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Molecular Biology

D-Index
44
Citations
13949
World Ranking
2893
National Ranking
1378

Overview

Thorsten M. Schlaeger is affiliated with Boston Children's Hospital in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine with a focused contribution to several subfields including Molecular Biology, Immunology, Hematology, Oncology, and Genetics.

Their work addresses multiple key topics such as CRISPR and Genetic Engineering, CAR-T cell therapy research, Pluripotent Stem Cells Research, Neonatal Respiratory Health Research, Epigenetics and DNA Methylation, Genomics and Chromatin Dynamics, and RNA Research and Splicing.

Schlaeger's publication record includes a number of recent papers, notable examples being:

  • Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells, 2020, published in Cell Stem Cell
  • EZH1 repression generates mature iPSC-derived CAR T cells with enhanced antitumor activity, 2022, published in Cell Stem Cell
  • A Platelet Function Modulator of Thrombin Activation Is Causally Linked to Cardiovascular Disease and Affects PAR4 Receptor Signaling, 2020, published in The American Journal of Human Genetics
  • Mitochondrial and Redox Modifications in Huntington Disease Induced Pluripotent Stem Cells Rescued by CRISPR/Cas9 CAGs Targeting, 2020, published in Frontiers in Cell and Developmental Biology
  • Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells, 2020, published in bioRxiv (Cold Spring Harbor Laboratory)

The scientist has frequently collaborated with peers such as George Q. Daley, Trista E. North, Caroline Kubaczka, Mohamad Najia, and Edroaldo Lummertz da Rocha. These collaborations have contributed to advancing research in their fields of study.

Thorsten M. Schlaeger has published extensively in several venues including bioRxiv (Cold Spring Harbor Laboratory), Experimental Hematology, Blood, Cell Stem Cell, and the Journal of Cystic Fibrosis, reflecting a diverse range of research interests and interdisciplinary engagement.

Best Publications

  • Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA

    Luigi Warren;Philip D. Manos;Philip D. Manos;Tim Ahfeldt;Tim Ahfeldt;Yuin-Han Loh

  • Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts.

    Akiko Doi;In Hyun Park;Bo Wen;Peter Murakami

  • Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells

    Sabine Loewer;Moran N Cabili;Moran N Cabili;Mitchell Guttman;Yuin-Han Loh

  • Uniform vascular-endothelial-cell-specific gene expression in both embryonic and adult transgenic mice.

    Thorsten M. Schlaeger;Sona Bartunkova;Joel A. Lawitts;Gunnar Teichmann

  • Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells

    Elayne M. Chan;Sutheera Ratanasirintrawoot;Sutheera Ratanasirintrawoot;In Hyun Park;Philip D. Manos;Philip D. Manos

  • A comparison of non-integrating reprogramming methods.

    Thorsten M. Schlaeger;Laurence Marie Daheron;Thomas R Brickler;Samuel Entwisle

  • Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/ tal-1 gene

    Hanna K. A. Mikkola;Jenny Klintman;Haidi Yang;Hanno Hock

  • Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo.

    Hanna K. A. Mikkola;Yuko Fujiwara;Thorsten M. Schlaeger;David Traver

  • Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells

    Fabien G Lafaille;Itai M. Pessach;Itai M. Pessach;Shen-Ying Zhang;Shen-Ying Zhang;Michael J. Ciancanelli

  • Prostaglandin E2 Enhances Human Cord Blood Stem Cell Xenotransplants and Shows Long-Term Safety in Preclinical Nonhuman Primate Transplant Models

    Wolfram Goessling;Robyn S. Allen;Xiao Guan;Ping Jin

  • Vascular endothelial cell lineage-specific promoter in transgenic mice

    T. M. Schlaeger;Ying Qin;Y. Fujiwara;J. Magram

  • Role of SCL/Tal-1, GATA, and Ets transcription factor binding sites for the regulation of Flk-1 expression during murine vascular development

    Andreas Kappel;Andreas Kappel;Andreas Kappel;Thorsten M. Schlaeger;Thorsten M. Schlaeger;Thorsten M. Schlaeger;Ingo Flamme;Ingo Flamme;Ingo Flamme;Stuart H. Orkin;Stuart H. Orkin;Stuart H. Orkin

  • Endothelium-specific replacement of the connexin43 coding region by a lacZ reporter gene

    M Theis;C de Wit;T M Schlaeger;D Eckardt

  • Teratoma Formation Assays with Human Embryonic Stem Cells: A Rationale for One Type of Human-Animal Chimera

    M. William Lensch;Thorsten M. Schlaeger;Thorsten M. Schlaeger;Leonard I. Zon;George Q. Daley

  • Overcoming Reprogramming Resistance of Fanconi Anemia Cells

    Lars U. W. Müller;Michael D. Milsom;Chad E. Harris;Rutesh Vyas

  • Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells

    Finn J. Hawkins;Shingo Suzuki;Mary Lou Beermann;Cristina Barillà

  • Using CRISPR-Cas9 to Generate Gene-Corrected Autologous iPSCs for the Treatment of Inherited Retinal Degeneration

    Erin R. Burnight;Manav Gupta;Luke A. Wiley;Kristin R. Anfinson

  • Improved Electrospray Ionization Efficiency Compensates for Diminished Chromatographic Resolution and Enables Proteomics Analysis of Tyrosine Signaling in Embryonic Stem Cells

    Scott B. Ficarro;Yi Zhang;Yu Lu;Ahmadali R. Moghimi

  • Tie2Cre-mediated gene ablation defines the stem-cell leukemia gene (SCL/tal1)-dependent window during hematopoietic stem-cell development.

    Thorsten M. Schlaeger;Hanna K. A. Mikkola;Hanna K. A. Mikkola;Christos Gekas;Christos Gekas;Hildur B. Helgadottir;Hildur B. Helgadottir

  • Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells

    Finn J. Hawkins;Finn J. Hawkins;Shingo Suzuki;Mary Lou Beermann;Cristina Barillà

Frequent Co-Authors

George Q. Daley
George Q. Daley Boston Children's Hospital
Leonard I. Zon
Leonard I. Zon Harvard University
Trista E. North
Trista E. North Boston Children's Hospital
Stuart H. Orkin
Stuart H. Orkin Harvard University
Benjamin L. Ebert
Benjamin L. Ebert Harvard University
In-Hyun Park
In-Hyun Park Yale University
Akiko Shimamura
Akiko Shimamura Harvard University
Hanna K.A. Mikkola
Hanna K.A. Mikkola University of California, Los Angeles
Wolfram Goessling
Wolfram Goessling Brigham and Women's Hospital
Axel Schambach
Axel Schambach Hannover Medical School

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