D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 67 Citations 14,950 213 World Ranking 3621 National Ranking 53

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Gene
  • Biochemistry

Giuseppe Rotilio spends much of his time researching Biochemistry, Superoxide dismutase, Cell biology, Glutathione and Copper. His Biochemistry research incorporates themes from Cancer cell and Molecular biology. The concepts of his Superoxide dismutase study are interwoven with issues in Inorganic chemistry, Electron paramagnetic resonance and Superoxide.

His Cell biology study incorporates themes from Amyotrophic lateral sclerosis and Neurodegeneration. His research investigates the connection with Glutathione and areas like Intracellular which intersect with concerns in Virus, Thioredoxin, Buthionine sulfoximine, Extracellular and Programmed cell death. Giuseppe Rotilio has included themes like Zinc, Metallothionein, Metal and Nuclear chemistry in his Copper study.

His most cited work include:

  • Aspects of the structure, function, and applications of superoxide dismutase (756 citations)
  • Reduction and inactivation of superoxide dismutase by hydrogen peroxide (349 citations)
  • Rescue of cells from apoptosis by inhibition of active GSH extrusion (302 citations)

What are the main themes of his work throughout his whole career to date?

The scientist’s investigation covers issues in Superoxide dismutase, Biochemistry, Copper, Enzyme and Inorganic chemistry. His Superoxide dismutase research incorporates elements of Crystallography, Zinc, Superoxide and Active site. As part of his studies on Biochemistry, Giuseppe Rotilio often connects relevant subjects like Molecular biology.

Giuseppe Rotilio focuses mostly in the field of Copper, narrowing it down to matters related to Electron paramagnetic resonance and, in some cases, Cobalt and Titration. In his study, Cell culture is inextricably linked to Intracellular, which falls within the broad field of Glutathione. He studied Reactive oxygen species and Oxidative stress that intersect with Neurodegeneration.

He most often published in these fields:

  • Superoxide dismutase (43.35%)
  • Biochemistry (38.29%)
  • Copper (31.65%)

What were the highlights of his more recent work (between 2004-2018)?

  • Biochemistry (38.29%)
  • Cell biology (14.24%)
  • Oxidative stress (11.39%)

In recent papers he was focusing on the following fields of study:

Giuseppe Rotilio mainly focuses on Biochemistry, Cell biology, Oxidative stress, Apoptosis and Reactive oxygen species. The Biochemistry study combines topics in areas such as Redox and Copper. His Cell biology research focuses on SH-SY5Y and how it connects with Viability assay, Copper toxicity, Toxicity and Pyruvate dehydrogenase complex.

His Oxidative stress research is multidisciplinary, incorporating elements of Tetrahydrobiopterin, Neurodegeneration, Disease and Antioxidant. His Apoptosis research is multidisciplinary, relying on both Schiff base, Molecular biology and AMPK. His Superoxide dismutase study results in a more complete grasp of Enzyme.

Between 2004 and 2018, his most popular works were:

  • Peroxisome Proliferator-activated Receptor γ Co-activator 1α (PGC-1α) and Sirtuin 1 (SIRT1) Reside in Mitochondria: POSSIBLE DIRECT FUNCTION IN MITOCHONDRIAL BIOGENESIS* (250 citations)
  • Familial ALS-superoxide dismutases associate with mitochondria and shift their redox potentials (203 citations)
  • High-affinity Zn2+ uptake system ZnuABC is required for bacterial zinc homeostasis in intracellular environments and contributes to the virulence of Salmonella enterica. (179 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Gene
  • Amino acid

His scientific interests lie mostly in Biochemistry, Cell biology, Oxidative stress, Apoptosis and Mitochondrion. His research in Biochemistry is mostly focused on Glutathione. His Cell biology study combines topics in areas such as Autophagy, Transcription factor and Cysteine.

His research integrates issues of Inflammation, Nitric oxide and Antioxidant in his study of Oxidative stress. His Apoptosis research includes themes of Cancer cell, Schiff base, Stereochemistry, Reactive oxygen species and Biological activity. His research investigates the connection between Mitochondrion and topics such as Neurodegeneration that intersect with issues in Amyotrophic lateral sclerosis, Mutation, SOD1, Organelle and Superoxide dismutase.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Aspects of the structure, function, and applications of superoxide dismutase

Joe V. Bannister;William H. Bannister;Giuseppe Rotilio.
CRC Critical Reviews in Biochemistry (1987)

1201 Citations

Reduction and inactivation of superoxide dismutase by hydrogen peroxide

Robert C. Bray;Stephen A. Cockle;E. Martin Fielden;Peter B. Roberts.
Biochemical Journal (1974)

535 Citations

Cell signalling and the glutathione redox system.

Giuseppe Filomeni;Giuseppe Rotilio;Maria Rosa Ciriolo.
Biochemical Pharmacology (2002)

455 Citations

The mechanism of action of superoxide dismutase from pulse radiolysis and electron paramagnetic resonance. Evidence that only half the active sites function in catalysis

E. Martin Fielden;Peter B. Roberts;Robert C. Bray;David J. Lowe.
Biochemical Journal (1974)

419 Citations

Rescue of cells from apoptosis by inhibition of active GSH extrusion

L. Ghibelli;C. Fanelli;G. Rotilio;E. Lafavia.
The FASEB Journal (1998)

379 Citations

Peroxisome Proliferator-activated Receptor γ Co-activator 1α (PGC-1α) and Sirtuin 1 (SIRT1) Reside in Mitochondria: POSSIBLE DIRECT FUNCTION IN MITOCHONDRIAL BIOGENESIS*

Katia Aquilano;Paola Vigilanza;Sara Baldelli;Beatrice Pagliei.
Journal of Biological Chemistry (2010)

329 Citations

Expression of a Cu,Zn superoxide dismutase typical of familial amyotrophic lateral sclerosis induces mitochondrial alteration and increase of cytosolic Ca2+ concentration in transfected neuroblastoma SH-SY5Y cells

Maria Teresa Carrì;Alberto Ferri;Andrea Battistoni;Laila Famhy.
FEBS Letters (1997)

307 Citations

Reactive Oxygen Species-dependent c-Jun NH2-terminal Kinase/c-Jun Signaling Cascade Mediates Neuroblastoma Cell Death Induced by Diallyl Disulfide

Giuseppe Filomeni;Katia Aquilano;Giuseppe Rotilio;Maria R. Ciriolo.
Cancer Research (2003)

267 Citations

Role of Nitric Oxide Synthases in Parkinson’s Disease: A Review on the Antioxidant and Anti-inflammatory Activity of Polyphenols

Katia Aquilano;Sara Baldelli;Giuseppe Rotilio;Maria Rosa Ciriolo.
Neurochemical Research (2008)

261 Citations

Familial ALS-superoxide dismutases associate with mitochondria and shift their redox potentials

Alberto Ferri;Mauro Cozzolino;Claudia Crosio;Monica Nencini.
Proceedings of the National Academy of Sciences of the United States of America (2006)

261 Citations

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