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Raffaele De Francesco

Raffaele De Francesco

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Biology and Biochemistry
Italy
2023

D-Index & Metrics

Microbiology

D-Index
76
Citations
17591
World Ranking
1446
National Ranking
38

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Italy Leader Award

Overview

Raffaele De Francesco is affiliated with the University of Milan in Italy and has an extensive publication record in the field of medicine, focusing primarily on infectious diseases. Their research portfolio includes a strong emphasis on SARS-CoV-2 and COVID-19, covering clinical research, immunoinformatics approaches in vaccine development, and immune response mechanisms.

The main fields of study represented in their work are Medicine, with significant research contributions in Infectious Diseases, Molecular Biology, Immunology, Neurology, and Epidemiology. Their involvement in these subfields is reflected in the diversity of topics addressed in their papers.

Among the topics addressed in De Francesco's research are:

  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 Clinical Research Studies
  • Vaccines and Immunoinformatics Approaches
  • Hepatitis C Virus Research
  • Long-Term Effects of COVID-19
  • Interferon and Immune Responses
  • Viral Gastroenteritis Research and Epidemiology

Notable recent papers authored or co-authored by Raffaele De Francesco include:

  • Integrated longitudinal immunophenotypic, transcriptional, and repertoire analyses delineate immune responses in patients with COVID-19 (2021, Science Immunology)
  • Administration of aerosolized SARS-CoV-2 to K18-hACE2 mice uncouples respiratory infection from fatal neuroinvasion (2022, Science Immunology)
  • Exosomes Recovered From the Plasma of COVID-19 Patients Expose SARS-CoV-2 Spike-Derived Fragments and Contribute to the Adaptive Immune Response (2022, Frontiers in Immunology)
  • COVID-eVax, an electroporated DNA vaccine candidate encoding the SARS-CoV-2 RBD, elicits protective responses in animal models (2021, Molecular Therapy)
  • Memory CD8+ T cell diversity and B cell responses correlate with protection against SARS-CoV-2 following mRNA vaccination (2022, Nature Immunology)

Frequent co-authors contributing to De Francesco's research include:

  • Lorena Donnici
  • Lara Manganaro
  • Matteo Conti
  • Matteo Iannacone
  • Luca G. Guidotti

De Francesco has commonly published in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Science Immunology
  • Frontiers in Immunology
  • Nature Immunology
  • Pharmacological Research

Best Publications

  • Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor

    Alessandro Vannini;Cinzia Volpari;Gessica Filocamo;Elena Caroli Casavola

  • Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells

    Marco De Simone;Alberto Arrigoni;Grazisa Rossetti;Paola Gruarin

  • Challenges and successes in developing new therapies for hepatitis C

    Raffaele De Francesco;Giovanni Migliaccio

  • Structural Analysis of the Hepatitis C Virus RNA Polymerase in Complex with Ribonucleotides

    Stéphane Bressanelli;Licia Tomei;Félix A. Rey;Raffaele De Francesco

  • The crystal structure of the quorum sensing protein TraR bound to its autoinducer and target DNA

    Alessandro Vannini;Cinzia Volpari;Cesare Gargioli;Ester Muraglia

  • Inhibition of Hepatitis C Virus RNA Replication by 2′-Modified Nucleoside Analogs

    Steven S. Carroll;Joanne E. Tomassini;Michele Bosserman;Krista Getty

  • Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses.

    Giulia Nizzoli;Jana Krietsch;Anja Weick;Svenja Steinfelder

  • Structural and Functional Analysis of the Human HDAC4 Catalytic Domain Reveals a Regulatory Structural Zinc-binding Domain

    Matthew J. Bottomley;Paola Lo Surdo;Paolo Di Giovine;Agostino Cirillo

  • Characterization of Resistance to Non-obligate Chain-terminating Ribonucleoside Analogs That Inhibit Hepatitis C Virus Replication in Vitro

    Giovanni Migliaccio;Joanne E. Tomassini;Steven S. Carroll;Licia Tomei

  • The long intergenic noncoding RNA landscape of human lymphocytes highlights the regulation of T cell differentiation by linc-MAF-4

    Valeria Ranzani;Grazisa Rossetti;Ilaria Panzeri;Alberto Arrigoni

  • Approaching a new era for hepatitis C virus therapy: inhibitors of the NS3-4A serine protease and the NS5B RNA-dependent RNA polymerase

    Raffaele De Francesco;Licia Tomei;Sergio Altamura;Vincenzo Summa

  • Distinct microRNA signatures in human lymphocyte subsets and enforcement of the naive state in CD4 + T cells by the microRNA miR-125b

    Riccardo L Rossi;Grazisa Rossetti;Lynn Wenandy;Serena Curti

  • Product inhibition of the hepatitis C virus NS3 protease.

    Christian Steinkühler;Gabriella Biasiol;Mirko Brunetti;Andrea Urbani

  • Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8-substrate complex.

    Alessandro Vannini;Cinzia Volpari;Paola Gallinari;Philip Jones

  • Potent peptide inhibitors of human hepatitis C virus NS3 protease are obtained by optimizing the cleavage products.

    P Ingallinella;S Altamura;E Bianchi;M Taliani

  • Multiple Enzymatic Activities Associated with Recombinant NS3 Protein of Hepatitis C Virus

    Paola Gallinari;Debra Brennan;Chiara Nardi;Mirko Brunetti

  • Effects of pH and Low Density Lipoprotein (LDL) on PCSK9-dependent LDL Receptor Regulation

    Timothy S. Fisher;Paola Lo Surdo;Shilpa Pandit;Marco Mattu

  • Mechanism of Action and Antiviral Activity of Benzimidazole-Based Allosteric Inhibitors of the Hepatitis C Virus RNA-Dependent RNA Polymerase

    Licia Tomei;Sergio Altamura;Linda Bartholomew;Antonino Biroccio

  • Interdomain Communication in Hepatitis C Virus Polymerase Abolished by Small-Molecule Inhibitors Bound to a Novel Allosteric Site

    Stefania Di Marco;Cinzia Volpari;Licia Tomei;Sergio Altamura

  • Phosphorylation of hepatitis C virus NS5A nonstructural protein: a new paradigm for phosphorylation-dependent viral RNA replication?

    Ying Huang;Kirk Staschke;Raffaele De Francesco;Seng-Lai Tan

Frequent Co-Authors

Sergio Abrignani
Sergio Abrignani University of Milan
Elisabetta Bianchi
Elisabetta Bianchi Institut Pasteur
Riccardo Cortese
Riccardo Cortese Schering-Plough
Michael Rowley
Michael Rowley Pharmaron (United Kingdom)
Massimo Colombo
Massimo Colombo Humanitas University
Andrea Carfi
Andrea Carfi Novartis (Switzerland)
Anna Tramontano
Anna Tramontano Sapienza University of Rome
Andrea Urbani
Andrea Urbani University of Padua
Luca Valenti
Luca Valenti University of Milan

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