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George Chaconas

George Chaconas

D-Index & Metrics

Molecular Biology

D-Index
48
Citations
5939
World Ranking
2702
National Ranking
85

Overview

George Chaconas is affiliated with the University of Calgary in Canada. Their research primarily focuses on the fields of Immunology and Microbiology, Biochemistry, Genetics and Molecular Biology, and Medicine. Within these domains, their work spans subfields including Parasitology, Molecular Biology, Infectious Diseases, Immunology, and Ecology, Evolution, Behavior and Systematics.

The scientist's research topics cover a range of areas such as Vector-borne infectious diseases, Viral Infections and Vectors, Toxin Mechanisms and Immunotoxins, Vector-Borne Animal Diseases, Heat shock proteins research, Leptospirosis research and findings, and Bioinformatics and Genomic Networks.

Frequent publication venues for their research include:

  • PLoS Pathogens
  • Microbiology Spectrum
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Immunology
  • Molecular Microbiology

Notable recent papers by George Chaconas include:

  • "Strain-specific joint invasion and colonization by Lyme disease spirochetes is promoted by outer surface protein C" (2020), published in PLoS Pathogens
  • "DNA lipid nanoparticle vaccine targeting outer surface protein C affords protection against homologous Borrelia burgdorferi needle challenge in mice" (2023), published in Frontiers in Immunology
  • "The Lyme disease spirochete can hijack the host immune system for extravasation from the microvasculature" (2021), published in Molecular Microbiology
  • "Choreography of Lyme Disease Spirochete Adhesins To Promote Vascular Escape" (2023), published in Microbiology Spectrum
  • "Live Imaging" (2020), published in Current Issues in Molecular Biology

The scientist collaborates frequently with Mildred Castellanos, Xi Tan, Theodore B. Verhey, Yi-Pin Lin, and Jenifer Coburn, among others.

Best Publications

  • An intravascular immune response to Borrelia burgdorferi involves Kupffer cells and iNKT cells

    Woo-Yong Lee;Tara Moriarty;Connie Hoi Yee Wong;Hong Zhou

  • Spacing and orientation of bipartite DNA-binding motifs as potential functional determinants for POU domain factors

    Peng Li;Xi He;M. R. Gerrero;M. Mok

  • The role of VlsE antigenic variation in the Lyme disease spirochete: persistence through a mechanism that differs from other pathogens

    Troy Bankhead;George Chaconas

  • End labeling of enzymatically decapped mRNA

    Argiris Efstratiadis;John N. Vournakis;Helen Donis-Keller;George Chaconas

  • Analysis of an Ordered, Comprehensive STM Mutant Library in Infectious Borrelia burgdorferi: Insights into the Genes Required for Mouse Infectivity

    Tao Lin;Lihui Gao;Chuhua Zhang;Evelyn Odeh

  • Molecular mechanisms involved in vascular interactions of the Lyme disease pathogen in a living host.

    M. Ursula Norman;Tara J. Moriarty;Ashley R. Dresser;Brandie Millen

  • Structure, Function, and Evolution of Linear Replicons in Borrelia

    George Chaconas;Kerri Kobryn

  • Vascular binding of a pathogen under shear force through mechanistically distinct sequential interactions with host macromolecules

    Tara J. Moriarty;Meiqing Shi;Yi Pin Lin;Rhodaba Ebady

  • In vitro and in vivo manipulations of bacteriophage Mu DNA: Cloning of Mu ends and construction of mini-Mu's carrying selectable markers

    George Chaconas;Frans J. de Bruijn;Malcolm J. Casadaban;James R. Lupski

  • Investigation of the genes involved in antigenic switching at the vlsE locus in Borrelia burgdorferi: an essential role for the RuvAB branch migrase.

    Ashley R. Dresser;Pierre-Olivier Hardy;George Chaconas

  • Primary structure of phage mu transposase: homology to mu repressor

    Rasika M. Harshey;Elizabeth D. Getzoff;Donald L. Baldwin;Janet L. Miller

  • Hairpin telomeres and genome plasticity in Borrelia: all mixed up in the end.

    George Chaconas

  • Site-specific DNA binding and bending by the Borrelia burgdorferi Hbb protein

    Kerri Kobryn;Darius Z. Naigamwalla;George Chaconas

  • Mapping of essential replication functions of the linear plasmid lp17 of B. burgdorferi by targeted deletion walking

    Cécile Beaurepaire;Cécile Beaurepaire;George Chaconas

  • Conservation of Plasmid Maintenance Functions between Linear and Circular Plasmids in Borrelia burgdorferi

    Philip E. Stewart;George Chaconas;Patricia Rosa

  • Catalytic Residues of the Telomere Resolvase ResT A PATTERN SIMILAR TO, BUT DISTINCT FROM, TYROSINE RECOMBINASES AND TYPE IB TOPOISOMERASES

    Jan Deneke;Alex B. Burgin;Sandra L. Wilson;George Chaconas

  • Mixing active-site components: A recipe for the unique enzymatic activity of a telomere resolvase

    Troy Bankhead;George Chaconas

  • Invariant natural killer T cells act as an extravascular cytotoxic barrier for joint-invading Lyme Borrelia

    Woo-Yong Lee;Maria-Jesus Sanz;Connie Hoi Yee Wong;Pierre-Olivier Hardy

  • End group labelling of RNA and double stranded DNA by phosphate exchange catalyzed by bacteriophage T4 induced polynucleotide kinase.

    George Chaconas;Johan H. van de Sande;Robert B. Church

  • Intravital Imaging of Vascular Transmigration by the Lyme Spirochete: Requirement for the Integrin Binding Residues of the B. burgdorferi P66 Protein

    Devender Kumar;Laura C. Ristow;Laura C. Ristow;Meiqing Shi;Priyanka Mukherjee

Frequent Co-Authors

Paul Kubes
Paul Kubes University of Calgary
John M. Leong
John M. Leong Tufts University
Steven J. Norris
Steven J. Norris The University of Texas Health Science Center at Houston
Nancy L. Craig
Nancy L. Craig Johns Hopkins University School of Medicine
Cédric Feschotte
Cédric Feschotte Cornell University
Argiris Efstratiadis
Argiris Efstratiadis Biomedical Research Foundation of the Academy of Athens
Helen Donis-Keller
Helen Donis-Keller Washington University in St. Louis
Prescott L. Deininger
Prescott L. Deininger Tulane University
Fotis C. Kafatos
Fotis C. Kafatos Harvard University
Daniel F. Voytas
Daniel F. Voytas University of Minnesota

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