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Nobuhiko Kayagaki

Nobuhiko Kayagaki

D-Index & Metrics

Biology and Biochemistry

D-Index
70
Citations
30473
World Ranking
6853
National Ranking
3161

Overview

Nobuhiko Kayagaki is a researcher affiliated with Genentech in the United States. Their academic work primarily focuses on the fields of Biochemistry, Genetics and Molecular Biology, with additional contributions in Medicine. Within these domains, their subfields of study include Molecular Biology, Immunology, Epidemiology, Biophysics, and Hematology.

The scientist's publications cover several key topics, including Inflammasome and immune disorders, Cell death mechanisms and regulation, Heme Oxygenase-1 and Carbon Monoxide, Immune Response and Inflammation, Autophagy in Disease and Therapy, Autoimmune and Inflammatory Disorders Research, and Gout, Hyperuricemia, Uric Acid.

Notable recent papers authored or co-authored by Kayagaki include:

  • "NINJ1 mediates plasma membrane rupture during lytic cell death" (2021, Nature)
  • "Cell death" (2024, Cell)
  • "Dying cells fan the flames of inflammation" (2021, Science)
  • "Shigella ubiquitin ligase IpaH7.8 targets gasdermin D for degradation to prevent pyroptosis and enable infection" (2021, Cell Host & Microbe)
  • "Selective activation of PFKL suppresses the phagocytic oxidative burst" (2021, Cell)

Frequent co-authors in their research include Vishva M. Dixit, Kim Newton, Opher S. Kornfeld, Irma B. Stowe, and Joshua D. Webster. Kayagaki has collaborated extensively with these researchers, indicating a networked approach to their work.

The main publication venues for Kayagaki's research are:

  • Nature
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell
  • Nature Biotechnology
  • Science

Overall, Kayagaki's research contributions center on molecular mechanisms governing inflammation and immune response, with a significant focus on understanding cell death pathways and their implications for immune disorders.

Best Publications

  • Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

    Nobuhiko Kayagaki;Irma B. Stowe;Bettina L. Lee;Karen O’Rourke

  • Non-canonical inflammasome activation targets caspase-11

    Nobuhiko Kayagaki;Søren Warming;Mohamed Lamkanfi;Lieselotte Vande Walle

  • Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

    Nobuhiko Kayagaki;Michael T. Wong;Irma B. Stowe;Sree Ranjani Ramani

  • IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis.

    Eugene Varfolomeev;John W. Blankenship;Sarah M. Wayson;Anna V. Fedorova

  • Metalloproteinase-mediated release of human Fas ligand.

    N Kayagaki;A Kawasaki;T Ebata;H Ohmoto

  • Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death.

    Pontus Orning;Pontus Orning;Dan Weng;Dan Weng;Kristian Starheim;Kristian Starheim;Dmitry Ratner

  • Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells.

    Kazuyoshi Takeda;Yoshihiro Hayakawa;Mark J. Smyth;Nobuhiko Kayagaki

  • GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

    Robin A. Aglietti;Alberto Estevez;Aaron Gupta;Monica Gonzalez Ramirez

  • NINJ1 mediates plasma membrane rupture during lytic cell death

    Nobuhiko Kayagaki;Opher S. Kornfeld;Bettina L. Lee;Irma B. Stowe

  • Type I Interferons (IFNs) Regulate Tumor Necrosis Factor–related Apoptosis-inducing Ligand (TRAIL) Expression on Human T Cells: A Novel Mechanism for the Antitumor Effects of Type I IFNs

    Nobuhiko Kayagaki;Noriko Yamaguchi;Masafumi Nakayama;Hiroshi Eto

  • Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (Trail) Contributes to Interferon γ–Dependent Natural Killer Cell Protection from Tumor Metastasis

    Mark J. Smyth;Erika Cretney;Kazuyoshi Takeda;Robert H. Wiltrout

  • Critical Role for Tumor Necrosis Factor–related Apoptosis-inducing Ligand in Immune Surveillance Against Tumor Development

    Kazuyoshi Takeda;Mark J. Smyth;Erika Cretney;Yoshihiro Hayakawa

  • BAFF/BLyS Receptor 3 Binds the B Cell Survival Factor BAFF Ligand through a Discrete Surface Loop and Promotes Processing of NF-κB2

    Nobuhiko Kayagaki;Minhong Yan;Dhaya Seshasayee;Hua Wang

  • Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1

    Petr Broz;Thomas Ruby;Kamila Belhocine;Donna M. Bouley

  • Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis

    Jonathan W. Jones;Nobuhiko Kayagaki;Petr Broz;Thomas Henry

  • Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases

    Etienne Meunier;Mathias S. Dick;Roland F. Dreier;Nura Schürmann

  • DUBA: a deubiquitinase that regulates type I interferon production.

    Nobuhiko Kayagaki;Qui Phung;Salina Chan;Ruchir Chaudhari

  • Expression and function of TNF-related apoptosis-inducing ligand on murine activated NK cells.

    Nobuhiko Kayagaki;Noriko Yamaguchi;Masafumi Nakayama;Kazuyoshi Takeda

  • Antitumor effect of locally produced CD95 ligand

    Ken-Ichiro Seino;Nobuhiko Kayagaki;Ko Okumura;Hideo Yagita

  • Perforin, Fas/Fas ligand, and TNF-alpha pathways as specific and bystander killing mechanisms of hepatitis C virus-specific human CTL.

    K Ando;K Hiroishi;T Kaneko;T Moriyama

Frequent Co-Authors

Hideo Yagita
Hideo Yagita Juntendo University
Ko Okumura
Ko Okumura Juntendo University
Kazuyoshi Takeda
Kazuyoshi Takeda Juntendo University
Haruki Okamura
Haruki Okamura Hyogo College of Medicine
Hiroko Tsutsui
Hiroko Tsutsui Hyogo College of Medicine
Kenji Nakanishi
Kenji Nakanishi Hyogo College of Medicine
Mark J. Smyth
Mark J. Smyth QIMR Berghofer Medical Research Institute
Hisaya Akiba
Hisaya Akiba Juntendo University
Tetsuji Kobata
Tetsuji Kobata Tokyo Medical and Dental University
Toshikazu Shirai
Toshikazu Shirai Juntendo University

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