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Medicine

D-Index
97
Citations
38652
World Ranking
9202
National Ranking
4745

Research.com Recognitions

  • 2017 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Frederick F. Lang is affiliated with The University of Texas MD Anderson Cancer Center in the United States. Their research primarily focuses on the intersection of medicine, biochemistry, genetics, and molecular biology, with a particular emphasis on genetics, molecular biology, oncology, immunology, and pulmonary and respiratory medicine.

The research topics covered by Frederick F. Lang include:

  • Glioma Diagnosis and Treatment
  • Virus-based gene therapy research
  • CAR-T cell therapy research
  • Cancer Research and Treatments
  • Brain Metastases and Treatment
  • Immune cells in cancer
  • Neuroinflammation and Neurodegeneration Mechanisms

Several frequent coauthors have collaborated extensively with Frederick F. Lang, including Joy Gumin, Juàn Fueyo, Candelaria Gomez-Manzano, Brittany C. Parker Kerrigan, and Sanjay K. Singh.

The scientist has published research in numerous venues, with the most notable publication outlets being:

  • Neuro-Oncology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Neuro-Oncology Advances
  • Nature Communications

Examples of recent papers authored or coauthored by Frederick F. Lang include:

  • Single-cell analysis of human glioma and immune cells identifies S100A4 as an immunotherapy target (2022, Nature Communications)
  • Oncolytic DNX-2401 Virus for Pediatric Diffuse Intrinsic Pontine Glioma (2022, New England Journal of Medicine)
  • Targeting the αv integrin/TGF-β axis improves natural killer cell function against glioblastoma stem cells (2021, Journal of Clinical Investigation)
  • Oncolytic DNX-2401 virotherapy plus pembrolizumab in recurrent glioblastoma: a phase 1/2 trial (2023, Nature Medicine)
  • Circadian Regulator CLOCK Recruits Immune-Suppressive Microglia into the GBM Tumor Microenvironment (2020, Cancer Discovery)

Frederick F. Lang was awarded the Fellow of the American Association for the Advancement of Science (AAAS) in 2017.

Best Publications

  • A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival

    Michel Lacroix;Dima Abi-Said;Daryl R. Fourney;Ziya L. Gokaslan

  • Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial.

    Eric L Chang;Jeffrey S Wefel;Kenneth R Hess;Pamela K Allen

  • Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma

    Adrian Ally;Miruna Balasundaram;Rebecca Carlsen;Eric Chuah

  • Human Bone Marrow–Derived Mesenchymal Stem Cells in the Treatment of Gliomas

    Akira Nakamizo;Frank Marini;Toshiyuki Amano;Asadullah Khan

  • Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma

    Krishna P.L. Bhat;Veerakumar Balasubramaniyan;Brian Vaillant;Ravesanker Ezhilarasan

  • Post-operative stereotactic radiosurgery versus observation for completely resected brain metastases: a single-centre, randomised, controlled, phase 3 trial

    Anita Mahajan;Salmaan Ahmed;Mary Frances McAleer;Jeffrey S Weinberg

  • Phase I Study of DNX-2401 (Delta-24-RGD) Oncolytic Adenovirus: Replication and Immunotherapeutic Effects in Recurrent Malignant Glioma.

    Frederick F Lang;Charles Conrad;Candelaria Gomez-Manzano;W K Alfred Yung

  • Limitations of stereotactic biopsy in the initial management of gliomas

    Robert J. Jackson;Gregory N. Fuller;Dima Abi-Said;Frederick F. Lang

  • Transthoracic vertebrectomy for metastatic spinal tumors

    Ziya L. Gokaslan;Julie E. York;Garrett L. Walsh;Ian E. McCutcheon

  • Phase I Trial of Adenovirus-Mediated p53 Gene Therapy for Recurrent Glioma: Biological and Clinical Results

    Frederick F. Lang;Janet M. Bruner;Gregory N. Fuller;Kenneth Aldape

  • IDH1 mutant malignant astrocytomas are more amenable to surgical resection and have a survival benefit associated with maximal surgical resection

    Jason Beiko;Dima Suki;Kenneth R Hess;Benjamin D. Fox;Benjamin D. Fox

  • FoxM1B Is Overexpressed in Human Glioblastomas and Critically Regulates the Tumorigenicity of Glioma Cells

    Mingguang Liu;Bingbing Dai;Shin Hyuk Kang;Kechen Ban

  • Cyclooxygenase-2 expression in human gliomas: prognostic significance and molecular correlations.

    Tadahisa Shono;Philip J. Tofilon;Janet M. Bruner;Olubunmi Owolabi

  • Pathways leading to glioblastoma multiforme : a molecular analysis of genetic alterations in 65 astrocytic tumors

    Frederick F. Lang;Douglas C. Miller;Maxim Koslow;Elizabeth W. Newcomb

  • The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant glioma

    Krishna P.L. Bhat;Krishna P.L. Bhat;Katrina L. Salazar;Katrina L. Salazar;Veerakumar Balasubramaniyan;Veerakumar Balasubramaniyan;Veerakumar Balasubramaniyan;Khalida Wani

  • Preclinical Characterization of the Antiglioma Activity of a Tropism-Enhanced Adenovirus Targeted to the Retinoblastoma Pathway

    Juan Fueyo;Ramon Alemany;Candelaria Gomez-Manzano;Gregory N. Fuller

  • Extent of Resection of Glioblastoma Revisited: Personalized Survival Modeling Facilitates More Accurate Survival Prediction and Supports a Maximum-Safe-Resection Approach to Surgery

    Nicholas F. Marko;Robert J. Weil;Jason L. Schroeder;Frederick F. Lang

  • Direct intracerebral delivery of cintredekin besudotox (IL13-PE38QQR) in recurrent malignant glioma: a report by the Cintredekin Besudotox Intraparenchymal Study Group.

    Sandeep Kunwar;Michael D. Prados;Susan M. Chang;Mitchel S. Berger

  • An implantable guide-screw system for brain tumor studies in small animals.

    Sumeer Lal;Michel Lacroix;Philip Tofilon;Gregory N Fuller

  • Examination of the Therapeutic Potential of Delta-24-RGD in Brain Tumor Stem Cells: Role of Autophagic Cell Death

    Hong Jiang;Candelaria Gomez-Manzano;Hiroshi Aoki;Hiroshi Aoki;Marta M. Alonso

Frequent Co-Authors

Raymond Sawaya
Raymond Sawaya The University of Texas MD Anderson Cancer Center
Gregory N. Fuller
Gregory N. Fuller The University of Texas MD Anderson Cancer Center
W. K. Alfred Yung
W. K. Alfred Yung The University of Texas MD Anderson Cancer Center
Hong Jiang
Hong Jiang Central South University
Waldemar Priebe
Waldemar Priebe The University of Texas MD Anderson Cancer Center
Kenneth R. Hess
Kenneth R. Hess The University of Texas MD Anderson Cancer Center
Roel G.W. Verhaak
Roel G.W. Verhaak The Jackson Laboratory
Michael Andreeff
Michael Andreeff The University of Texas MD Anderson Cancer Center
Mark R. Gilbert
Mark R. Gilbert National Institutes of Health
wei zhang
wei zhang Wake Forest University

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