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Biology and Biochemistry

D-Index
59
Citations
17720
World Ranking
12320
National Ranking
950

Overview

Ian G. Charles is a researcher affiliated with the University of East Anglia in the United Kingdom. Their work spans several interconnected areas within biochemistry, genetics, molecular biology, and medicine, contributing to an array of studies in molecular biology, molecular medicine, endocrinology, genetics, and ecology.

The research topics they have covered include antibiotic resistance in bacteria, bacteriophages and microbial interactions, bacterial genetics and biotechnology, bacterial biofilms and quorum sensing, gut microbiota and health, Escherichia coli research studies, and SARS-CoV-2 and COVID-19 research.

Their frequent co-authors reflect collaborative efforts across various research fields. These include:

  • Mark Webber
  • Muhammad Yasir
  • A. Keith Turner
  • Andrew J. Page
  • Sarah Bastkowski

Most of Ian G. Charles's publications have appeared in a few key venues, indicating areas of concentrated research activity. These venues are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Microbial Genomics
  • Journal of Antimicrobial Chemotherapy
  • Scientific Reports
  • npj Parkinson s Disease

Some of their recent papers include:

  • "Meta-analysis of the Parkinson's disease gut microbiome suggests alterations linked to intestinal inflammation," 2021, npj Parkinson s Disease
  • "CoronaHiT: high-throughput sequencing of SARS-CoV-2 genomes," 2021, Genome Medicine
  • "TraDIS-Xpress: a high-resolution whole-genome assay identifies novel mechanisms of triclosan action and resistance," 2020, Genome Research
  • "Large-scale sequencing of SARS-CoV-2 genomes from one region allows detailed epidemiology and enables local outbreak management," 2021, Microbial Genomics
  • "Genomic comparisons of Escherichia coli ST131 from Australia," 2021, Microbial Genomics

The volume and diversity of research carried out by Ian G. Charles indicate a focus on molecular and microbial biology that interfaces with public health and disease mechanisms. Their work on antibiotic resistance and bacterial genetics addresses ongoing challenges in microbiology, while studies on the gut microbiome and viral genomics reflect engagement with emerging biomedical topics.

Best Publications

  • Altered immune responses in mice lacking inducible nitric oxide synthase

    Xiao-Qing Wei;Ian G. Charles;Austin Smith;Jan Ure

  • Induction of calcium-dependent nitric oxide synthases by sex hormones

    Carl P. Weiner;Ignacio Lizasoain;Sally A. Baylis;Richard G. Knowles

  • Roles of nitric oxide in tumor growth

    D C Jenkins;I G Charles;L L Thomsen;D W Moss

  • The role of nitric oxide in cancer.

    Weiming Xu;Li Zhi Liu;Marilena Loizidou;Mohamed Ahmed

  • Simultaneous assay of every Salmonella Typhi gene using one million transposon mutants

    Gemma C. Langridge;Minh Duy Phan;Daniel J. Turner;Timothy T. Perkins

  • Explosive cell lysis as a mechanism for the biogenesis of bacterial membrane vesicles and biofilms

    Lynne Turnbull;Masanori Toyofuku;Masanori Toyofuku;Amelia L. Hynen;Masaharu Kurosawa

  • Meta-analysis of the Parkinson's disease gut microbiome suggests alterations linked to intestinal inflammation.

    Stefano Romano;George M. Savva;Janis R. Bedarf;Janis R. Bedarf;Ian G. Charles;Ian G. Charles

  • Cloning, characterization, and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte

    Ian G. Charles;Richard M. J. Palmer;Mark S. Hickery;Michael T. Bayliss

  • Structure of Bordetella pertussis virulence factor P.69 pertactin.

    Paul Emsley;Ian G. Charles;Neil F. Fairweather;Neil W. Isaacs

  • Pertactin, an Arg-Gly-Asp-containing Bordetella pertussis surface protein that promotes adherence of mammalian cells

    Elizabeth Leininger;Mark Roberts;James G. Kenimer;Ian G. Charles

  • Comprehensive identification of essential Staphylococcus aureus genes using Transposon-Mediated Differential Hybridisation (TMDH)

    Roy Ronjon Chaudhuri;Andrew G Allen;Paul J Owen;Gil Shalom

  • The role of a stress‐response protein in Salmonella typhimurium virulence

    K. Johnson;I. Charles;G. Dougan;D. Pickard

  • Self-organization of bacterial biofilms is facilitated by extracellular DNA.

    Erin S. Gloag;Lynne Turnbull;Alan Huang;Pascal Vallotton

  • Use of the nirB promoter to direct the stable expression of heterologous antigens in Salmonella oral vaccine strains: development of a single-dose oral tetanus vaccine.

    S. N. Chatfield;I. G. Charles;A. J. Makoff;M. D. Oxer

  • A lethal role for lipid A in Salmonella infections

    Shahid A. Khan;Paul Everest;Spiros Servos;Neale Foxwell

  • Comprehensive assignment of roles for Salmonella typhimurium genes in intestinal colonization of food-producing animals.

    Roy R. Chaudhuri;Eirwen Morgan;Sarah E. Peters;Stephen J. Pleasance

  • Genotyping and functional analysis of a polymorphic (CCTTT)n repeat of NOS2A in diabetic retinopathy

    K. M. Warpeha;W. Xu;L. Liu;I. G. Charles

  • Evaluation of Salmonella typhimurium strains harbouring defined mutations in htrA and aroA in the murine salmonellosis model.

    Steven N. Chatfield;Karen Strahan;Derek Pickard;Ian G. Charles

  • Nitric oxide induces coupling of mitochondrial signalling with the endoplasmic reticulum stress response.

    Weiming Xu;Lizhi Liu;Ian G. Charles;Salvador Moncada

  • The structures of the H(C) fragment of tetanus toxin with carbohydrate subunit complexes provide insight into ganglioside binding.

    Paul Emsley;Constantina Fotinou;Isobel Black;Neil F. Fairweather

Frequent Co-Authors

Mark A. Webber
Mark A. Webber University of East Anglia
David K. Stammers
David K. Stammers University of Oxford
Neil F. Fairweather
Neil F. Fairweather Imperial College London
Steven P. Djordjevic
Steven P. Djordjevic University of Technology Sydney
Gordon Dougan
Gordon Dougan University of Cambridge
John Wain
John Wain University of East Anglia
Duncan J. Maskell
Duncan J. Maskell University of Melbourne
Salvador Moncada
Salvador Moncada University of Manchester
Alison E. Mather
Alison E. Mather Norwich University
Jingshan Ren
Jingshan Ren University of Oxford

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