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D-Index & Metrics

Biology and Biochemistry

D-Index
45
Citations
12903
World Ranking
19049
National Ranking
7776

Overview

Sher Bahadur Karki is affiliated with the University of Pennsylvania in the United States. Their research primarily spans the fields of Immunology and Microbiology as well as Medicine, with a particular focus on Immunology, Radiology, Nuclear Medicine and Imaging, and Oncology as subfields.

The scientist's work centers around several main topics including:

  • Monoclonal and Polyclonal Antibodies Research
  • Immune Cell Function and Interaction
  • Immunotherapy and Immune Responses
  • CAR-T cell therapy research

Among recent publications, the following papers are notable:

  • "1372 XmAb143, an engineered IL18 heterodimeric Fc-fusion, features improved stability, reduced potency, and insensitivity to IL18BP" (2022), published in Regular and Young Investigator Award Abstracts
  • "Abstract 3515: Engineered IL18 heterodimeric Fc-fusions featuring improved stability, reduced potency, and insensitivity to IL18BP" (2022), published in Cancer Research
  • "1060 Optimally engineered IL18 Fc-fusion proteins balance potency and pharmacokinetics to promote strong anti-tumor activity" (2023), published in Regular and Young Investigator Award Abstracts

Sher Bahadur Karki frequently collaborates with several coauthors, including:

  • Alex Nisthal
  • Sung-Hyung Lee
  • Christine Bonzon
  • Ruschelle Love
  • Kendra N. Avery

The scientist's research has appeared predominantly in the venues:

  • Regular and Young Investigator Award Abstracts
  • Cancer Research

Best Publications

  • OPTIMIZED Fc VARIANTS AND METHODS FOR THEIR GENERATION

    Gregory Alan Lazar;Arthur J. Chirino;Wei Dang;John Rudolph Desjarlais

  • Engineered antibody Fc variants with enhanced effector function

    Greg A. Lazar;Wei Dang;Sher Karki;Omid Vafa

  • Enhanced antibody half-life improves in vivo activity

    Jonathan Zalevsky;Aaron K Chamberlain;Holly M Horton;Sher Karki

  • Cytoplasmic dynein and dynactin in cell division and intracellular transport.

    Sher Karki;Erika Lf Holzbaur

  • Enfortumab Vedotin Antibody–Drug Conjugate Targeting Nectin-4 Is a Highly Potent Therapeutic Agent in Multiple Preclinical Cancer Models

    Pia M. Challita-Eid;Daulet Satpayev;Peng Yang;Zili An

  • Optimized Fc Variants

    Gregory Alan Lazar;Wei Dang;John R. Desjarlais;Sher Bahadur Karki

  • Optimization of antibody binding to FcγRIIa enhances macrophage phagocytosis of tumor cells

    John O. Richards;Sher Karki;Greg A. Lazar;Hsing Chen

  • Affinity Chromatography Demonstrates a Direct Binding between Cytoplasmic Dynein and the Dynactin Complex

    Sher Karki;Erika L.F. Holzbaur

  • Engineered Fc variant antibodies with enhanced ability to recruit complement and mediate effector functions.

    Gregory L Moore;Hsing Chen;Sher Karki;Greg A Lazar

  • Potent In vitro and In vivo Activity of an Fc-Engineered Anti-CD19 Monoclonal Antibody against Lymphoma and Leukemia

    Holly M. Horton;Matthew J. Bernett;Erik Pong;Matthias Peipp

  • Immunoglobulin Variants Outside the Fc Region

    Gregory Alan Lazar;Sher Bahadur Karki

  • FC variants with altered binding to FCRN

    Aaron Keith Chamberlain;John R. Desjarlais;Sher Bahadur Karki;Greogory Alan Lazar

  • The p150Glued component of the dynactin complex binds to both microtubules and the actin-related protein centractin (Arp-1).

    Clare M. Waterman-Storer;Sher Karki;Erika L. F. Holzbaur

  • Dynein binds to β-catenin and may tether microtubules at adherens junctions

    Lee A. Ligon;Sher Karki;Mariko Tokito;Erika L. F. Holzbaur

  • Fc VARIANTS WITH OPTIMIZED PROPERTIES

    Gregory Alan Lazar;Wei Dang;John R. Desjarlais;Sher Bahadur Karki

  • The interaction between cytoplasmic dynein and dynactin is required for fast axonal transport

    Clare M. Waterman-Storer;Sher B. Karki;Sergei A. Kuznetsov;Joel S. Tabb

  • Centractin (ARP1) associates with spectrin revealing a potential mechanism to link dynactin to intracellular organelles.

    E. A. Holleran;M. K. Tokito;S. Karki;E. L. F. Holzbaur

  • IgG Immunoglobulin Variants with Optimized Effector Function

    Gregory Alan Lazar;Bassil I. Dahiyat;Wei Dang;Sher Bahadur Karki

  • Fc Variants With Optimized Fc Receptor Binding Properties

    John R. Desjarlais;Sher Bahadur Karki;Gregory Alan Lazar;John Owen Richards

  • A novel bispecific antibody format enables simultaneous bivalent and monovalent co-engagement of distinct target antigens.

    Gregory L Moore;Cristina Bautista;Erik Pong;Duc-Hanh T Nguyen

Frequent Co-Authors

John R. Desjarlais
John R. Desjarlais Pennsylvania State University
Erika L.F. Holzbaur
Erika L.F. Holzbaur University of Pennsylvania
Matthias Peipp
Matthias Peipp Kiel University
Nikhil C. Munshi
Nikhil C. Munshi Harvard University
Clare M. Waterman-Storer
Clare M. Waterman-Storer National Institutes of Health
Jeff Gelles
Jeff Gelles Brandeis University
Yu-Tzu Tai
Yu-Tzu Tai Harvard University
Richard B. Vallee
Richard B. Vallee Columbia University
Bryce M. Paschal
Bryce M. Paschal University of Virginia
John E. Cronan
John E. Cronan University of Illinois at Urbana-Champaign

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