World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
57
Citations
15260
World Ranking
13631
National Ranking
516

Overview

Germain Trugnan is affiliated with Grenoble Alpes University in France. Their research spans several fields, predominantly within biochemistry, genetics, and molecular biology, with additional focus on medicine.

The primary areas of study include molecular biology, pulmonary and respiratory medicine, infectious diseases, neurology, and sensory systems. Trugnan's work engages with diverse topics such as respiratory support and mechanisms, COVID-19 clinical research studies, long-term effects of COVID-19, genomics, phytochemicals, oxidative stress, signaling pathways in disease, ion channels and receptors, and genetic and kidney cyst diseases.

The scientist has published papers in a number of notable venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory) with two publications
  • Scientific Reports with one publication

Recent publications showcase the scope of their research:

  • Identification of bronchoalveolar and blood immune-inflammatory biomarker signature associated with poor 28-day outcome in critically ill COVID-19 patients (2022, Scientific Reports)
  • A receptor-independent signaling pathway for BDNF (2022, bioRxiv, Cold Spring Harbor Laboratory)
  • Sterols regulate ciliary membrane dynamics and hedgehog signaling in health and disease (2025, bioRxiv, Cold Spring Harbor Laboratory)

Trugnan collaborates frequently with a group of coauthors, notable among them are:

  • Thibaut Eguether
  • Antonin Lamazière
  • Guillaume Voiriot
  • Karim Dorgham
  • Guillaume Bachelot

The breadth of their research covers critical mechanisms within cellular biology and disease, including signaling pathways and immune-inflammatory responses. Their involvement in COVID-19 clinical studies and investigations into long-term effects emphasizes contributions to current medical challenges in respiratory and infectious disease domains.

Through multidisciplinary investigation and collaboration, Germain Trugnan's work integrates biochemistry and molecular biology approaches to better understand disease processes, particularly in pulmonary function and neurological signaling.

Best Publications

  • Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients

    Harry Sokol;Bénédicte Pigneur;Laurie Watterlot;Omar Lakhdari

  • Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases

    Henri Duboc;Sylvie Rajca;Sylvie Rajca;Dominique Rainteau;Dominique Rainteau;David Benarous

  • Identification of an anti-inflammatory protein from Faecalibacterium prausnitzii, a commensal bacterium deficient in Crohn’s disease

    E. Quévrain;M.A. Maubert;C. Michon;F. Chain;F. Chain

  • Expression of the molecular chaperone Hsp70 in detergent-resistant microdomains correlates with its membrane delivery and release.

    Alexis H. Broquet;Ginette Thomas;Joëlle Masliah;Germain Trugnan

  • Dipeptidyl peptidase IV (CD 26) gene expression in enterocyte-like colon cancer cell lines HT-29 and Caco-2. Cloning of the complete human coding sequence and changes of dipeptidyl peptidase IV mRNA levels during cell differentiation.

    D Darmoul;M Lacasa;L Baricault;D Marguet

  • Rotaviruses Associate with Cellular Lipid Droplet Components To Replicate in Viroplasms, and Compounds Disrupting or Blocking Lipid Droplets Inhibit Viroplasm Formation and Viral Replication

    Winsome Cheung;Michael Gill;Alessandro Esposito;Clemens F. Kaminski

  • Matrix Metalloproteinases MMP2 and MMP9 Are Produced in Early Stages of Kidney Morphogenesis but Only MMP9 Is Required for Renal Organogenesis In Vitro

    Brigitte Lelongt;Germain Trugnan;Gillian Murphy;Pierre M. Ronco

  • The intracellular accumulation of UDP-N-acetylhexosamines is concomitant with the inability of human colon cancer cells to differentiate.

    B. M. Wice;G. Trugnan;M. Pinto;Monique Rousset

  • Rotavirus is released from the apical surface of cultured human intestinal cells through nonconventional vesicular transport that bypasses the Golgi apparatus.

    N Jourdan;M Maurice;D Delautier;A M Quero

  • Enterocytic differentiation and glucose utilization in the human colon tumor cell line Caco-2: modulation by forskolin.

    Monique Rousset;Marc Laburthe;Moïse Pinto;Guillemette Chevalier

  • Bile acid profiling in human biological samples: comparison of extraction procedures and application to normal and cholestatic patients.

    Lydie Humbert;Marie Anne Maubert;Claude Wolf;Henri Duboc

  • Individual Rotavirus-like Particles Containing 120 Molecules of Fluorescent Protein Are Visible in Living Cells

    Annie Charpilienne;Mohamed Nejmeddine;Mohamed Nejmeddine;Mabel Berois;Nathalie Parez

  • Galectin-4-regulated delivery of glycoproteins to the brush border membrane of enterocyte-like cells.

    Laurence Stechly;Willy Morelle;Anne-Frédérique Dessein;Sabine André

  • Raft-mediated trafficking of apical resident proteins occurs in both direct and transcytotic pathways in polarized hepatic cells: role of distinct lipid microdomains.

    Tounsia Aït Slimane;Germain Trugnan;Sven C.D. van IJzendoorn;Dick Hoekstra

  • Rotavirus Infection Reduces Sucrase-Isomaltase Expression in Human Intestinal Epithelial Cells by Perturbing Protein Targeting and Organization of Microvillar Cytoskeleton

    Nathalie Jourdan;Jean Philippe Brunet;Catherine Sapin;Anne Blais

  • Rotavirus NSP4 induces a novel vesicular compartment regulated by calcium and associated with viroplasms.

    Z. Berkova;S. E. Crawford;G. Trugnan;T. Yoshimori

  • Interplay between bile acid metabolism and microbiota in irritable bowel syndrome

    M. Dior;H. Delagrèverie;H. Duboc;P. Jouet

  • Detergents induce raft-like domains budding and fission from giant unilamellar heterogeneous vesicles: a direct microscopy observation.

    Galya Staneva;Michel Seigneuret;Kamen Koumanov;Germain Trugnan

  • Hypoxia Enhances Ecto-5′-Nucleotidase Activity and Cell Surface Expression in Endothelial Cells Role of Membrane Lipids

    S. Ledoux;I. Runembert;K. Koumanov;J.B. Michel

  • The posttranslational processing of sucrase-isomaltase in HT-29 cells is a function of their state of enterocytic differentiation.

    Germain Trugnan;Monique Rousset;Isabelle Chantret;Alain Barbat

Frequent Co-Authors

Harry Sokol
Harry Sokol Sorbonne University
Gérard Chassaing
Gérard Chassaing Université Paris Cité
Patrice Codogno
Patrice Codogno Université Paris Cité
Solange Lavielle
Solange Lavielle PSL University
Philippe Langella
Philippe Langella University of Paris-Saclay
James W. Goding
James W. Goding Monash University
Luis G. Bermúdez-Humarán
Luis G. Bermúdez-Humarán University of Paris-Saclay
Jean Cohen
Jean Cohen INRAE : Institut national de recherche pour l'agriculture, l'alimentation et l'environnement
Pierre-Yves Boëlle
Pierre-Yves Boëlle Sorbonne University

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Related Online Degrees & Career Pathways

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Exploring these educational and career pathways can diversify opportunities for Biology and Biochemistry graduates, both in and beyond the laboratory.

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