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Biology and Biochemistry

D-Index
56
Citations
12419
World Ranking
14340
National Ranking
1012

Overview

Yoshiyuki Horio is affiliated with Sapporo Medical University in Japan and has a substantial publication record centered on biological and medical research. Their work spans several fields, notably medicine and biochemistry, genetics, and molecular biology, with a particular focus on geriatrics and gerontology.

The scientist's research concentrates on key topics such as sirtuins and resveratrol in medicine, autophagy in disease and therapy, and adipose tissue and metabolism. Additional interests include biochemical effects in animals, chemotherapy-induced cardiotoxicity and its mitigation, muscle physiology and disorders, and mitochondrial function and pathology.

Among notable recent papers authored or co-authored by Yoshiyuki Horio are:

  • "Different Antioxidative and Antiapoptotic Effects of Piceatannol and Resveratrol" (2020, Journal of Pharmacology and Experimental Therapeutics)
  • "SIRT1 in the cardiomyocyte counteracts doxorubicin-induced cardiotoxicity via regulating histone H2AX" (2022, Cardiovascular Research)
  • "Resveratrol, a SIRT1 activator, attenuates aging-associated alterations in skeletal muscle and heart in mice" (2023, Journal of Pharmacological Sciences)
  • "Resveratrol improves motor function in patients with muscular dystrophies: an open-label, single-arm, phase IIa study" (2020, Scientific Reports)
  • "Downregulation of IGFBP5 contributes to replicative senescence via ERK2 activation in mouse embryonic fibroblasts" (2022, Aging)

Yoshiyuki Horio frequently publishes in venues including the Proceedings for Annual Meeting of The Japanese Pharmacological Society, Journal of Pharmacological Sciences, European Heart Journal, Journal of Pharmacology and Experimental Therapeutics, and Cardiovascular Research.

Collaboration is a significant aspect of their research. Frequent co-authors include Ryusuke Hosoda, Atsushi Kuno, Naotoshi Iwahara, Iyori Nojima, and Seidai Asakura.

Best Publications

  • Nucleocytoplasmic Shuttling of the NAD+-dependent Histone Deacetylase SIRT1

    Masaya Tanno;Jun Sakamoto;Tetsuji Miura;Kazuaki Shimamoto

  • A Novel Sulfonylurea Receptor Forms with BIR (Kir6.2) a Smooth Muscle Type ATP-sensitive K+ Channel

    Shojiro Isomoto;Chikako Kondo;Mitsuhiko Yamada;Shigeto Matsumoto

  • Immunogold evidence suggests that coupling of K+ siphoning and water transport in rat retinal Müller cells is mediated by a coenrichment of Kir4.1 and AQP4 in specific membrane domains

    Erlend A. Nagelhus;Yoshiyuki Horio;Atsushi Inanobe;Akikazu Fujita

  • Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea‐sensitive but ATP‐insensitive K+ channel.

    M Yamada;S Isomoto;S Matsumoto;C Kondo

  • Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome.

    Eugenia Morselli;Guillermo Mariño;Guillermo Mariño;Guillermo Mariño;Martin V. Bennetzen;Tobias Eisenberg

  • Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure.

    Masaya Tanno;Atsushi Kuno;Toshiyuki Yano;Tetsuji Miura

  • Regulation of FOXOs and p53 by SIRT1 Modulators under Oxidative Stress

    Yusuke S. Hori;Atsushi Kuno;Ryusuke Hosoda;Yoshiyuki Horio

  • SIRT1 is critical regulator of FOXO-mediated transcription in response to oxidative stress

    Yosuke Kobayashi;Yoko Furukawa-Hibi;Chen Chen;Yoshiyuki Horio

  • Expression cloning of a cDNA encoding the bovine histamine H1 receptor.

    Masakatsu Yamashita;Hiroyuki Fukui;Kazushige Sugama;Yoshiyuki Horio

  • Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation

    Shin Hisahara;Susumu Chiba;Hiroyuki Matsumoto;Masaya Tanno

  • A Novel ATP-dependent Inward Rectifier Potassium Channel Expressed Predominantly in Glial Cells

    Toru Takumi;Takahiro Ishii;Yoshiyuki Horio;Ken-Ichirou Morishige

  • Characterization of G-protein-gated K+ channels composed of Kir3.2 subunits in dopaminergic neurons of the substantia nigra

    Atsushi Inanobe;Yukiko Yoshimoto;Yoshiyuki Horio;Ken-Ichiro Morishige

  • Expression and Clustered Distribution of an Inwardly Rectifying Potassium Channel, KAB-2/Kir4.1, on Mammalian Retinal Müller Cell Membrane: Their Regulation by Insulin and Laminin Signals

    Masaru Ishii;Yoshiyuki Horio;Yoshihiko Tada;Hiroshi Hibino

  • Predominant expression of Sir2α, an NAD‐dependent histone deacetylase, in the embryonic mouse heart and brain1

    Jun Sakamoto;Tetsuji Miura;Kazuaki Shimamoto;Yoshiyuki Horio

  • An ATP-Dependent Inwardly Rectifying Potassium Channel, KAB-2 (Kir4.1), in Cochlear Stria Vascularis of Inner Ear: Its Specific Subcellular Localization and Correlation with the Formation of Endocochlear Potential

    Hiroshi Hibino;Yoshiyuki Horio;Atsushi Inanobe;Katsumi Doi

  • Resveratrol Ameliorates Muscular Pathology in the Dystrophic mdx Mouse, a Model for Duchenne Muscular Dystrophy

    Yusuke S Hori;Atsushi Kuno;Ryusuke Hosoda;Masaya Tanno

  • Plasma membrane fatty acid-binding protein and mitochondrial glutamic-oxaloacetic transaminase of rat liver are related

    P D Berk;H Wada;Y Horio;B J Potter

  • Molecular Cloning of the Human Histamine H1 Receptor Gene

    H. Fukui;K. Fujimoto;H. Mizuguchi;K. Sakamoto

  • Emerging beneficial roles of sirtuins in heart failure

    Masaya Tanno;Atsushi Kuno;Yoshiyuki Horio;Tetsuji Miura

  • Cellular and molecular effects of sirtuins in health and disease

    Yoshiyuki Horio;Takashi Hayashi;Atsushi Kuno;Risa Kunimoto

Frequent Co-Authors

Yoshihisa Kurachi
Yoshihisa Kurachi Osaka University
Kazuaki Shimamoto
Kazuaki Shimamoto Sapporo Medical University
Atsushi Kuno
Atsushi Kuno National Institute of Advanced Industrial Science and Technology
Seiji Ito
Seiji Ito Kansai Medical University
Hiroyuki Mizuguchi
Hiroyuki Mizuguchi Osaka University
Shun Shimohama
Shun Shimohama Sapporo Medical University
Yoshimi Takai
Yoshimi Takai Kobe University
Takeshi Kubo
Takeshi Kubo Osaka University
Toru Takumi
Toru Takumi Kobe University
Masakatsu Yamashita
Masakatsu Yamashita Ehime University

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