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Charles E. Smith

Charles E. Smith

D-Index & Metrics

Biology and Biochemistry

D-Index
52
Citations
8555
World Ranking
16799
National Ranking
594

Overview

Charles E. Smith is a researcher affiliated with McGill University in Canada. Their academic focus spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with notable work in several specialized subfields including Molecular Biology and Rheumatology. They have contributed to research on Oral Surgery, Urology, and Physiology as well.

The scientist's research topics cover a range of subjects, primarily centered on bone and dental protein studies as well as dental development and anomalies. Other areas of investigation include Oral and Maxillofacial Pathology, Periodontal Regeneration and Treatments, Obstructive Sleep Apnea Research, Gut microbiota and health, and Chronic Obstructive Pulmonary Disease (COPD) Research.

Key recent publications include:

  • MMP20-generated amelogenin cleavage products prevent formation of fan-shaped enamel malformations (2021, Scientific Reports)
  • Obstructive Sleep Apnea as a Risk Factor for COVID-19 Severity-The Gut Microbiome as a Common Player Mediating Systemic Inflammation via Gut Barrier Dysfunction (2022, Cells)
  • Dentin defects caused by a Dspp−1 frameshift mutation are associated with the activation of autophagy (2023, Scientific Reports)
  • Localizations of Laminin Chains Suggest Their Multifaceted Functions in Mouse Tooth Development (2025, International Journal of Molecular Sciences)
  • Citrate Transporter Expression and Localization: The Slc13a5Flag Mouse Model (2025, International Journal of Molecular Sciences)

Charles E. Smith frequently publishes in several academic venues, with multiple contributions to Scientific Reports and the International Journal of Molecular Sciences. Other publications have appeared in Cells, Equine Veterinary Education, and the Journal of Anatomy.

The scientist collaborates regularly with peers, including frequent coauthors such as James P. Simmer, Tian Liang, Jan C.-C. Hu, Chuhua Zhang, and John D. Bartlett.

Best Publications

  • Endocrine regulation of male fertility by the skeleton

    Franck Oury;Grzegorz Sumara;Olga Sumara;Mathieu Ferron

  • Morphological classification of rat incisor ameloblasts.

    H. Warshawsky;C. E. Smith

  • Surfing the wave, cycle, life history, and genes/proteins expressed by testicular germ cells. Part 1: Background to spermatogenesis, spermatogonia, and spermatocytes

    Louis Hermo;R.-Marc Pelletier;Daniel G. Cyr;Charles E. Smith

  • Regulation of Dental Enamel Shape and Hardness

    J.P. Simmer;P. Papagerakis;C.E. Smith;D.C. Fisher

  • Surfing the wave, cycle, life history, and genes/proteins expressed by testicular germ cells. Part 3: developmental changes in spermatid flagellum and cytoplasmic droplet and interaction of sperm with the zona pellucida and egg plasma membrane.

    Louis Hermo;R.-Marc Pelletier;Daniel G. Cyr;Charles E. Smith

  • Enamel defects and ameloblast-specific expression in Enam knock-out/lacZ knock-in mice

    Jan C.-C. Hu;Yuanyuan Hu;Charles E. Smith;Marc D. McKee

  • Surfing the wave, cycle, life history, and genes/proteins expressed by testicular germ cells. Part 2: Changes in spermatid organelles associated with development of spermatozoa

    Louis Hermo;R.-Marc Pelletier;Daniel G. Cyr;Charles E. Smith

  • Quantitative analysis of cell turnover in the enamel organ of the rat incisor. Evidence for ameloblast death immediately after enamel matrix secretion.

    C. E. Smith;H. Warshawsky

  • A method for sampling the stages of amelogenesis on mandibular rat incisors using the molars as a reference for dissection.

    C. E. Smith;A. Nanci

  • Cloning of rat amelotin and localization of the protein to the basal lamina of maturation stage ameloblasts and junctional epithelium.

    Pierre Moffatt;Charles E. Smith;René St-Arnaud;Darrin Simmons

  • Degradation and loss of matrix proteins from developing enamel.

    C. E. Smith;J. R. Pompura;S. Borenstein;A. Fazel

  • Comparative Immunochemical Analyses of the Developmental Expression and Distribution of Ameloblastin and Amelogenin in Rat Incisors

    A. Nanci;S. Zalzal;P. Lavoie;M. Kunikata

  • Ameloblasts: Secretory and Resorptive Functions

    C.E. Smith

  • Decreased Mineral Content in MMP-20 Null Mouse Enamel is Prominent During the Maturation Stage

    J.D. Bartlett;E. Beniash;D.H. Lee;C.E. Smith

  • A post-classical theory of enamel biomineralization… and why we need one

    James P. Simmer;Amelia S. Richardson;Yuan Yuan Hu;Charles E. Smith

  • Characterization of Apin, a secreted protein highly expressed in tooth-associated epithelia.

    Pierre Moffatt;Charles E. Smith;René St-Arnaud;René St-Arnaud;Antonio Nanci

  • Immunocytochemical and radioautographic evidence for secretion and intracellular degradation of enamel proteins by ameloblasts during the maturation stage of amelogenesis in rat incisors.

    Antonio Nanci;Harold C. Slavkin;Charles E. Smith

  • Movement of entire cell populations during renewal of the rat incisor as shown by radoioautography after labeling with 3H-thymidine. The concept of a continuously differentiating cross-sectional segment. (With an appendix on the development of the periodontal ligament).

    C. E. Smith;H. Warshawsky

  • Cyclic Induction and Rapid Movement of Sequential Waves of New Smooth-Ended Ameloblast Modulation Bands in Rat Incisors as Visualized By Polychrome Fluorescent Labeling and Gbha-Staining of Maturing Enamel

    C.E. Smith;M.D. McKee;A. Nanci

  • Protein dynamics of amelogenesis.

    Charles E. Smith;Antonio Nanci

Frequent Co-Authors

Louis Hermo
Louis Hermo McGill University
James P. Simmer
James P. Simmer University of Michigan–Ann Arbor
Antonio Nanci
Antonio Nanci University of Montreal
Daniel G. Cyr
Daniel G. Cyr University of Quebec
Jan C.-C. Hu
Jan C.-C. Hu University of Michigan–Ann Arbor
John D. Bartlett
John D. Bartlett The Ohio State University
John J. M. Bergeron
John J. M. Bergeron McGill University
Marc D. McKee
Marc D. McKee McGill University
Ira Kurtz
Ira Kurtz University of California, Los Angeles
René St-Arnaud
René St-Arnaud Shriners Hospitals for Children - Erie

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