What is he best known for?
The fields of study he is best known for:
Christian Steinkühler focuses on NS3, Biochemistry, Protease, Histone and Serine protease.
His studies in NS3 integrate themes in fields like NS2-3 protease, Stereochemistry and Peptide.
His Biochemistry research focuses on HDAC8 in particular.
Christian Steinkühler works mostly in the field of Protease, limiting it down to concerns involving Molecular biology and, occasionally, Malignant transformation, Muscular dystrophy and Cancer research.
The concepts of his Histone study are interwoven with issues in Protein structure, Chromatin, Acetylation and Repressor.
Christian Steinkühler interconnects Product inhibition and Virology in the investigation of issues within Serine protease.
His most cited work include:
- Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor (502 citations)
- Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases. (407 citations)
- HDACs, histone deacetylation and gene transcription: from molecular biology to cancer therapeutics. (352 citations)
What are the main themes of his work throughout his whole career to date?
Biochemistry, NS3, Protease, Enzyme and NS2-3 protease are his primary areas of study.
His work on Molecular biology expands to the thematically related Biochemistry.
Christian Steinkühler combines subjects such as Serine protease, Stereochemistry, Binding site and Peptide with his study of NS3.
Christian Steinkühler works mostly in the field of Protease, limiting it down to topics relating to Cleavage and, in certain cases, Enzyme kinetics, as a part of the same area of interest.
His Histone deacetylase research integrates issues from Hydroxamic acid and Cancer research.
His studies deal with areas such as Substrate, Acetylation and Repressor as well as Histone.
He most often published in these fields:
- Biochemistry (50.75%)
- NS3 (32.84%)
- Protease (25.37%)
What were the highlights of his more recent work (between 2010-2021)?
- Biochemistry (50.75%)
- In vivo (7.46%)
- Cancer research (11.19%)
In recent papers he was focusing on the following fields of study:
His primary areas of investigation include Biochemistry, In vivo, Cancer research, In vitro and Cancer stem cell.
His study in the field of Prodrug and Enzyme also crosses realms of Linker.
His Enzyme research incorporates themes from Inflammation, Proinflammatory cytokine, Macrophage and Viral egress.
Christian Steinkühler has included themes like Cell and Immunology in his Cancer research study.
His Immunology research focuses on Medulloblastoma and how it connects with Cellular differentiation, Histone deacetylase complex and Molecular biology.
In his study, which falls under the umbrella issue of Cancer stem cell, Pharmacology, Cancer relapse, Cancer chemotherapy and Leukemia is strongly linked to Sirtuin.
Between 2010 and 2021, his most popular works were:
- Discovery of Salermide-Related Sirtuin Inhibitors: Binding Mode Studies and Antiproliferative Effects in Cancer Cells Including Cancer Stem Cells (64 citations)
- Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclo- propyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydro-imidazo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, part 2. (53 citations)
- Benzodeazaoxaflavins as Sirtuin Inhibitors with Antiproliferative Properties in Cancer Stem Cells (28 citations)
In his most recent research, the most cited papers focused on:
His main research concerns Smoothened, Hedgehog signaling pathway, Hedgehog, Pharmacology and Cancer stem cell.
Smoothened and Stereochemistry are frequently intertwined in his study.
His research integrates issues of Signal transduction and Piperazine in his study of Stereochemistry.
His Pharmacology research incorporates elements of Colorectal cancer, Glioblastoma and Sirtuin.
Christian Steinkühler focuses mostly in the field of Colorectal cancer, narrowing it down to topics relating to Cancer relapse and, in certain cases, Cancer research.
His biological study spans a wide range of topics, including Molecular biology, Histone deacetylase complex and Medulloblastoma.
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