Christian Steinkühler

Overview

Best Publications

• Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor

  Alessandro Vannini;Cinzia Volpari;Gessica Filocamo;Elena Caroli Casavola

  781
  Citations

• HDACs, histone deacetylation and gene transcription: from molecular biology to cancer therapeutics.

  Paola Gallinari;Stefania Di Marco;Phillip Jones;Michele Pallaoro

  653
  Citations

• Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases.

  A. Lahm;C. Paolini;M. Pallaoro;M. C. Nardi

  608
  Citations

• Structural and Functional Analysis of the Human HDAC4 Catalytic Domain Reveals a Regulatory Structural Zinc-binding Domain

  Matthew J. Bottomley;Paola Lo Surdo;Paolo Di Giovine;Agostino Cirillo

  380
  Citations

• Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation

  Gianluca Canettieri;Lucia Di Marcotullio;Azzura Greco;Sonia Coni

  376
  Citations

• Functional and morphological recovery of dystrophic muscles in mice treated with deacetylase inhibitors.

  G C Minetti;C Colussi;R Adami;C Serra

  361
  Citations

• Product inhibition of the hepatitis C virus NS3 protease.

  Christian Steinkühler;Gabriella Biasiol;Mirko Brunetti;Andrea Urbani

  314
  Citations

• Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8-substrate complex.

  Alessandro Vannini;Cinzia Volpari;Paola Gallinari;Philip Jones

  305
  Citations

• HDAC2 blockade by nitric oxide and histone deacetylase inhibitors reveals a common target in Duchenne muscular dystrophy treatment

  Claudia Colussi;Chiara Mozzetta;Aymone Gurtner;Barbara Illi

  276
  Citations

• Potent peptide inhibitors of human hepatitis C virus NS3 protease are obtained by optimizing the cleavage products.

  P Ingallinella;S Altamura;E Bianchi;M Taliani

  250
  Citations

• Multiple Enzymatic Activities Associated with Recombinant NS3 Protein of Hepatitis C Virus

  Paola Gallinari;Debra Brennan;Chiara Nardi;Mirko Brunetti

  249
  Citations

• A designed P1 cysteine mimetic for covalent and non-covalent inhibitors of HCV NS3 protease.

  Frank Narjes;Konrad F Koehler;Uwe Koch;Benjamin Gerlach

  191
  Citations

• Activity of purified hepatitis C virus protease NS3 on peptide substrates.

  C Steinkühler;A Urbani;L Tomei;G Biasiol

  188
  Citations

• A continuous assay of hepatitis C virus protease based on resonance energy transfer depsipeptide substrates.

  Marina Taliani;Elisabetta Bianchi;Frank Narjes;Marco Fossatelli

  172
  Citations

• Inhibition of class I histone deacetylase with an apicidin derivative prevents cardiac hypertrophy and failure

  Pasquale Gallo;Michael V G Latronico;Paolo Gallo;Paolo Gallo;Serena Grimaldi

  170
  Citations

• The solution structure of the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein provides new insights into its activation and catalytic mechanism.

  G Barbato;D.O Cicero;M.C Nardi;C Steinkuhler

  167
  Citations

• In vitro selection and characterization of hepatitis C virus serine protease variants resistant to an active-site peptide inhibitor

  Caterina Trozzi;Linda Bartholomew;Alessandra Ceccacci;Gabriella Biasiol

  157
  Citations

• PP2A regulates HDAC4 nuclear import.

  Gabriela Paroni;Gabriela Paroni;Nadia Cernotta;Claudio Dello Russo;Paola Gallinari

  148
  Citations

• Affinity selection of a camelized V(H) domain antibody inhibitor of hepatitis C virus NS3 protease.

  F Martin;C Volpari;C Steinkuhler;N Dimasi

  142
  Citations

• Structure and function of the hepatitis C virus NS3-NS4A serine proteinase

  R. De Francesco;C. Steinkühler

  138
  Citations