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Molecular Biology

D-Index
42
Citations
17391
World Ranking
2995
National Ranking
232

Overview

Trevor D. Littlewood is affiliated with the University of Cambridge in the United Kingdom. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Within these fields, their work focuses extensively on molecular mechanisms relevant to oncology and cardiovascular biology.

The scientist has contributed significantly to several main topics, including:

  • Pancreatic and Hepatic Oncology Research
  • Cancer-related Molecular Pathways
  • RNA Research and Splicing
  • Congenital heart defects research
  • Epigenetics and DNA Methylation
  • Phagocytosis and Immune Regulation
  • Pancreatitis Pathology and Treatment

Trevor D. Littlewood's notable recent publications include:

  • MYC Instructs and Maintains Pancreatic Adenocarcinoma Phenotype (2020, Cancer Discovery)
  • Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity (2020, Nature Communications)
  • Reversible Myc hypomorphism identifies a key Myc-dependency in early cancer evolution (2022, Nature Communications)
  • Assembly of nuclear dimers of PI3K regulatory subunits is regulated by the Cdc42-activated tyrosine kinase ACK (2022, Journal of Biological Chemistry)
  • HRas and Myc synergistically induce cell cycle progression and apoptosis of murine cardiomyocytes (2022, Frontiers in Cardiovascular Medicine)

Their research has been published in a variety of scientific journals including:

  • Nature Communications
  • Cancer Discovery
  • Journal of Biological Chemistry
  • Frontiers in Cardiovascular Medicine
  • Methods in molecular biology

Collaborations form an important aspect of their work. Frequent co-authors include Gérard I. Evan, Nicole M. Sodir, Roderik M. Kortlever, Luca Pellegrinet, and Panayiotis Anastasiou.

The scientist's focus on molecular biology techniques and cancer-related pathways reflects their interdisciplinary approach, integrating oncology, molecular biology, and medical research to explore cellular and molecular functions in health and disease.

Best Publications

  • Induction of apoptosis in fibroblasts by c-myc protein

    Gerard I. Evan;Andrew H. Wyllie;Christopher S. Gilbert;Trevor D. Littlewood

  • A Matter of Life and Cell Death

    Gerard Evan;Trevor Littlewood

  • A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins

    Trevor D. Littlewood;David C. Hancock;Paul S. Danielian;Malcolm G. Parker

  • Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis

    Murray C H Clarke;Nichola Figg;Janet J Maguire;Anthony P Davenport

  • Oncogenic activity of the c-Myc protein requires dimerization with Max

    Bruno Amati;Mary W. Brooks;Naomi Levy;Trevor D. Littlewood

  • Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max.

    Bruno Amati;Stephen Dalton;Mary W. Brooks;Trevor D. Littlewood

  • Structural basis for the interaction between FxFG nucleoporin repeats and importin-beta in nuclear trafficking.

    Richard Bayliss;Trevor Littlewood;Murray Stewart

  • Reversible activation of c-Myc in skin: induction of a complex neoplastic phenotype by a single oncogenic lesion.

    Stella Pelengaris;Trevor Littlewood;Michael Khan;George Elia

  • The c-Myc protein induces cell cycle progression and apoptosis through dimerization with Max.

    B Amati;T D Littlewood;G I Evan;H Land

  • The role of c-myc in cell growth.

    Gerard I. Evan;Trevor D. Littlewood

  • Chronic Apoptosis of Vascular Smooth Muscle Cells Accelerates Atherosclerosis and Promotes Calcification and Medial Degeneration

    Murray C.H. Clarke;Trevor D. Littlewood;Nichola Figg;Janet J. Maguire

  • Myc Cooperates with Ras by Programming Inflammation and Immune Suppression

    Roderik Marco Kortlever;Roderik Marco Kortlever;Nicole M Sodir;Nicole M Sodir;Catherine Helen Wilson;Deborah L Burkhart

  • Inducible site-directed recombination in mouse embryonic stem cells.

    Yong Zhang;Christa Riesterer;Anne-Marie Ayrall;Fred Sablitzky

  • c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release

    Philippe Juin;Anne-Odile Hueber;Trevor Littlewood;Gerard Evan

  • Glfg and Fxfg Nucleoporins Bind to Overlapping Sites on Importin-Beta

    Richard Bayliss;Trevor Littlewood;Lisa A. Strawn;Susan R. Wente

  • Apoptotic cell death in atherosclerosis.

    Trevor D. Littlewood;Martin R. Bennett

  • c-Myc functionally cooperates with Bax to induce apoptosis.

    Philippe Juin;Abigail Hunt;Trevor Littlewood;Beatrice Griffiths

  • Increased Sensitivity of Human Vascular Smooth Muscle Cells From Atherosclerotic Plaques to p53-Mediated Apoptosis

    Martin R. Bennett;Trevor D. Littlewood;Stephen M. Schwartz;Peter L. Weissberg

  • Molecular mechanism of translocation through nuclear pore complexes during nuclear protein import

    Murray Stewart;Rosanna P Baker;Richard Bayliss;Lesley Clayton

  • MYC Instructs and Maintains Pancreatic Adenocarcinoma Phenotype

    Nicole M. Sodir;Roderik M. Kortlever;Valentin J.A. Barthet;Tania Campos

Frequent Co-Authors

Gerard I. Evan
Gerard I. Evan The Francis Crick Institute
Martin R. Bennett
Martin R. Bennett University of Cambridge
Mark J. Arends
Mark J. Arends University of Edinburgh
Bruno Amati
Bruno Amati European Institute of Oncology
Julian L. Griffin
Julian L. Griffin University of Aberdeen
Ronald M. Evans
Ronald M. Evans Salk Institute for Biological Studies
Kari Alitalo
Kari Alitalo University of Helsinki
Anthony P. Davenport
Anthony P. Davenport University of Cambridge
Michael Downes
Michael Downes Salk Institute for Biological Studies
Gillian Murphy
Gillian Murphy University of Cambridge

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