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D-Index & Metrics

Biology and Biochemistry

D-Index
48
Citations
10731
World Ranking
18275
National Ranking
28

Overview

Petr Svoboda is affiliated with the Czech Academy of Sciences in the Czech Republic. Their research primarily focuses on biochemistry, genetics, and molecular biology, with additional work in agricultural and biological sciences. Within these domains, they have concentrated on molecular biology, plant science, cancer research, immunology, and infectious diseases as key subfields of study.

Their main topics include RNA interference and gene delivery, microRNA in disease regulation, chromosomal and genetic variations, CRISPR and genetic engineering, RNA modifications and cancer, RNA research and splicing, and circular RNAs in diseases.

Their recent published papers include:

  • Key Mechanistic Principles and Considerations Concerning RNA Interference, 2020, Frontiers in Plant Science
  • Structural and functional basis of mammalian microRNA biogenesis by Dicer, 2022, Molecular Cell
  • Formation of spermatogonia and fertile oocytes in golden hamsters requires piRNAs, 2021, Nature Cell Biology
  • Dicer structure and function: conserved and evolving features, 2023, EMBO Reports
  • MicroRNA dilution during oocyte growth disables the microRNA pathway in mammalian oocytes, 2020, Nucleic Acids Research

Frequent co-authors in their research are Filip Horvat, Radek Malík, Josef Pasulka, Eliška Táborská, and Zuzana Loubalová.

Petr Svoboda has published multiple works in prominent venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nucleic Acids Research
  • EMBO Reports
  • Frontiers in Plant Science
  • Molecular Cell

In addition to research articles, they have contributed to academic literature with a book published by Nakladatelství Karolinum entitled Introduction to RNAi and miRNA pathways in 2020.

Best Publications

  • Selective reduction of dormant maternal mRNAs in mouse oocytes by RNA interference

    Petr Svoboda;Paula Stein;Harutoshi Hayashi;Richard M. Schultz

  • MicroRNAs control de novo DNA methylation through regulation of transcriptional repressors in mouse embryonic stem cells

    Lasse Sinkkonen;Tabea Hugenschmidt;Philipp Berninger;Dimos Gaidatzis

  • Disruption of the Mouse mTOR Gene Leads to Early Postimplantation Lethality and Prohibits Embryonic Stem Cell Development

    Yann-Gaël Gangloff;Matthias Mueller;Stephen G. Dann;Petr Svoboda

  • Transgenic RNAi Reveals Essential Function for CTCF in H19 Gene Imprinting

    Andrew M. Fedoriw;Paula Stein;Paula Stein;Petr Svoboda;Petr Svoboda;Richard M. Schultz;Richard M. Schultz

  • Maternal BRG1 regulates zygotic genome activation in the mouse

    Scott J. Bultman;Thomas C. Gebuhr;Thomas C. Gebuhr;Hua Pan;Petr Svoboda;Petr Svoboda

  • A Retrotransposon-Driven Dicer Isoform Directs Endogenous Small Interfering RNA Production in Mouse Oocytes

    Matyas Flemr;Radek Malik;Vedran Franke;Jana Nejepinska

  • Effects of Dicer and Argonaute down-regulation on mRNA levels in human HEK293 cells

    Daniela Schmitter;Jody Filkowski;Alain Sewer;Ramesh S. Pillai

  • MicroRNA activity is suppressed in mouse oocytes

    Jun Ma;Matyas Flemr;Paula Stein;Philipp Berninger

  • Hairpin RNA: a secondary structure of primary importance

    P. Svoboda;A. Di. Cara

  • RNAi and expression of retrotransposons MuERV-L and IAP in preimplantation mouse embryos.

    Petr Svoboda;Paula Stein;Martin Anger;Emily Bernstein

  • RNAi in mouse oocytes and preimplantation embryos: effectiveness of hairpin dsRNA.

    Petr Svoboda;Paula Stein;Richard M. Schultz

  • Stimulation of beta-adrenergic receptors of S49 lymphoma cells redistributes the alpha subunit of the stimulatory G protein between cytosol and membranes.

    Lennart A. Ransnas;Petr Svoboda;Jeffrey R. Jasper;Paul A. Insel

  • Transgenic RNAi in mouse oocytes: a simple and fast approach to study gene function.

    Paula Stein;Petr Svoboda;Richard M Schultz

  • RNAi: mammalian oocytes do it without RNA-dependent RNA polymerase.

    Paula Stein;Petr Svoboda;Martin Anger;Richard M. Schultz

  • P-Body Loss Is Concomitant with Formation of a Messenger RNA Storage Domain in Mouse Oocytes

    Matyas Flemr;Jun Ma;Richard M. Schultz;Petr Svoboda

  • Off-targeting and other non-specific effects of RNAi experiments in mammalian cells.

    Petr Svoboda

  • Reprogramming of gene expression during preimplantation development

    Richard M. Schultz;Warren Davis;Paula Stein;Petr Svoboda

  • Regulation of Zygotic Gene Activation in the Preimplantation Mouse Embryo: Global Activation and Repression of Gene Expression

    Jun Ma;Jun Ma;Petr Svoboda;Richard M. Schultz;Paula Stein

  • Stochastic NANOG fluctuations allow mouse embryonic stem cells to explore pluripotency

    Elsa Abranches;Ana M. V. Guedes;Martin Moravec;Hedia Maamar

  • Review Hairpin RNA: a secondary structure of primary importance

    P. Svoboda;A. Di Cara;Friedrich Miescher

Frequent Co-Authors

Richard M. Schultz
Richard M. Schultz University of Pennsylvania
Jun Ma
Jun Ma University of Pennsylvania
Martin Alda
Martin Alda Dalhousie University
Yutaka Suzuki
Yutaka Suzuki University of Tokyo
Witold Filipowicz
Witold Filipowicz Friedrich Miescher Institute
Mihaela Zavolan
Mihaela Zavolan University of Basel
Graeme Milligan
Graeme Milligan University of Glasgow
Barbara Cannon
Barbara Cannon Stockholm University
Marisa S. Bartolomei
Marisa S. Bartolomei University of Pennsylvania
Paul A. Insel
Paul A. Insel University of California, San Diego

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