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Medicine

D-Index
97
Citations
33923
World Ranking
9302
National Ranking
4799

Overview

John C. Crabbe is affiliated with Oregon Health & Science University in the United States and focuses on research in the fields of neuroscience, medicine, and biochemistry, genetics, and molecular biology. Their work spans several subfields including cellular and molecular neuroscience, molecular biology, biological psychiatry, physiology, and pathology and forensic medicine.

The primary topics of Crabbe's research include neurotransmitter receptor influence on behavior, tryptophan and brain disorders, receptor mechanisms and signaling, alcohol consumption and health effects, stress responses and cortisol, biochemical analysis and sensing techniques, and adipose tissue and metabolism.

Crabbe has coauthored publications with Pamela Metten, Angela R. Ozburn, Antonia M. Savarese, Kolter B. Grigsby, and Evan J. Firsick, reflecting repeated collaborations on related research projects. Frequent publication venues for Crabbe's work include bioRxiv (Cold Spring Harbor Laboratory), Addiction Biology, Journal of Clinical Investigation, Alcoholism Clinical and Experimental Research, and Alcohol.

Among Crabbe's recent papers are the following:

  • Preclinical and clinical evidence for suppression of alcohol intake by apremilast (2023) in Journal of Clinical Investigation
  • Targeting the Glucocorticoid Receptor Reduces Binge-Like Drinking in High Drinking in the Dark (HDID-1) Mice (2020) in Alcoholism Clinical and Experimental Research
  • The impact of Drinking in the Dark (DID) procedural manipulations on ethanol intake in High Drinking in the Dark (HDID) mice (2021) in Alcohol
  • Ethanol-Related Behaviors in Mouse Lines Selectively Bred for Drinking to Intoxication (2021) in Brain Sciences
  • Tetracycline derivatives reduce binge alcohol consumption in High Drinking in the Dark mice (2020) in Brain Behavior & Immunity - Health

Best Publications

  • Genetics of mouse behavior: interactions with laboratory environment.

    John C. Crabbe;Douglas Wahlsten;Bruce C. Dudek

  • Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies.

    Jacqueline N. Crawley;John K. Belknap;Allan Collins;John C. Crabbe

  • The Collaborative Cross, a community resource for the genetic analysis of complex traits

    Gary A. Churchill;David C. Airey;Hooman Allayee;Joe M. Angel

  • Evaluation of a simple model of ethanol drinking to intoxication in C57BL/6J mice.

    Justin S. Rhodes;Karyn Best;John K. Belknap;Deborah A. Finn

  • Voluntary consumption of ethanol in 15 inbred mouse strains

    John K. Belknap;John C. Crabbe;E. R. Young

  • Different data from different labs: lessons from studies of gene-environment interaction.

    Douglas Wahlsten;Pamela Metten;Tamara J. Phillips;Stephen L. Boehm

  • Genetic animal models of alcohol and drug abuse

    John C. Crabbe;John K. Belknap;Kari J. Buck

  • The nature and identification of quantitative trait loci: a community's view.

    Oduola Abiola;Joe M. Angel;Philip Avner;Alexander A. Bachmanov

  • Acute withdrawal, protracted abstinence and negative affect in alcoholism: Are they linked?

    Markus Heilig;Mark Egli;John C. Crabbe;Howard C. Becker

  • Elevated alcohol consumption in null mutant mice lacking 5-HT1B serotonin receptors

    John C. Crabbe;Tamara J. Phillips;Daniel J. Feller;René Hen

  • Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor.

    Beatriz A. Rocha;Kimberly Scearce-Levie;José J. Lucas;José J. Lucas;Noboru Hiroi;Noboru Hiroi

  • Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis.

    Megan K. Mulligan;Igor Ponomarev;Robert J. Hitzemann;John K. Belknap

  • Mouse inbred strain differences in ethanol drinking to intoxication

    J. S. Rhodes;M. M. Ford;C. H. Yu;L. L. Brown

  • Estimation of Genetic Correlation: Interpretation of Experiments Using Selectively Bred and Inbred Animals

    John C. Crabbe;Tamara J. Phillips;Ann Kosobud;John K. Belknap

  • Quantitative Trait Loci Involved in Genetic Predisposition to Acute Alcohol Withdrawal in Mice

    Kari Johnson Buck;Pamela Metten;John K. Belknap;John K. Belknap;John C. Crabbe;John C. Crabbe

  • Genetic Contributions to Addiction

    John C. Crabbe

  • Localization of genes affecting alcohol drinking in mice.

    Tamara J. Phillips;John C. Crabbe;Pamela Metten;John K. Belknap

  • Stability of inbred mouse strain differences in behavior and brain size between laboratories and across decades

    Douglas Wahlsten;Alexander Bachmanov;Deborah A. Finn;John C. Crabbe

  • Increased drinking during withdrawal from intermittent ethanol exposure is blocked by the CRF receptor antagonist D-Phe-CRF(12-41).

    Deborah A. Finn;Deborah A. Finn;Christopher Snelling;Andrea M. Fretwell;Michelle A. Tanchuck

  • Identifying genes for alcohol and drug sensitivity: recent progress and future directions.

    John C. Crabbe;Tamara J. Phillips;Kari J. Buck;Christopher L. Cunningham

Frequent Co-Authors

John K. Belknap
John K. Belknap Oregon Health & Science University
Deborah A. Finn
Deborah A. Finn Oregon Health & Science University
Tamara J. Phillips
Tamara J. Phillips Oregon Health & Science University
R. Adron Harris
R. Adron Harris The University of Texas at Austin
Justin S. Rhodes
Justin S. Rhodes University of Illinois at Urbana-Champaign
Amanda J. Roberts
Amanda J. Roberts Scripps Research Institute
Shannon K. McWeeney
Shannon K. McWeeney Oregon Health & Science University
Robert W. Williams
Robert W. Williams University of Tennessee Health Science Center
Robert Plomin
Robert Plomin King's College London
Elissa J. Chesler
Elissa J. Chesler University of Tennessee at Knoxville

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