World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
82
Citations
21097
World Ranking
16281
National Ranking
8185

Overview

Jacob E. Friedman is affiliated with the University of Oklahoma Health Sciences Center in the United States. Their research spans multiple disciplines primarily within medicine and biochemistry, genetics, and molecular biology. With a significant focus on Pediatrics, Perinatology and Child Health, and Obstetrics and Gynecology, their work addresses critical aspects of early human development and maternal-fetal health.

Their recent publications reflect diverse interests related to pregnancy, gestational diabetes, diabetes management, and infant health. Key papers include:

  • The importance of nutrition in pregnancy and lactation: lifelong consequences (2021) published in American Journal of Obstetrics and Gynecology
  • A review of jet impingement cooling (2023) published in International Journal of Thermofluids
  • Gestational Diabetes Is Uniquely Associated With Altered Early Seeding of the Infant Gut Microbiota (2020) published in Frontiers in Endocrinology
  • Type 2 Diabetes in Youth: the Role of Early Life Exposures (2020) published in Current Diabetes Reports
  • A maternal higher-complex carbohydrate diet increases bifidobacteria and alters early life acquisition of the infant microbiome in women with gestational diabetes mellitus (2022) published in Frontiers in Endocrinology

The scientist has collaborated frequently with other researchers in their field, among them Stephanie R. Wesolowski, Kjersti M. Aagaard, Linda A. Barbour, Teri L. Hernandez, and Paul Kievit. These collaborations have contributed to a broad and interdisciplinary approach to their research topics.

Their work has appeared predominantly in journals and publication venues such as:

  • Diabetes
  • Frontiers in Endocrinology
  • American Journal of Obstetrics and Gynecology
  • Neuropsychopharmacology
  • Journal of Medicinal Chemistry

The main fields of study encompass Medicine, with 52 publications, and Biochemistry, Genetics and Molecular Biology, with 18 publications. Subfields of focus include:

  • Pediatrics, Perinatology and Child Health
  • Obstetrics and Gynecology
  • Molecular Biology
  • Surgery
  • Genetics

The thematic concentration in their research can be summarized through key topics:

  • Birth, Development, and Health
  • Gestational Diabetes Research and Management
  • Pregnancy and preeclampsia studies
  • Receptor Mechanisms and Signaling
  • Pancreatic function and diabetes
  • Diet and metabolism studies
  • Gut microbiota and health

Best Publications

  • TNF-α Is a Predictor of Insulin Resistance in Human Pregnancy

    John P. Kirwan;Sylvie Hauguel-De Mouzon;Jacques Lepercq;Jean-Claude Challier

  • Cellular Mechanisms for Insulin Resistance in Normal Pregnancy and Gestational Diabetes

    Linda A. Barbour;Carrie E. McCurdy;Teri L. Hernandez;John P. Kirwan

  • Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates

    Carrie E. McCurdy;Jacalyn M. Bishop;Sarah M. Williams;Bernadette E. Grayson

  • Maternal obesity and fetal metabolic programming: a fertile epigenetic soil

    Margaret J. R. Heerwagen;Melissa R. Miller;Linda A. Barbour;Jacob E. Friedman

  • Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation.

    Agnieszka A. Kendrick;Mahua Choudhury;Shaikh M. Rahman;Carrie E. McCurdy

  • Longitudinal changes in maternal serum leptin concentrations, body composition, and resting metabolic rate in pregnancy

    Timothy J. Highman;Jacob E. Friedman;Larraine P. Huston;William W. Wong

  • Insulin responsiveness in skeletal muscle is determined by glucose transporter (Glut4) protein level.

    M Kern;J A Wells;J M Stephens;C W Elton

  • Impaired glucose transport and insulin receptor tyrosine phosphorylation in skeletal muscle from obese women with gestational diabetes.

    Jacob E. Friedman;Tatsuya Ishizuka;Jianhua Shao;Larraine Huston

  • Hepatitis C virus infection: molecular pathways to metabolic syndrome.

    Muhammad Y. Sheikh;Jinah Choi;Ishtiaq Qadri;Jacob E. Friedman

  • Downregulated IRS-1 and PPARγ in obese women with gestational diabetes: relationship to FFA during pregnancy

    Patrick M. Catalano;Steven E. Nizielski;Jianhua Shao;Larraine Preston

  • The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD.

    Taylor K. Soderborg;Sarah E. Clark;Christopher E. Mulligan;Rachel C. Janssen

  • Human placental growth hormone causes severe insulin resistance in transgenic mice.

    Linda A. Barbour;Jianhua Shao;Liping Qiao;Leslie K. Pulawa

  • Human placental growth hormone increases expression of the p85 regulatory unit of phosphatidylinositol 3-kinase and triggers severe insulin resistance in skeletal muscle.

    Linda A. Barbour;Jianhua Shao;Liping Qiao;Wayne Leitner

  • Restoration of insulin responsiveness in skeletal muscle of morbidly obese patients after weight loss. Effect on muscle glucose transport and glucose transporter GLUT4.

    J E Friedman;G L Dohm;N Leggett-Frazier;C W Elton

  • Exercise training increases glucose transporter protein GLUT-4 in skeletal muscle of obese Zucker (fa/fa) rats.

    Jacob E. Friedman;William M. Sherman;Michael J. Reed;Charles W. Eiton

  • Elevated skeletal muscle glucose transporter levels in exercise-trained middle-aged men.

    J. A. Houmard;P. C. Egan;P. D. Neufer;J. E. Friedman

  • Phosphoenolpyruvate carboxykinase overexpression selectively attenuates insulin signaling and hepatic insulin sensitivity in transgenic mice.

    Yang Sun;Sha Liu;Sandra Ferguson;LiQin Wang

  • C/EBP transcription factors regulate SREBP1c gene expression during adipogenesis.

    Victoria A. Payne;Wo‑Shing Au;Christopher E. Lowe;Shaikh M. Rahman

  • Adventitial Fibroblasts Induce a Distinct Proinflammatory/Profibrotic Macrophage Phenotype in Pulmonary Hypertension

    Karim C. El Kasmi;Steven C. Pugliese;Suzette R. Riddle;Jens M. Poth

  • TNF- Is a Predictor of Insulin Resistance in Human

    Pregnancy P. Kirwan;Sylvie Hauguel-De Mouzon;Jacques Lepercq;Jean-Claude Challier

Frequent Co-Authors

Nancy F. Krebs
Nancy F. Krebs University of Colorado Denver
Dana Dabelea
Dana Dabelea University of Colorado Anschutz Medical Campus
Patrick M. Catalano
Patrick M. Catalano Case Western Reserve University
Daniel N. Frank
Daniel N. Frank University of Colorado Anschutz Medical Campus
Charles E. Robertson
Charles E. Robertson University of Colorado Anschutz Medical Campus
Ivana V. Yang
Ivana V. Yang University of Colorado Denver
David J. Orlicky
David J. Orlicky University of Colorado Denver
Richard W. Hanson
Richard W. Hanson Case Western Reserve University
Angelo D'Alessandro
Angelo D'Alessandro University of Colorado Denver
Moshe Levi
Moshe Levi Georgetown University

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