World's Best Scientists 2026 revealed!
Nobuhiko Kayagaki

Nobuhiko Kayagaki

D-Index & Metrics

Biology and Biochemistry

D-Index
70
Citations
30473
World Ranking
6853
National Ranking
3161

Nobuhiko Kayagaki publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Nobuhiko Kayagaki sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 113 publications — 9th percentile

9% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Nobuhiko Kayagaki D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Nobuhiko Kayagaki sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 70 D-Index — 65th percentile

65% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Nobuhiko Kayagaki is a researcher affiliated with Genentech in the United States. Their academic work primarily focuses on the fields of Biochemistry, Genetics and Molecular Biology, with additional contributions in Medicine. Within these domains, their subfields of study include Molecular Biology, Immunology, Epidemiology, Biophysics, and Hematology.

The scientist's publications cover several key topics, including Inflammasome and immune disorders, Cell death mechanisms and regulation, Heme Oxygenase-1 and Carbon Monoxide, Immune Response and Inflammation, Autophagy in Disease and Therapy, Autoimmune and Inflammatory Disorders Research, and Gout, Hyperuricemia, Uric Acid.

Notable recent papers authored or co-authored by Kayagaki include:

  • "NINJ1 mediates plasma membrane rupture during lytic cell death" (2021, Nature)
  • "Cell death" (2024, Cell)
  • "Dying cells fan the flames of inflammation" (2021, Science)
  • "Shigella ubiquitin ligase IpaH7.8 targets gasdermin D for degradation to prevent pyroptosis and enable infection" (2021, Cell Host & Microbe)
  • "Selective activation of PFKL suppresses the phagocytic oxidative burst" (2021, Cell)

Frequent co-authors in their research include Vishva M. Dixit, Kim Newton, Opher S. Kornfeld, Irma B. Stowe, and Joshua D. Webster. Kayagaki has collaborated extensively with these researchers, indicating a networked approach to their work.

The main publication venues for Kayagaki's research are:

  • Nature
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell
  • Nature Biotechnology
  • Science

Overall, Kayagaki's research contributions center on molecular mechanisms governing inflammation and immune response, with a significant focus on understanding cell death pathways and their implications for immune disorders.

Best Publications

  • Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

    Nobuhiko Kayagaki;Irma B. Stowe;Bettina L. Lee;Karen O’Rourke

  • Non-canonical inflammasome activation targets caspase-11

    Nobuhiko Kayagaki;Søren Warming;Mohamed Lamkanfi;Lieselotte Vande Walle

  • Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

    Nobuhiko Kayagaki;Michael T. Wong;Irma B. Stowe;Sree Ranjani Ramani

  • IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis.

    Eugene Varfolomeev;John W. Blankenship;Sarah M. Wayson;Anna V. Fedorova

  • Metalloproteinase-mediated release of human Fas ligand.

    N Kayagaki;A Kawasaki;T Ebata;H Ohmoto

  • Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death.

    Pontus Orning;Pontus Orning;Dan Weng;Dan Weng;Kristian Starheim;Kristian Starheim;Dmitry Ratner

  • Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells.

    Kazuyoshi Takeda;Yoshihiro Hayakawa;Mark J. Smyth;Nobuhiko Kayagaki

  • GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

    Robin A. Aglietti;Alberto Estevez;Aaron Gupta;Monica Gonzalez Ramirez

  • NINJ1 mediates plasma membrane rupture during lytic cell death

    Nobuhiko Kayagaki;Opher S. Kornfeld;Bettina L. Lee;Irma B. Stowe

  • Type I Interferons (IFNs) Regulate Tumor Necrosis Factor–related Apoptosis-inducing Ligand (TRAIL) Expression on Human T Cells: A Novel Mechanism for the Antitumor Effects of Type I IFNs

    Nobuhiko Kayagaki;Noriko Yamaguchi;Masafumi Nakayama;Hiroshi Eto

  • Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (Trail) Contributes to Interferon γ–Dependent Natural Killer Cell Protection from Tumor Metastasis

    Mark J. Smyth;Erika Cretney;Kazuyoshi Takeda;Robert H. Wiltrout

  • Critical Role for Tumor Necrosis Factor–related Apoptosis-inducing Ligand in Immune Surveillance Against Tumor Development

    Kazuyoshi Takeda;Mark J. Smyth;Erika Cretney;Yoshihiro Hayakawa

  • BAFF/BLyS Receptor 3 Binds the B Cell Survival Factor BAFF Ligand through a Discrete Surface Loop and Promotes Processing of NF-κB2

    Nobuhiko Kayagaki;Minhong Yan;Dhaya Seshasayee;Hua Wang

  • Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1

    Petr Broz;Thomas Ruby;Kamila Belhocine;Donna M. Bouley

  • Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis

    Jonathan W. Jones;Nobuhiko Kayagaki;Petr Broz;Thomas Henry

  • Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases

    Etienne Meunier;Mathias S. Dick;Roland F. Dreier;Nura Schürmann

  • DUBA: a deubiquitinase that regulates type I interferon production.

    Nobuhiko Kayagaki;Qui Phung;Salina Chan;Ruchir Chaudhari

  • Expression and function of TNF-related apoptosis-inducing ligand on murine activated NK cells.

    Nobuhiko Kayagaki;Noriko Yamaguchi;Masafumi Nakayama;Kazuyoshi Takeda

  • Antitumor effect of locally produced CD95 ligand

    Ken-Ichiro Seino;Nobuhiko Kayagaki;Ko Okumura;Hideo Yagita

  • Perforin, Fas/Fas ligand, and TNF-alpha pathways as specific and bystander killing mechanisms of hepatitis C virus-specific human CTL.

    K Ando;K Hiroishi;T Kaneko;T Moriyama

Frequent Co-Authors

Hideo Yagita
Hideo Yagita Juntendo University
Ko Okumura
Ko Okumura Juntendo University
Kazuyoshi Takeda
Kazuyoshi Takeda Juntendo University
Haruki Okamura
Haruki Okamura Hyogo College of Medicine
Hiroko Tsutsui
Hiroko Tsutsui Hyogo College of Medicine
Kenji Nakanishi
Kenji Nakanishi Hyogo College of Medicine
Mark J. Smyth
Mark J. Smyth QIMR Berghofer Medical Research Institute
Hisaya Akiba
Hisaya Akiba Juntendo University
Tetsuji Kobata
Tetsuji Kobata Tokyo Medical and Dental University
Toshikazu Shirai
Toshikazu Shirai Juntendo University

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