World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
81
Citations
31682
World Ranking
3808
National Ranking
1885

Research.com Recognitions

  • 1981 - Fellow of Alfred P. Sloan Foundation

Overview

Lee L. Rubin is affiliated with Harvard University in the United States and focuses research within the broad fields of Biochemistry, Genetics and Molecular Biology as well as Medicine. Their work spans several subfields including Molecular Biology, Neurology, Physiology, Cellular and Molecular Neuroscience, and Genetics.

The key topics investigated in their research encompass Muscle Physiology and Disorders, Parkinson's Disease Mechanisms and Treatments, Neuroinflammation and Neurodegeneration Mechanisms, Pluripotent Stem Cells Research, CRISPR and Genetic Engineering, Alzheimer's Disease research and treatments, and Single-cell and spatial transcriptomics.

Lee L. Rubin has published extensively in several venues. Frequent publication venues include bioRxiv (Cold Spring Harbor Laboratory) with 9 publications, Nature Communications with 4 publications, Cell Reports with 3, Nature Aging with 2, and Stem Cell Reports with 2 publications.

Frequent collaborators include Kristina M. Holton, Richard M. Giadone, Lance S. Davidow, Amy J. Wagers, and Sean M. Buchanan, reflecting active partnerships in multiple studies.

Recent papers exemplify the diversity and reach of their research:

  • Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption, 2021, Nature Communications
  • Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration, 2023, Neuron
  • FOS licenses early events in stem cell activation driving skeletal muscle regeneration, 2021, Cell Reports
  • A pesticide and iPSC dopaminergic neuron screen identifies and classifies Parkinson-relevant pesticides, 2023, Nature Communications
  • Heterochronic parabiosis reprograms the mouse brain transcriptome by shifting aging signatures in multiple cell types, 2023, Nature Aging

Lee L. Rubin was awarded the Fellow of Alfred P. Sloan Foundation in 1981.

Best Publications

  • THE CELL BIOLOGY OF THE BLOOD-BRAIN BARRIER

    L L Rubin;J M Staddon

  • A paracrine requirement for hedgehog signalling in cancer

    Robert L. Yauch;Stephen E. Gould;Suzie J. Scales;Tracy Tang

  • Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors.

    Lida Katsimpardi;Nadia K. Litterman;Pamela A. Schein;Christine M. Miller;Christine M. Miller

  • A c-jun dominant negative mutant protects sympathetic neurons against programmed cell death

    Jonathan Ham;Carol Babij;Jonathan Whitfield;Curt M Pfarr

  • Targeting the Hedgehog pathway in cancer

    Lee L. Rubin;Frederic J. de Sauvage

  • A Small Molecule Inhibitor of Tgf-β Signaling Replaces Sox2 in Reprogramming by Inducing Nanog

    Justin K. Ichida;Joel Blanchard;Kelvin Lam;Esther Y. Son

  • A cell culture model of the blood-brain barrier.

    L L Rubin;D E Hall;S Porter;K Barbu

  • Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches.

    Robert Machold;Shigemi Hayashi;Michael Rutlin;Mandar D. Muzumdar

  • Occludin as a possible determinant of tight junction permeability in endothelial cells

    Tetsuaki Hirase;James M. Staddon;Mitinori Saitou;Yuhko Ando-Akatsuka

  • Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation

    Jason Rihel;David A. Prober;Anthony Arvanites;Kelvin Lam

  • A TALEN Genome-Editing System for Generating Human Stem Cell-Based Disease Models

    Qiurong Ding;Youn-Kyoung Lee;Esperance Anne Kreek Schaefer;Derek Tilghman Peters

  • Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.

    Justyna T. Romer;Hiromichi Kimura;Susan Magdaleno;Ken Sasai

  • Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

    Maria Frank-Kamenetsky;Xiaoyan M Zhang;Steve Bottega;Oivin Guicherit

  • SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy

    Nikolai A. Naryshkin;Marla Weetall;Amal Dakka;Jana Narasimhan

  • A small molecule that directs differentiation of human ESCs into the pancreatic lineage

    Shuibing Chen;Shuibing Chen;Malgorzata Borowiak;Julia L Fox;René Maehr;René Maehr

  • In Silico Labeling: Predicting Fluorescent Labels in Unlabeled Images

    Eric M. Christiansen;Samuel J. Yang;D. Michael Ando;Ashkan Javaherian

  • Single-cell transcriptomic profiling of the aging mouse brain.

    Methodios Ximerakis;Scott L Lipnick;Brendan T Innes;Sean K Simmons

  • A comparison of non-integrating reprogramming methods.

    Thorsten M. Schlaeger;Laurence Marie Daheron;Thomas R Brickler;Samuel Entwisle

  • Phosphorylation of c-Jun Is Necessary for Apoptosis Induced by Survival Signal Withdrawal in Cerebellar Granule Neurons

    Andrea Watson;Andreas Eilers;Dominique Lallemand;John Kyriakis

  • GDC-0449-a potent inhibitor of the hedgehog pathway.

    Kirk D. Robarge;Shirley A. Brunton;Georgette M. Castanedo;Yong Cui

Frequent Co-Authors

Amy J. Wagers
Amy J. Wagers Harvard University
Kevin Eggan
Kevin Eggan Harvard University
Douglas A. Melton
Douglas A. Melton Harvard University
Chad A. Cowan
Chad A. Cowan Beth Israel Deaconess Medical Center
Alexander Meissner
Alexander Meissner Max Planck Institute for Molecular Genetics
Andrew P. McMahon
Andrew P. McMahon University of Southern California
Christoph Bock
Christoph Bock Austrian Academy of Sciences
Richard T. Lee
Richard T. Lee Harvard University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring a degree in Biology or Biochemistry opens doors to a wide variety of related careers and study options. For students interested in the intersection between biology, human health, and movement, consider reviewing the best online exercise science degree programs. These programs offer flexible pathways to roles such as exercise physiologist or health coach.

Fields like kinesiology build on foundational biology knowledge as well. Earning online kinesiology degrees can prepare you for dynamic careers in fitness, rehabilitation, or sports medicine, all while studying at your own pace.

For those interested in specialized healthcare roles, consider the shortest pmhnp certificate program to fast-track your pathway to becoming a Psychiatric Mental Health Nurse Practitioner. Alternatively, the cheapest post master's fnp program is ideal for professionals seeking affordable options to become a Family Nurse Practitioner.

These diverse online degrees and certificates can help you find the career path that best aligns with your interests in biology, biochemistry, and health sciences.

Best Scientists Citing Lee L. Rubin

Trending Scientists

Recently Published Articles