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Biology and Biochemistry

D-Index
70
Citations
18885
World Ranking
6960
National Ranking
129

Overview

Andrea Carfi is affiliated with Novartis in Switzerland, focusing on research in medicine and immunology. Their work primarily addresses infectious diseases, epidemiology, and molecular biology, with a notable emphasis on the study of viral infections and immune responses.

Their research concentrates on several main topics, including:

  • SARS-CoV-2 and COVID-19 research
  • Animal virus infections studies
  • Viral gastroenteritis research and epidemiology
  • Immunotherapy and immune responses
  • Herpesvirus infections and treatments
  • HIV research and treatment
  • Viral infections and immunology research

Andrea Carfi has published numerous papers in leading scientific venues, with frequent appearances in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Science Translational Medicine
  • Cell
  • Nature Communications
  • Science

Some recent publications include:

  • SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness, 2020, Nature
  • Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates, 2020, New England Journal of Medicine
  • Durability of mRNA-1273 vaccine-induced antibodies against SARS-CoV-2 variants, 2021, Science
  • mRNA-1273 vaccine induces neutralizing antibodies against spike mutants from global SARS-CoV-2 variants, 2021, bioRxiv (Cold Spring Harbor Laboratory)
  • Serum Neutralizing Activity Elicited by mRNA-1273 Vaccine, 2021, New England Journal of Medicine

They have collaborated extensively with other researchers in the field, frequently coauthoring with:

  • Darin K. Edwards
  • Kaichun Wu (28 works)
  • Barney S. Graham (27 works)
  • Kizzmekia S. Corbett (24 works)
  • Sayda M. Elbashir (22 works)

Their research contributions bridge multiple subfields of study, primarily:

  • Infectious diseases
  • Epidemiology
  • Immunology
  • Animal science and zoology
  • Molecular biology

Andrea Carfi's extensive work on SARS-CoV-2 and vaccine-related science situates their expertise within pandemic preparedness and immunological responses, contributing to understanding and combatting viral threats through biomedical innovation.

Best Publications

  • SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness.

    Kizzmekia S. Corbett;Darin K. Edwards;Sarah R. Leist;Olubukola M. Abiona

  • Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates.

    Kizzmekia S Corbett;Barbara Flynn;Kathryn E Foulds;Joseph R Francica

  • Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases.

    A. Lahm;C. Paolini;M. Pallaoro;M. C. Nardi

  • The 3-D structure of a zinc metallo-beta-lactamase from Bacillus cereus reveals a new type of protein fold.

    A. Carfi;S. Pares;E. Duée;Moreno Galleni

  • Crystal structure of the Ebola virus membrane fusion subunit, GP2, from the envelope glycoprotein ectodomain.

    Winfried Weissenhorn;Andrea Carfí;Kon-Ho Lee;John J. Skehel

  • mRNA-1273 vaccine induces neutralizing antibodies against spike mutants from global SARS-CoV-2 variants

    Kai Wu;Anne P. Werner;Juan I. Moliva;Matthew Koch

  • Molecular Insights into Quorum Sensing in the Human Pathogen Pseudomonas aeruginosa from the Structure of the Virulence Regulator LasR Bound to Its Autoinducer

    Matthew James Bottomley;Ester Muraglia;Renzo Bazzo;Andrea Carfì

  • Herpes simplex virus glycoprotein D bound to the human receptor HveA.

    Andrea Carfı́;Sharon H. Willis;J.Charles Whitbeck;Claude Krummenacher

  • Serum Neutralizing Activity Elicited by mRNA-1273 Vaccine.

    Kai Wu;Anne P Werner;Matthew Koch;Angela Choi

  • Structural and Functional Analysis of the Human HDAC4 Catalytic Domain Reveals a Regulatory Structural Zinc-binding Domain

    Matthew J. Bottomley;Paola Lo Surdo;Paolo Di Giovine;Agostino Cirillo

  • Safety and immunogenicity of SARS-CoV-2 variant mRNA vaccine boosters in healthy adults: an interim analysis.

    Angela Choi;Matthew Koch;Kai Wu;Laurence Chu

  • Structure of Unliganded Hsv Gd Reveals a Mechanism for Receptor-Mediated Activation of Virus Entry.

    Claude Krummenacher;Vinit M Supekar;J Charles Whitbeck;Eric Lazear

  • Structural basis for immunization with postfusion respiratory syncytial virus fusion F glycoprotein (RSV F) to elicit high neutralizing antibody titers

    Kurt A. Swanson;Ethan C. Settembre;Christine A. Shaw;Antu K. Dey

  • Structure of a covalently stabilized complex of a human alphabeta T-cell receptor, influenza HA peptide and MHC class II molecule, HLA-DR1.

    Jens Hennecke;Andrea Carfi;Don C. Wiley

  • Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8-substrate complex.

    Alessandro Vannini;Cinzia Volpari;Paola Gallinari;Philip Jones

  • Immune correlates of protection by mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates.

    Kizzmekia S. Corbett;Martha C. Nason;Britta Flach;Matthew Gagne

  • Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody

    A.G Schmidt;H Xu;A.R Khan;T O'Donnell

  • Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH

    Paola Lo Surdo;Matthew J Bottomley;Alessandra Calzetta;Ethan C Settembre

  • Effects of pH and Low Density Lipoprotein (LDL) on PCSK9-dependent LDL Receptor Regulation

    Timothy S. Fisher;Paola Lo Surdo;Shilpa Pandit;Marco Mattu

  • Novel approaches for vaccine development.

    Makda S. Gebre;Luis A. Brito;Lisa H. Tostanoski;Darin K. Edwards

Frequent Co-Authors

Gary H. Cohen
Gary H. Cohen University of Pennsylvania
Roselyn J. Eisenberg
Roselyn J. Eisenberg University of Pennsylvania
Raffaele De Francesco
Raffaele De Francesco University of Milan
Don C. Wiley
Don C. Wiley Harvard University
Wah Chiu
Wah Chiu Stanford University
Susan W. Barnett
Susan W. Barnett Bill & Melinda Gates Foundation
Kizzmekia S. Corbett
Kizzmekia S. Corbett Harvard University
Philip R. Dormitzer
Philip R. Dormitzer Pfizer (United States)
Otto Dideberg
Otto Dideberg Centre national de la recherche scientifique, CNRS

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