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Biology and Biochemistry

D-Index
62
Citations
10740
World Ranking
11026
National Ranking
4766

Overview

Mei Chen is affiliated with the University of Southern California in the United States. Their research spans across the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a particular focus on Molecular Biology, Cell Biology, Cancer Research, Oncology, and Pulmonary and Respiratory Medicine.

The scientist has contributed extensively to topics including Skin and Cellular Biology Research, Autoimmune Bullous Skin Diseases, Cancer-related Molecular Mechanisms Research, Cancer Immunotherapy and Biomarkers, Cellular Mechanics and Interactions, Extracellular Vesicles in Disease, and Ferroptosis and Cancer Prognosis.

Mei Chen has authored and co-authored numerous papers published in a range of scientific journals. Some notable publications include:

  • Targeted, efficient sequence insertion and replacement in rice, 2020, Nature Biotechnology
  • Exosomal microRNA-146a derived from mesenchymal stem cells increases the sensitivity of ovarian cancer cells to docetaxel and taxane via a LAMC2-mediated PI3K/Akt axis, 2020, International Journal of Molecular Medicine
  • KMT2C deficiency promotes small cell lung cancer metastasis through DNMT3A-mediated epigenetic reprogramming, 2022, Nature Cancer
  • Curcumin Represses Colorectal Cancer Cell Proliferation by Triggering Ferroptosis via PI3K/Akt/mTOR Signaling, 2022, Nutrition and Cancer
  • Assessment of separation methods for extracellular vesicles from human and mouse brain tissues and human cerebrospinal fluids, 2020, Methods

Their frequent co-authors include David T. Woodley, Wei Li, Xin Tang, Michelle Hao, and Jon Cogan, indicating a collaborative research network.

Mei Chen has published extensively in several venues, with the highest number of publications appearing in:

  • Journal of Investigative Dermatology
  • Frontiers in Oncology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Clinical Oncology
  • Cells

Their work primarily explores mechanisms underlying cancer progression, cellular biology, and molecular approaches to disease, with a notable contribution to research on ferroptosis and extracellular vesicles in disease contexts.

Best Publications

  • Epitope spreading : Lessons from autoimmune skin diseases

    Lawrence S. Chan;Carol J. Vanderlugt;Takashi Hashimoto;Takeji Nishikawa

  • Bone Marrow Transplantation for Recessive Dystrophic Epidermolysis Bullosa

    John E Wagner;Akemi Ishida-Yamamoto;John A McGrath;Maria Hordinsky

  • TANGO1 facilitates cargo loading at endoplasmic reticulum exit sites.

    Kota Saito;Mei Chen;Fred Bard;Shenghong Chen

  • Extracellular heat shock protein-90α: linking hypoxia to skin cell motility and wound healing.

    Wei Li;Wei Li;Yong Li;Yong Li;Yong Li;Shengxi Guan;Jianhua Fan;Jianhua Fan

  • Restoration of type VII collagen expression and function in dystrophic epidermolysis bullosa.

    Mei Chen;Noriyuki Kasahara;Douglas R Keene;Lawrence Chan

  • Transforming Growth Factor α (TGFα)-Stimulated Secretion of HSP90α: Using the Receptor LRP-1/CD91 To Promote Human Skin Cell Migration against a TGFβ-Rich Environment during Wound Healing

    Chieh-Fang Cheng;Jianhua Fan;Mark Fedesco;Shengxi Guan

  • Interactions of the Amino-terminal Noncollagenous (NC1) Domain of Type VII Collagen with Extracellular Matrix Components A POTENTIAL ROLE IN EPIDERMAL-DERMAL ADHERENCE IN HUMAN SKIN

    Mei Chen;M. Peter Marinkovich;Arthur Veis;Xiaoyan Cai

  • Mechanism of Human Dermal Fibroblast Migration Driven by Type I Collagen and Platelet-derived Growth Factor-BB

    Wei Li;Jianhua Fan;Mei Chen;Shengxi Guan

  • A “traffic control” role for TGFβ3: orchestrating dermal and epidermal cell motility during wound healing

    Balaji Bandyopadhyay;Jianhua Fan;Shengxi Guan;Yong Li

  • Development of an ELISA for Rapid Detection of Anti-Type VII Collagen Autoantibodies in Epidermolysis Bullosa Acquisita

    Mei Chen;Lawrence S. Chan;Xiaoyan Cai;Edel A. O'Toole

  • Epidermolysis bullosa acquisita

    Rishu Gupta;David T. Woodley;Mei Chen

  • Injection of recombinant human type VII collagen restores collagen function in dystrophic epidermolysis bullosa

    David T Woodley;Douglas R Keene;Tom Atha;Yi Huang

  • Injection of recombinant human type VII collagen corrects the disease phenotype in a murine model of dystrophic epidermolysis bullosa.

    Jennifer Remington;Xinyi Wang;Xinyi Wang;Yingpin Hou;Hui Zhou

  • Normal and gene-corrected dystrophic epidermolysis bullosa fibroblasts alone can produce type VII collagen at the basement membrane zone.

    David T. Woodley;Gerald G. Krueger;Cynthia M. Jorgensen;Janet A. Fairley

  • Bullous systemic lupus erythematosus with autoantibodies recognizing multiple skin basement membrane components, bullous pemphigoid antigen 1, laminin-5, laminin-6, and type VII collagen.

    Lawrence S. Chan;Lawrence S. Chan;Jean Christophe Lapiere;Mei Chen;Tom Traczyk

  • Wiskott-Aldrich syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptor in living cells.

    Hong Yun She;Shayna Rockow;Jiping Tang;Riko Nishimura

  • Evidence that Anti-Type VII Collagen Antibodies Are Pathogenic and Responsible for the Clinical, Histological, and Immunological Features of Epidermolysis Bullosa Acquisita

    David T. Woodley;Carl Chang;Payam Saadat;Ramin Ram

  • Laminin-6 and Laminin-5 Are Recognized by Autoantibodies in a Subset of Cicatricial Pemphigoid

    Lawrence S. Chan;Arpana A. Majmudar;Hoang H. Tran;Friedegund Meier

  • Intravenously injected human fibroblasts home to skin wounds, deliver type VII collagen, and promote wound healing.

    David T Woodley;Jennifer Remington;Yi Huang;Yingping Hou

  • NC1 domain of type VII collagen binds to the β3 chain of laminin 5 via a unique subdomain within the fibronectin-like repeats

    Mei Chen;Jonathan C.R. Jones;Edel A. O'Toole;Yu-Yu Li

Frequent Co-Authors

David T. Woodley
David T. Woodley University of Southern California
Douglas R. Keene
Douglas R. Keene Shriners Hospitals for Children - Portland
Edel A. O'Toole
Edel A. O'Toole Queen Mary University of London
John A. McGrath
John A. McGrath King's College London
Jakub Tolar
Jakub Tolar University of Minnesota
Alain Hovnanian
Alain Hovnanian Imagine Institute for Genetic Diseases
Jouni Uitto
Jouni Uitto Thomas Jefferson University
John E. Wagner
John E. Wagner University of Minnesota
Janet A. Fairley
Janet A. Fairley University of Iowa
M. Peter Marinkovich
M. Peter Marinkovich Stanford University

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