World's Best Scientists 2026 revealed!
Zygmunt S. Derewenda

Zygmunt S. Derewenda

D-Index & Metrics

Biology and Biochemistry

D-Index
68
Citations
18661
World Ranking
7718
National Ranking
3518

Overview

Zygmunt S. Derewenda is a researcher affiliated with the University of Virginia in the United States. Their work focuses on biochemistry, genetics, molecular biology, and chemistry, with significant contributions in molecular biology and physical and theoretical chemistry subfields. The main research themes revolve around crystallography and molecular interactions, protein structure and dynamics, as well as protein kinase regulation and GTPase signaling.

Several recent publications highlight Derewenda's research interests. These include:

  • C-H Groups as Donors in Hydrogen Bonds: A Historical Overview and Occurrence in Proteins and Nucleic Acids (2023, International Journal of Molecular Sciences)
  • <scp>CH</scp>⋯O hydrogen bonds in kinase-inhibitor interfaces (2020, IUBMB Life)
  • On the centennials of the discoveries of the hydrogen bond and the structure of the water molecule: the short life and work of Eustace Jean Cuy (1897-1925) (2021, Acta Crystallographica Section A Foundations and Advances)

Derewenda has also been connected as a coauthor on papers addressing related topics, such as:

  • A structural role for tryptophan in proteins, and the ubiquitous Trp C δ1 -H...O=C (backbone) hydrogen bond (2024, Acta Crystallographica Section D Structural Biology)
  • Differing Effects of Nonlinearity around the Proton Acceptor on CH··O and NH··O H-Bond Strength within Proteins (2024, The Journal of Physical Chemistry B)

Frequent coauthors collaborating with Derewenda include Urszula Derewenda, Steve Scheiner, W. Minor, Michal Szczygiel, and Jaspreet Kalra. Collaboration appears to be a notable feature of their research approach, reflected in the multiple coauthored studies.

The researcher's publications appear regularly in several scientific venues, notably:

  • Acta Crystallographica Section D Structural Biology
  • Acta Crystallographica Section A Foundations and Advances
  • Structural Dynamics
  • International Journal of Molecular Sciences
  • IUBMB Life

Derewenda's work centers on topics such as crystallography and molecular interactions, protein structure and dynamics, protein kinase regulation and GTPase signaling, chemical synthesis and analysis, molecular sensors and ion detection, computational drug discovery methods, and enzyme structure and function. This broad range of research areas underscores a multidisciplinary approach within the fields of biochemistry and chemistry.

Best Publications

  • A serine protease triad forms the catalytic centre of a triacylglycerol lipase.

    Leo Brady;Andrzej M. Brzozowski;Andrzej M. Brzozowski;Zygmunt S. Derewenda;Eleanor Dodson

  • A model for interfacial activation in lipases from the structure of a fungal lipase-inhibitor complex

    A. M. Brzozowski;A. M. Brzozowski;U. Derewenda;U. Derewenda;Z. S. Derewenda;Z. S. Derewenda;G. G. Dodson

  • Overcoming Expression and Purification Problems of RhoGDI Using a Family of “Parallel” Expression Vectors☆

    Peter Sheffield;Sarah Garrard;Zygmunt Derewenda

  • Catalysis at the interface: the anatomy of a conformational change in a triglyceride lipase.

    Urszula Derewenda;Andrzej M. Brzozowski;David M. Lawson;Zygmunt S. Derewenda

  • The occurrence of C-H...O hydrogen bonds in proteins.

    Zygmunt S. Derewenda;Linda Lee;Urszula Derewenda

  • High-resolution (1.5 Å) crystal structure of phospholipase C from Bacillus cereus

    Edward Hough;Lars Kristian Hansen;Bjørn Birknes;Knut Jynge

  • Calcium binding in alpha-amylases: an X-ray diffraction study at 2.1-A resolution of two enzymes from Aspergillus.

