influenza Virus Neuraminidase Structure and Functions.

  Julie L. McAuley;Brad P. Gilbertson;Sanja Trifkovic;Sanja Trifkovic;Lorena E. Brown

  476
  Citations

• Detection of Influenza Viruses Resistant to Neuraminidase Inhibitors in Global Surveillance during the First 3 Years of Their Use

  Arnold S. Monto;Jennifer L. McKimm-Breschkin;Catherine Macken;Alan W. Hampson

  467
  Citations

• Influenza neuraminidase inhibitors: antiviral action and mechanisms of resistance

  Unknown

  448
  Citations

• Neuraminidase Sequence Analysis and Susceptibilities of Influenza Virus Clinical Isolates to Zanamivir and Oseltamivir

  J. McKimm-Breschkin;T. Trivedi;A. Hampson;A. Hay

  408
  Citations

• The structure of the fusion glycoprotein of Newcastle disease virus suggests a novel paradigm for the molecular mechanism of membrane fusion.

  Lin Chen;Jeffrey J Gorman;Jenny McKimm-Breschkin;Lynne J Lawrence

  295
  Citations

• Evaluation of Neuraminidase Enzyme Assays Using Different Substrates To Measure Susceptibility of Influenza Virus Clinical Isolates to Neuraminidase Inhibitors: Report of the Neuraminidase Inhibitor Susceptibility Network

  N. T. Wetherall;T. Trivedi;J. Zeller;C. Hodges-Savola

  293
  Citations

• Structure of the Haemagglutinin-neuraminidase from Human Parainfluenza Virus Type III

  Michael C. Lawrence;Natalie A. Borg;Victor A. Streltsov;Patricia A. Pilling

  267
  Citations

• Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.

  Joseph N Varghese;Paul W Smith;Steven L Sollis;Tony J Blick

  259
  Citations

• Interferon-γ induces the expression of H-2 and Ia antigens on brain cells

  Grace H.W. Wong;Perry F. Bartlett;Ian Clark-Lewis;Jenny L. McKimm-Breschkin

  245
  Citations

• Mutations in a Conserved Residue in the Influenza Virus Neuraminidase Active Site Decreases Sensitivity to Neu5Ac2en-Derived Inhibitors

  Jennifer L. McKimm-Breschkin;Anjali Sahasrabudhe;Tony J. Blick;Mandy McDonald

  243
  Citations

• Generation and characterization of variants of NWS/G70C influenza virus after in vitro passage in 4-amino-Neu5Ac2en and 4-guanidino-Neu5Ac2en.

  Unknown

  230
  Citations

• Mechanism-Based Covalent Neuraminidase Inhibitors with Broad Spectrum Influenza Antiviral Activity

  Jin-Hyo Kim;Ricardo Resende;Tom Wennekes;Hong-Ming Chen

  218
  Citations

• Generation and Characterization of an Influenza Virus Neuraminidase Variant with Decreased Sensitivity to the Neuraminidase-Specific Inhibitor 4-Guanidino-Neu5Ac2en

  Tony J. Blick;Tak Tiong;Anjali Sahasrabudhe;Joseph N. Varghese

  184
  Citations

• Reduced sensitivity of influenza A (H5N1) to oseltamivir.

  Unknown

  170
  Citations

• Structural evidence for a second sialic acid binding site in avian influenza virus neuraminidases

  J N Varghese;P M Colman;A van Donkelaar;T J Blick

  167
  Citations

• The Interaction of Neuraminidase and Hemagglutinin Mutations in Influenza Virus in Resistance to 4-Guanidino-Neu5Ac2en

  Unknown

  154
  Citations

• The structure of a complex between the NC10 antibody and influenza virus neuraminidase and comparison with the overlapping binding site of the NC41 antibody

  Robyn L Malby;William R Tulip;Vincent R Harley;Jennifer L McKimm-Breschkin

  143
  Citations