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Biology and Biochemistry

D-Index
49
Citations
6721
World Ranking
18142
National Ranking
7412

Overview

Thomas R. Shearer is affiliated with Oregon Health & Science University in the United States. Their research spans multiple fields, with a focus on Medicine and Biochemistry, Genetics, and Molecular Biology. Within these domains, their subfields of study include Ophthalmology, Cell Biology, Molecular Biology, General Dentistry, and General Health Professions.

Their scholarly output covers topics such as Retinal Diseases and Treatments, Retinal and Optic Conditions, Ocular Diseases and Behçet's Syndrome, Calpain Protease Function and Regulation, Connexins and lens biology, Endoplasmic Reticulum Stress and Disease, and Dental Research and COVID-19.

Thomas R. Shearer has coauthored several publications with recurring collaborators including Mitsuyoshi Azuma, Momoko Kobayashi-Otsugu, Kana Orihara, Emi Nakajima, and Peter Steinkamp.

Their research has been published in a variety of venues, notably:

  • PLoS ONE (2 publications)
  • Investigative Ophthalmology & Visual Science (1 publication)
  • Journal of Dental Education (1 publication)
  • PubMed (1 publication)

Notable recent papers authored or coauthored by Thomas R. Shearer include:

  • "Activation of Cytosolic Calpain, Not Caspase, Is Underlying Mechanism for Hypoxic RGC Damage in Human Retinal Explants," 2020, Investigative Ophthalmology & Visual Science
  • "Segmenting OCT for detecting drug efficacy in CRAO," 2020, PLoS ONE
  • "A descriptive analysis of predoctoral surgical requirements in US dental schools in 2020," 2021, Journal of Dental Education
  • "GCL loss in BRAO," 2023, PLoS ONE
  • "Calpain-specific breakdown fragment in human drusen," 2024, PubMed

Best Publications

  • Age-related changes in human lens crystallins identified by two- dimensional electrophoresis and mass spectrometry

    Kirsten J. Lampi;Zhixiang Ma;Stacy R.A. Hanson;Misuyoshi Azuma

  • Selenite nuclear cataract: review of the model.

    T R Shearer;H Ma;C Fukiage;M Azuma

  • Sequence Analysis of βA3, βB3, and βA4 Crystallins Completes the Identification of the Major Proteins in Young Human Lens

    Kirsten J. Lampi;Zhixiang Ma;Marjorie Shih;Thomas R. Shearer

  • Evidence that an Isoform of Calpain-10 Is a Regulator of Exocytosis in Pancreatic β-Cells

    Catriona Marshall;Graham A. Hitman;Christopher J. Partridge;Anne Clark

  • Review of selenite cataract.

    Thomas R. Shearer;Larry L. David;Ruth S. Anderson;Mitsuyoshi Azuma

  • Characterization and Expression of Calpain 10: A NOVEL UBIQUITOUS CALPAIN WITH NUCLEAR LOCALIZATION

    Hong Ma;Chiho Fukiage;Yung Hae Kim;Yung Hae Kim;Melinda K. Duncan

  • Contribution of ROCK in Contraction of Trabecular Meshwork: Proposed Mechanism for Regulating Aqueous Outflow in Monkey and Human Eyes

    Emi Nakajima;Takeshi Nakajima;Yoko Minagawa;Thomas R. Shearer

  • Sequence analysis of lens beta-crystallins suggests involvement of calpain in cataract formation.

    L L David;T R Shearer;M Shih

  • Calcium-activated proteolysis in the lens nucleus during selenite cataractogenesis.

    L L David;T R Shearer

  • Lens proteomics: analysis of rat crystallin sequences and two-dimensional electrophoresis map.

    Kirsten J. Lampi;Marjorie Shih;Yoji Ueda;Thomas R. Shearer

  • Purification of calpain II from rat lens and determination of endogenous substrates.

    Larry L. David;Thomas R. Shearer;Thomas R. Shearer

  • alpha-Crystallin chaperone activity is reduced by calpain II in vitro and in selenite cataract.

    M.J. Kelley;L.L. David;N. Iwasaki;J. Wright

  • Cloning and expression of mRNA for calpain Lp82 from rat lens: splice variant of p94.

    Hong Ma;Chiho Fukiage;Mitsuyoshi Azuma;Thomas R. Shearer

  • SJA6017, A NEWLY SYNTHESIZED PEPTIDE ALDEHYDE INHIBITOR OF CALPAIN : AMELIORATION OF CATARACT IN CULTURED RAT LENSES

    Chiho Fukiage;Mitsuyoshi Azuma;Yoshikuni Nakamura;Yoshiyuki Tamada

  • Selenite cataract: a review.

    T. R. Shearer;L. L. David;R. S. Anderson

  • Cataract and the acceleration of calpain-induced beta-crystallin insolubilization occurring during normal maturation of rat lens.

    L L David;M Azuma;T R Shearer

  • The Role of Calcium Activated Protease Calpain in Experimental Retinal Pathology

    M. Azuma;T.R. Shearer

  • Calpain II in human lens.

    Larry L. David;Michael D. Varnum;Kirsten J. Lampi;Thomas R. Shearer

  • Geographic Distribution of Selenium in Human Milk

    Thomas R. Shearer;Demetrios M. Hadjimarkos

  • Involvement of calpain isoforms in ischemia-reperfusion injury in rat retina

    Yuji Sakamoto;Takeshi Nakajima;Chiho Fukiage;Osamu Sakai

Frequent Co-Authors

Larry L. David
Larry L. David Oregon Health & Science University
Hong Ma
Hong Ma Pennsylvania State University
Hans Peter Bächinger
Hans Peter Bächinger Oregon Health & Science University
David L. Smith
David L. Smith University of Nebraska–Lincoln
Jacques S. Beckmann
Jacques S. Beckmann University of Lausanne
John A. Carver
John A. Carver Australian National University
Takashi Murachi
Takashi Murachi Kyoto University
Graham A. Hitman
Graham A. Hitman Queen Mary University of London

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