    E. Boel;L. Brady;A. M. Brzozowski;A. M. Brzozowski;Z. Derewenda

  • Phenol stabilizes more helix in a new symmetrical zinc insulin hexamer

    U. Derewenda;Z. Derewenda;E. J. Dodson;G. G. Dodson

  • Rational protein crystallization by mutational surface engineering.

    Zygmunt S. Derewenda

  • Toward rational protein crystallization: A Web server for the design of crystallizable protein variants

    Lukasz Goldschmidt;David R. Cooper;Zygmunt S. Derewenda;David Eisenberg;David Eisenberg

  • The crystal and molecular structure of the Rhizomucor miehei triacylglyceride lipase at 1.9 A resolution.

    Zygmunt S. Derewenda;Urszula Derewenda;Guy G. Dodson

  • The structure of the saccharide-binding site of concanavalin A.

    Z. Derewenda;J. Yariv;J.R. Helliwell;A.J. Kalb

  • Entropy and surface engineering in protein crystallization.

    Zygmunt S. Derewenda;Peter G. Vekilov

  • (His)Cε-H···O=C< Hydrogen Bond in the Active Sites of Serine Hydrolases

    Z.S. Derewenda;U. Derewenda;P.M. Kobos

  • Conformational lability of lipases observed in the absence of an oil-water interface: crystallographic studies of enzymes from the fungi Humicola lanuginosa and Rhizopus delemar.

    U Derewenda;L Swenson;Y Wei;R Green

  • News from the interface: the molecular structures of triacyglyceride lipases

    Zygmunt S. Derewenda;Allan M. Sharp

  • Crystal structure of RhoA–GDP and its functional implications

    Yunyi Wei;Yan Zhang;Urszula Derewenda;Xiaopu Liu

  • The Escherichia coli malonyl-CoA:acyl carrier protein transacylase at 1.5-A resolution. Crystal structure of a fatty acid synthase component.

    Laurence Serre;Elizabeth C. Verbree;Zbigniew Dauter;Antoine R. Stuitje

  • X-ray analysis of the single chain B29-A1 peptide-linked insulin molecule. A completely inactive analogue.

    U. Derewenda;Z. Derewenda;E.J. Dodson;G.G. Dodson

  • The use of recombinant methods and molecular engineering in protein crystallization.

    Zygmunt S. Derewenda

Frequent Co-Authors

Guy Dodson
Guy Dodson University of York
Avril V. Somlyo
Avril V. Somlyo University of Virginia
Eleanor J. Dodson
Eleanor J. Dodson University of York
John H. Bushweller
John H. Bushweller University of Virginia
Andrzej Joachimiak
Andrzej Joachimiak Argonne National Laboratory
Junken Aoki
Junken Aoki Tohoku University
Hiroyuki Arai
Hiroyuki Arai University of Tokyo
John R. Helliwell
John R. Helliwell University of Manchester
P. Todd Stukenberg
P. Todd Stukenberg University of Virginia
Zbigniew Dauter
Zbigniew Dauter Brookhaven National Laboratory

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Studying Biology and Biochemistry opens up a diverse set of career options, especially with the growing demand for professionals in healthcare and life sciences. Many students consider pursuing online degrees for flexibility and affordability. If you’re interested in management roles, you might look at the cheapest online MBA healthcare management programs. These programs can help launch careers in hospital administration or healthcare consulting.

For those attracted to specialized healthcare roles, earning a certified coding specialist (ccs) credential can be a great fit. CCS certification equips you to handle complex medical coding in hospitals and clinics. Curious how quickly you can join the field? Learn about how long does it take to become a medical coder and the education pathways available.

The healthcare industry’s shift to digital records has fueled demand for coding professionals. Fortunately, the job outlook for medical billing and coding is strong, offering stability, remote work possibilities, and clear advancement paths. These rewarding careers can be a natural next step for Biology and Biochemistry graduates seeking practical applications of their scientific knowledge.

Best Scientists Citing Zygmunt S. Derewenda

Trending Scientists

Recently Published Articles