World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
61
Citations
11131
World Ranking
11535
National Ranking
366

Overview

Heng-Yu Fan is affiliated with Zhejiang University in China and has an extensive publication record primarily in biochemistry, genetics, and molecular biology, with additional work in medicine. Their research spans several subfields including molecular biology, public health, pediatrics, genetics, and cancer research.

Their recent papers cover a range of topics related to reproductive biology, RNA research, and metabolic processes during early development. Notable publications include:

  • "Dynamics and clinical relevance of maternal mRNA clearance during the oocyte-to-embryo transition in humans" (2020, Nature Communications)
  • "Ultrasensitive Ribo-seq reveals translational landscapes during mammalian oocyte-to-embryo transition and pre-implantation development" (2022, Nature Cell Biology)
  • "Metformin inhibits testosterone-induced endoplasmic reticulum stress in ovarian granulosa cells via inactivation of p38 MAPK" (2020, Human Reproduction)
  • "Metabolic remodelling during early mouse embryo development" (2021, Nature Metabolism)
  • "Homozygous Mutations in BTG4 Cause Zygotic Cleavage Failure and Female Infertility" (2020, The American Journal of Human Genetics)

Their frequent co-authors include Qian-Qian Sha, Yun-Wen Wu, Songying Zhang, Li Shen, and Jiamin Jin. These collaborations have led to multiple joint publications.

Publication venues where Heng-Yu Fan frequently publishes include:

  • Nucleic Acids Research
  • Advanced Science
  • Nature Communications
  • Human Reproduction
  • Development

The scientist's work focuses on several specific research topics, such as:

  • RNA Research and Splicing
  • RNA modifications and cancer
  • Reproductive Biology and Fertility
  • Epigenetics and DNA Methylation
  • Genomics and Chromatin Dynamics
  • Renal and related cancers
  • Cancer-related gene regulation

Heng-Yu Fan's body of work demonstrates a combination of experimental and theoretical approaches contributing to the understanding of molecular mechanisms in early development, fertility, and cancer biology. Their contributions span both fundamental biological processes and applied research in human health contexts.

Best Publications

  • MAPK3/1 (ERK1/2) in Ovarian Granulosa Cells Are Essential for Female Fertility

    Heng-Yu Fan;Zhilin Liu;Masayuki Shimada;Esta Sterneck

  • Involvement of Mitogen-Activated Protein Kinase Cascade During Oocyte Maturation and Fertilization in Mammals

    Heng-Yu Fan;Heng-Yu Fan;Qing-Yuan Sun

  • BTG4 is a meiotic cell cycle-coupled maternal-zygotic-transition licensing factor in oocytes

    Chao Yu;Shu-Yan Ji;Qian-Qian Sha;Yujiao Dang

  • High salt primes a specific activation state of macrophages, M(Na)

    Wu-Chang Zhang;Xiao-Jun Zheng;Lin-Juan Du;Jian-Yong Sun

  • Targeted disruption of Pten in ovarian granulosa cells enhances ovulation and extends the life span of luteal cells.

    Heng-Yu Fan;Zhilin Liu;Nicola Cahill;JoAnne S. Richards

  • Mechanisms regulating oocyte meiotic resumption: roles of mitogen-activated protein kinase.

    Cheng-Guang Liang;You-Qiang Su;Heng-Yu Fan;Heide Schatten

  • β-Catenin (CTNNB1) Promotes Preovulatory Follicular Development but Represses LH-Mediated Ovulation and Luteinization

    Heng-Yu Fan;Annalouise O'Connor;Manami Shitanaka;Masayuki Shimada

  • Selective expression of KrasG12D in granulosa cells of the mouse ovary causes defects in follicle development and ovulation

    Heng Yu Fan;Masayuki Shimada;Zhilin Liu;Nicola Cahill

  • YAP Promotes Ovarian Cancer Cell Tumorigenesis and Is Indicative of a Poor Prognosis for Ovarian Cancer Patients

    Yan Xia;Ting Chang;Yingmei Wang;Yixiong Liu

  • CCAAT/Enhancer-Binding Proteins (C/EBP)-α and -β Are Essential for Ovulation, Luteinization, and the Expression of Key Target Genes

    Heng-Yu Fan;Zhilin Liu;Peter F. Johnson;JoAnne S. Richards

  • Follicle-stimulating hormone induces multiple signaling cascades: evidence that activation of Rous sarcoma oncogene, RAS, and the epidermal growth factor receptor are critical for granulosa cell differentiation.

    Chad M. Wayne;Heng Yu Fan;Xiaodong Cheng;JoAnne S. Richards

  • A story of birth and death: mRNA translation and clearance at the onset of maternal-to-zygotic transition in mammals†.

    Qian-Qian Sha;Jue Zhang;Heng-Yu Fan;Heng-Yu Fan

  • Interleukin-6: An Autocrine Regulator of the Mouse Cumulus Cell-Oocyte Complex Expansion Process

    Zhilin Liu;Daniel G. de Matos;Heng-Yu Fan;Masayuki Shimada

  • FSH and FOXO1 Regulate Genes in the Sterol/Steroid and Lipid Biosynthetic Pathways in Granulosa Cells

    Zhilin Liu;Michael D. Rudd;Inmaculata Hernandez-Gonzalez;Ignacio Gonzalez-Robayna

  • Oocyte-expressed yes-associated protein is a key activator of the early zygotic genome in mouse.

    Chao Yu;Shu Yan Ji;Yu Jiao Dang;Qian Qian Sha

  • Mitoguardin Regulates Mitochondrial Fusion through MitoPLD and Is Required for Neuronal Homeostasis

    Yongping Zhang;Xiaoman Liu;Jian Bai;Xuejun Tian

  • CRL4 Complex Regulates Mammalian Oocyte Survival and Reprogramming by Activation of TET Proteins

    Chao Yu;Yin-Li Zhang;Wei-Wei Pan;Xiao-Meng Li

  • A MAPK cascade couples maternal mRNA translation and degradation to meiotic cell cycle progression in mouse oocytes

    Qian Qian Sha;Xing Xing Dai;Yujiao Dang;Fuchou Tang

  • Polo-Like Kinase-1 Is a Pivotal Regulator of Microtubule Assembly During Mouse Oocyte Meiotic Maturation, Fertilization, and Early Embryonic Mitosis

    Chao Tong;Heng-Yu Fan;Li Lian;Shi-Wen Li

  • Dynamics and clinical relevance of maternal mRNA clearance during the oocyte-to-embryo transition in humans

    Qian-Qian Sha;Wei Zheng;Yun-Wen Wu;Sen Li

Frequent Co-Authors

Qing-Yuan Sun
Qing-Yuan Sun Chinese Academy of Sciences
JoAnne S. Richards
JoAnne S. Richards Baylor College of Medicine
Heide Schatten
Heide Schatten University of Missouri
Li Shen
Li Shen University of Pennsylvania
Jun-Ping Liu
Jun-Ping Liu Hangzhou Normal University
Mingyao Liu
Mingyao Liu University Health Network
Fuchou Tang
Fuchou Tang Peking University
Peter F. Johnson
Peter F. Johnson National Institutes of Health
Jiahao Sha
Jiahao Sha Nanjing Medical University
Gang Zhang
Gang Zhang Agency for Science, Technology and Research

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